{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:25:52Z","timestamp":1787930752479,"version":"build-2784847793"},"reference-count":16,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_med-2026-1472_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the incidence and severity of contrast-induced acute kidney injury(PC-AKI) cause by isotonic and low-osmolar iodinated contrast media of patients with renal insufficiency undergoing intravenous administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1472_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected the patients diagnosed with confirmed renal insufficiency after January 1, 2022, and they were scheduled for enhanced CT examination. Then these patients were randomly divided into the isotonic contrast agent Iodixanol group, the hypertonic contrast agent Ioversol group, Iohexol group, Iomeprol group and Iopromide group. After hospitalization, these patients were routinely checked for renal function and calculated glomerular filtration rate. Finally, these patients underwent renal function examination again within 48\u201372\u202fh and the glomerular filtration rates were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1472_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were statistical differences in age and cystatin C among the groups. However, it was no significant difference in serum creatinine, glomerular filtration rate before CT enhancement and serum creatinine, glomerular filtration rate, uric acid and urea after CT enhancement in each group. For patients with renal insufficiency, the incidence of PC-AKI caused by isotonic contrast agents and multiple hypertonic contrast agents was 0\u20134.3\u202f%, and there was no statistical difference in the incidence of PC-AKI among the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1472_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Isotonic contrast agent and hypertonic contrast agent all have good renal safety in people with renal insufficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2026-1472","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:57:03Z","timestamp":1787929023000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparative study of acute kidney injury caused by isotonic and low-osmolar iodinated contrast media in patients with renal insufficiency"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1636-3853","authenticated-orcid":false,"given":"Ya","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology, Department of Oncology and Department of Gastroenterology , Chengdu Third People\u2019s Hospital , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1740-4354","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Oncology and Department of Gastroenterology , Chengdu Third People\u2019s Hospital , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0652-8346","authenticated-orcid":false,"given":"Mengqi","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Oncology and Department of Gastroenterology , Chengdu Third People\u2019s Hospital , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6083-2232","authenticated-orcid":false,"given":"Hua","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Oncology and Department of Gastroenterology , Chengdu Third People\u2019s Hospital , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0079-6806","authenticated-orcid":false,"given":"Ling","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Oncology and Department of Gastroenterology , Chengdu Third People\u2019s Hospital , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2125-0901","authenticated-orcid":false,"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Oncology and Department of Gastroenterology , Chengdu Third People\u2019s Hospital , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0669-1281","authenticated-orcid":false,"given":"Han","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Oncology and Department of Gastroenterology , Chengdu Third People\u2019s Hospital , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2050-6270","authenticated-orcid":false,"given":"Zhengkai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Oncology and Department of Gastroenterology , Chengdu Third People\u2019s Hospital , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"2026082814565875539_j_med-2026-1472_ref_001","doi-asserted-by":"crossref","unstructured":"Mccullough, PA, Choi, JP, Feghali, GA, Schussler, JM, Stoler, RM, Vallabahn, RC, et al.. J\u00a0Am Coll Cardiol 2008;51:1419\u201328. https:\/\/doi.org\/10.1016\/j.jacc.2016.05.099.","DOI":"10.1016\/j.jacc.2016.05.099"},{"key":"2026082814565875539_j_med-2026-1472_ref_002","doi-asserted-by":"crossref","unstructured":"Davenport, MS, Perazella, MA, Yee, J, Dillman, JR, Fine, D, McDonald, RJ, et al.. Use of intravenous iodinated contrast media in patients with kidney disease: consensus statements from the American college of radiology and the national kidney foundation. Radiology 2020;294:660\u20138. https:\/\/doi.org\/10.1148\/radiol.2019192094.","DOI":"10.1148\/radiol.2019192094"},{"key":"2026082814565875539_j_med-2026-1472_ref_003","doi-asserted-by":"crossref","unstructured":"Global burden of chronic respiratory diseases and risk factors. 