{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:54:54Z","timestamp":1790686494168,"version":"4.1.0"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_med-2026-1501_abs_002\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Traumatic stress triggers systemic inflammation and organ injury via HMGB1 and endoplasmic reticulum stress (ERS), but whether H\n                      <jats:sub>2<\/jats:sub>\n                      S modulates this pathway remains unclear. This study aimed to investigate the effects of exogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S (NaHS, an H\n                      <jats:sub>2<\/jats:sub>\n                      S donor) on traumatic stress-induced HMGB1 and ERS changes in rat liver and lungs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1501_abs_003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male SD rats underwent bilateral hindlimb crush. Sixty rats were assigned to sham, crush, NaHS pretreatment (14, 28, 56\u202f\u03bcmol\/kg), delayed NaHS (120\u202f\u03bcmol\/kg), and NaHS-only groups (n=6). Serum ALT\/AST, histopathology, HMGB1 (ELISA\/IHC), and ERS markers (GRP78, caspase-12, CHOP, IRE1\u03b1) were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1501_abs_004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Crush increased ALT\/AST, liver\/lung injury, plasma HMGB1, cytoplasmic HMGB1 translocation, and ERS activation. NaHS at 28\u202f\u03bcmol\/kg offered strongest protection, reducing all parameters. The 14\u202f\u03bcmol\/kg dose had limited effect; 56\u202f\u03bcmol\/kg showed reduced efficacy and mild toxicity. Delayed 120\u202f\u03bcmol\/kg also attenuated injury and HMGB1\u2013ERS activation, though less effectively than 28\u202f\u03bcmol\/kg pretreatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1501_abs_005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Exogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S attenuates traumatic stress-induced acute liver\/lung injury, likely by inhibiting the HMGB1-mediated ERS pathway. Optimal protection occurs at\u00a028\u202f\u03bcmol\/kg, while higher doses exhibit biphasic effects. These findings may inform forensic and critical care strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2026-1501","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:59:01Z","timestamp":1790683141000},"source":"Crossref","is-referenced-by-count":0,"title":["Exogenous H\n                    <sub>2<\/sub>\n                    S suppresses traumatic stress-induced changes of HMGB1 and ERS in rat liver and lungs"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0899-9486","authenticated-orcid":false,"given":"Qingjie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Police , Guangdong Justice Police Vocational College , Guangzhou , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology , Guangzhou Medical University Affiliated Stomatological Hospital , Guangzhou , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine , Nantong University , Nantong , Jiangsu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"2026092911585866455_j_med-2026-1501_ref_001","doi-asserted-by":"crossref","unstructured":"Kimura, H. 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