{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:34:18Z","timestamp":1786448058694,"version":"build-2736575974"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_med-2026-1504_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study examined associations between lipid profiles, anthropometric measures, and all-cause mortality in a Turkish adult cohort, stratified by\u00a0sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1504_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study analyzed 2,378 participants from the TEKHARF cohort over a median follow-up of 256\u00a0months (up to 25\u00a0years). All-cause mortality was evaluated using sex-specific Cox proportional hazards regression models and Restricted Cubic Spline analysis to\u00a0assess non-linear associations with baseline lipid parameters, anthropometric measures, and clinical risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1504_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During follow-up, 811 deaths (34.1\u202f%) occurred, with significantly higher mortality in males vs. females (37.5 vs. 30.6\u202f%, p&lt;0.001). Low income, physical inactivity, hypertension, and diabetes were strongly associated with\u00a0mortality in both sexes. In multivariate models, age, hypertension, and diabetes emerged as the most robust independent predictors of mortality. Although total cholesterol and LDL-C quartiles showed associations with mortality in unadjusted analyses, these became non-significant after adjustment. In males, HDL-C in the third quartile (Q3) was associated with a lower risk of mortality compared to the lowest quartile (HR: 0.759, p=0.045), whereas the highest triglyceride quartile independently predicted mortality only in males (HR: 1.464, p=0.008).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1504_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Traditional cardiometabolic risk factors, particularly age, hypertension, and diabetes, were the dominant mortality determinants. Notably, in males, triglycerides demonstrated a sex-specific independent effect on mortality risk, while intermediate HDL-C levels were associated with reduced mortality, emphasizing the importance of comprehensive risk assessment integrating lipid parameters with established clinical factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2026-1504","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:05:53Z","timestamp":1785920753000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of lipid profiles and risk factors on all-cause mortality in males and females: insights from a Turkish cohort study"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5925-2128","authenticated-orcid":false,"given":"Ugurcan","family":"Sayili","sequence":"first","affiliation":[{"name":"Department of Public Health, Cerrahpa\u015fa Faculty of Medicine , Istanbul University-Cerrahpa\u015fa , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3117-7760","authenticated-orcid":false,"given":"Busra","family":"Albayrak","sequence":"additional","affiliation":[{"name":"Department of Public Health, Cerrahpa\u015fa Faculty of Medicine , Istanbul University-Cerrahpa\u015fa , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-5763","authenticated-orcid":false,"given":"Kevser","family":"Sak","sequence":"additional","affiliation":[{"name":"Department of Public Health, Cerrahpa\u015fa Faculty of Medicine , Istanbul University-Cerrahpa\u015fa , Istanbul , T\u00fcrkiye"},{"name":"Dulkadiro\u011flu District Health Directorate , Republic of T\u00fcrkiye Ministry of Health , Kahramanmara\u015f , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5716-1193","authenticated-orcid":false,"given":"Aysem","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Institute of Cardiology, Istanbul University-Cerrahpa\u015fa , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5365-0950","authenticated-orcid":false,"given":"Osman Mutluhan","family":"Ugurel","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Cerrahpa\u015fa Faculty of Medicine , Istanbul University-Cerrahpa\u015fa , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5174-4606","authenticated-orcid":false,"given":"Mehmet Umut","family":"Capar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Cerrahpa\u015fa Faculty of Medicine , Istanbul University-Cerrahpa\u015fa , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2965-6102","authenticated-orcid":false,"given":"Aysen","family":"Fenercioglu","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Cerrahpa\u015fa Faculty of Medicine , Istanbul University-Cerrahpa\u015fa , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5815-6700","authenticated-orcid":false,"given":"Gunay","family":"Can","sequence":"additional","affiliation":[{"name":"Department of Public Health, Cerrahpa\u015fa Faculty of Medicine , Istanbul University-Cerrahpa\u015fa , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"2026081110570665536_j_med-2026-1504_ref_001","doi-asserted-by":"crossref","unstructured":"Kubo, K, Hirata, A, Kadota, A, Harada, A, Nakamura, Y, Hayakawa, T, et al.. 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