1990\u20132019: an update from the global burden of disease study 2019. EClinicalMedicine 2023;59:101936. https:\/\/doi.org\/10.1016\/j.eclinm.2023.101936.","DOI":"10.1016\/j.eclinm.2023.101936"},{"key":"2026082814565875539_j_med-2026-1472_ref_004","doi-asserted-by":"crossref","unstructured":"Vandermolen, AJ, Reimer, P, Dekkers, IA, Bongartz, G, Bellin, MF, Bertolotto, M, et al.. Post-contrast acute kidney injury. Part 2 : risk stratification, role of hydration and other prophylactic measures, patients taking metformin and chronic dialysis patients: recommendations for updated ESUR contrast medium safety committee guidelines. Eur Radiol 2018;28:2856\u201369. https:\/\/doi.org\/10.1007\/s00330-017-5247-4.","DOI":"10.1007\/s00330-017-5247-4"},{"key":"2026082814565875539_j_med-2026-1472_ref_005","doi-asserted-by":"crossref","unstructured":"Nash, K, Hafeez, A, Hou, S. Hospital-acquired renal insufciency. Am J Kidney Dis 2002;39:930\u20136. https:\/\/doi.org\/10.1053\/ajkd.2002.32766.","DOI":"10.1053\/ajkd.2002.32766"},{"key":"2026082814565875539_j_med-2026-1472_ref_006","doi-asserted-by":"crossref","unstructured":"Raupkonsavagee, WM, Wang, Y, Wang, WW, Feliers, D, Ruan, H, Reeves, WB, et al.. Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia\/reperfusion-induced acute kidney injury. Kidney Int 2018;93:365\u201374. https:\/\/doi.org\/10.1016\/j.kint.2017.08.014.","DOI":"10.1016\/j.kint.2017.08.014"},{"key":"2026082814565875539_j_med-2026-1472_ref_007","doi-asserted-by":"crossref","unstructured":"Chen, L, Huang, Z, Li, W, He, Y, Liang, J, Lu, J, et al.. Malnutrition and the risk for contrast-induced acute kidney injury in patients with coronary artery disease. Int Urol Nephrol 2022;54:429\u201335. https:\/\/doi.org\/10.1007\/s11255-021-02915-6.","DOI":"10.1007\/s11255-021-02915-6"},{"key":"2026082814565875539_j_med-2026-1472_ref_008","doi-asserted-by":"crossref","unstructured":"Giles, T, Weaver, N, Varghese, A, Way, TL, Abel, C, Choi, P, et al.. Acute kidney injury development in polytrauma and the safety of early repeated contrast studies: a retrospective cohort study. J\u00a0Trauma Acute Care Surg 2022;93:872\u201381. https:\/\/doi.org\/10.1097\/ta.0000000000003735.","DOI":"10.1097\/TA.0000000000003735"},{"key":"2026082814565875539_j_med-2026-1472_ref_009","doi-asserted-by":"crossref","unstructured":"Carande, EJ, Brown, K, Jackson, D, Maskell, N, Kouzaris, L, Greene, G, et al.. Acute kidney injury following percutaneous coronary intervention for acute coronary syndrome: incidence, aetiology, risk factors and outcomes. Angiology 2022;73:139\u201345. https:\/\/doi.org\/10.1177\/00033197211040375.","DOI":"10.1177\/00033197211040375"},{"key":"2026082814565875539_j_med-2026-1472_ref_010","doi-asserted-by":"crossref","unstructured":"Cashion, W, Weisbord, SD. Radiographic contrast media and the kidney. Clin J Am Soc Nephrol 2022;17:1234\u201342. https:\/\/doi.org\/10.2215\/cjn.16311221.","DOI":"10.2215\/CJN.16311221"},{"key":"2026082814565875539_j_med-2026-1472_ref_011","doi-asserted-by":"crossref","unstructured":"Moos, SI, Van Vemde, DN, Stoker, J, Bipat, S. Contrast induced nephropathy in patients undergoing intravenous (IV) contrast enhanced computed tomography (CECT) and the relationship with risk factors: a meta-analysis. Eur J Radiol 2013;82:e387\u201399. https:\/\/doi.org\/10.1016\/j.ejrad.2013.04.029.","DOI":"10.1016\/j.ejrad.2013.04.029"},{"key":"2026082814565875539_j_med-2026-1472_ref_012","doi-asserted-by":"crossref","unstructured":"Kooiman, J, Pasha, SM, Zondag, W, Sijpkens, YW, Vandermolen, AJ, Huisman, MV, et al.. Meta-analysis: serum creatinine changes following contrast enhanced CT imaging. Eur J Radiol 2012;81:2554\u201361. https:\/\/doi.org\/10.1016\/j.ejrad.2011.11.020.","DOI":"10.1016\/j.ejrad.2011.11.020"},{"key":"2026082814565875539_j_med-2026-1472_ref_013","doi-asserted-by":"crossref","unstructured":"Mcdonald, JS, Mcdonald, RJ, Comin, J, Williamson, EE, Katzberg, RW, Murad, MH, et al.. Frequency of acute kidney injury following intravenous contrast medium administration: a systematic review and meta-analysis. Radiology 2013;267:119\u201328. https:\/\/doi.org\/10.1148\/radiol.12121460.","DOI":"10.1148\/radiol.12121460"},{"key":"2026082814565875539_j_med-2026-1472_ref_014","unstructured":"Eng, J, Subramaniam, RM, Wilsonn, RF, Turban, S, Choi, MJ, Zhang, A, et al.. AHRQ comparative effectiveness reviews [M]. Contrast-induced nephropathy: comparative effects of different contrast media. Rockville (MD): Agency for Healthcare Research and Quality (US); 2015."},{"key":"2026082814565875539_j_med-2026-1472_ref_015","doi-asserted-by":"crossref","unstructured":"Heinrich, MC, Haberle, L, M\u00fcller, V, Bautz, W, Uder, M. Nephrotoxicity of iso-osmolar iodixanol compared with nonionic low-osmolar contrast media: meta-analysis of randomized controlled trials. Radiology 2009;250:68\u201386. https:\/\/doi.org\/10.1148\/radiol.2501080833.","DOI":"10.1148\/radiol.2501080833"},{"key":"2026082814565875539_j_med-2026-1472_ref_016","doi-asserted-by":"crossref","unstructured":"Tran, PNT, Kusirisin, P, Kaewdoungtien, P, Phannajit, J, Srisawat, N. Higher blood pressure versus normotension targets to prevent acute kidney injury: a systematic review and meta-regression of randomized controlled trials. Crit Care 2022;26:364. https:\/\/doi.org\/10.1186\/s13054-022-04236-1.","DOI":"10.1186\/s13054-022-04236-1"}],"container-title":["Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/med-2026-1472\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/med-2026-1472\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:57:07Z","timestamp":1787929027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/med-2026-1472\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,8,31]]},"published-print":{"date-parts":[[2026,1,23]]}},"alternative-id":["10.1515\/med-2026-1472"],"URL":"https:\/\/doi.org\/10.1515\/med-2026-1472","relation":{},"ISSN":["2391-5463"],"issn-type":[{"value":"2391-5463","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"article-number":"20261472"}}