{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:45:52Z","timestamp":1791798352325,"version":"4.3.4"},"reference-count":50,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_med-2026-1546_abs_001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Malignant ascites (MA) impairs quality of life and remains difficult to control with symptomatic treatments. We summarize the rationale, uncertainties, and potential role of whole-peritoneal radiotherapy (WPRT) as an investigational palliative strategy for MA. The available evidence is limited, and no prospective or high-quality data currently establish WPRT as an effective treatment for\u00a0MA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1546_abs_002\">\n                    <jats:title>Content<\/jats:title>\n                    <jats:p>We conducted a narrative review of MA in the context of palliative radiotherapy, whole-abdominal and whole-peritoneal irradiation, technical feasibility, and treatment-related toxicity. Because no prospective or systematically designed studies have evaluated WPRT using ascites-specific endpoints, indirect evidence was included. An illustrative radiotherapy planning simulation in a model patient was also presented to demonstrate technical considerations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1546_abs_003\">\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Direct evidence supporting WPRT for symptom control in MA is lacking. However, the available literature provides a plausible rationale for this approach. Published literature supports the technical feasibility of large-field abdominal irradiation in selected oncological settings, but does not establish the feasibility, safety, or efficacy of WPRT specifically for\u00a0MA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_med-2026-1546_abs_004\">\n                    <jats:title>Outlook<\/jats:title>\n                    <jats:p>WPRT should be regarded as an investigational palliative approach supported by clinical rationale rather than evidence-based practice. WPRT may extend symptom-directed palliative radiotherapy to selected patients with MA, but its value requires prospective evaluation using ascites-specific endpoints.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/med-2026-1546","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:56:34Z","timestamp":1791795394000},"source":"Crossref","is-referenced-by-count":0,"title":["Whole peritoneal radiotherapy in malignant ascites: a hypothesis-generating conceptual review"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1361-9286","authenticated-orcid":false,"given":"Miros\u0142aw","family":"Kiedrowski","sequence":"first","affiliation":[{"name":"Department of Oncology , The National Medical Institute of the Ministry of the Interior and Administration , Warsaw , Poland"},{"name":"Ewdomed Hospice and Foundation , Konstancin-Jeziorna , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Ziemba","sequence":"additional","affiliation":[{"name":"Radiological Diagnostics Center , Department of Radiotherapy , The National Medical Institute of the Ministry of the Interior and Administration , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Banatkiewicz","sequence":"additional","affiliation":[{"name":"Radiological Diagnostics Center , Department of Radiotherapy , The National Medical Institute of the Ministry of the Interior and Administration , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemys\u0142aw","family":"Kapa\u0142a","sequence":"additional","affiliation":[{"name":"Ewdomed Hospice and Foundation , Konstancin-Jeziorna , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Szulecka","sequence":"additional","affiliation":[{"name":"Ewdomed Hospice and Foundation , Konstancin-Jeziorna , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Nurzy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Oncology , The National Medical Institute of the Ministry of the Interior and Administration , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"2026101208562683443_j_med-2026-1546_ref_001","doi-asserted-by":"crossref","unstructured":"Kastelein, AW, Vos, LMC, de Jong, KH, van Baal, JOAM, Nieuwland, R, van Noorden, CJF, et al.. 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