{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:15:46Z","timestamp":1783660546184,"version":"3.55.0"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_med-2026-1489_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Chronic inflammation, oxidative stress, and metabolic dysfunction are central drivers of biological aging. Polyphenolics from\n                      <jats:italic>Sorghum bicolor<\/jats:italic>\n                      , particularly 3-deoxyanthocyanidins, have the potential to modulate biological aging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1489_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We investigated\n                      <jats:italic>Sorghum bicolor<\/jats:italic>\n                      through integrative evidence synthesis. Then, utilised an integrated computational framework comprising network pharmacology, and molecular docking to identify key molecular targets of\n                      <jats:italic>Sorghum bicolor<\/jats:italic>\n                      polyphenols. The findings were validated by aligning findings with the data from\n                      <jats:italic>Sorghum bicolor<\/jats:italic>\n                      on high-fat diet\/streptozotocin (HFD-STZ) induced type 2 diabetes with chronic stress using a polyphenol-rich\n                      <jats:italic>Sorghum bicolor<\/jats:italic>\n                      extract as treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1489_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We observed a dose-dependent efficacy pattern that was strongly associated with anti-oxidant and anti-inflammation in\n                      <jats:italic>Sorghum bicolor<\/jats:italic>\n                      (Jobelyn\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ). Computational analyses identified NF-\u03baB, Keap1\u2013Nrf2, and PPAR-\u03b3 as predicted high-confidence targets. The molecular docking suggests plausible interactions with the targets with the 3-deoxyanthocyanidins (Apigeninidin and Luteolinidin). The\n                      <jats:italic>in\u00a0vivo<\/jats:italic>\n                      validation demonstrated the activation of Nrf2-mediated antioxidant pathway. These biological effects aligned with computational predictions and were achieved using the whole extract.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1489_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The findings from this study supports the mechanistic plausibility of\n                      <jats:italic>Sorghum bicolor<\/jats:italic>\n                      polyphenols as modulators of inflammaging and metabolic dysfunction. This integrative framework provides the background for further translational and clinical investigation in aging-associated chronic diseases and treatments.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2026-1489","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:56:46Z","timestamp":1783659406000},"source":"Crossref","is-referenced-by-count":0,"title":["Computational and experimental evidence supports the modulation of inflammaging-related pathways by Sorghum bicolor 3-deoxyanthocyanidins"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2010-1709","authenticated-orcid":false,"given":"Oluwafemi G.","family":"Oluwole","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics , Olabisi Onabanjo University , Sagamu , Nigeria"},{"name":"Institute of Infectious Diseases and Molecular Medicine , University of Cape Town , Cape Town , South Africa"},{"name":"Department of Non-Communicable Diseases , Kenyan Institute of Primate Research , Nairobi , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9174-8169","authenticated-orcid":false,"given":"Okubena","family":"Olajuwon","sequence":"additional","affiliation":[{"name":"Health Forever Nutraceuticals , Lagos , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"2026071004564236520_j_med-2026-1489_ref_001","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Ot\u00edn, C, Blasco, MA, Partridge, L, Serrano, M, Kroemer, G. 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