{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:01:58Z","timestamp":1779926518923,"version":"3.53.1"},"reference-count":9,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The landscape of haematological malignancies is constantly evolving, driven by advances in our understanding of their genetic basis. This has cumulated within the 5<jats:sup>th<\/jats:sup> Edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours published in short form in 2022 [1, 2] and being available in full length both as \u201cBlue Book\u201d (in print expected early 2024) as well as web-based classification (see: https:\/\/tumourclassification.iarc.who.int\/welcome\/). Similarly, the importance of genetic alterations for the classification is highlighted in other classification systems related to haematologic neoplasms [3\u20135]. In this special issue of the Medizinische Genetik, we present a comprehensive overview of the genetic alterations contributing to the classification of haematolymphoid neoplasms in the 5<jats:sup>th<\/jats:sup> Edition of the WHO classification (WHO-HAEM5) and its diagnostic relevance in the context of various haematological malignancies.<\/jats:p>","DOI":"10.1515\/medgen-2024-2008","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T07:43:33Z","timestamp":1709711013000},"page":"3-11","source":"Crossref","is-referenced-by-count":3,"title":["Overview on WHO-HAEM5 and the diagnostic relevance of genetic alterations for the classification"],"prefix":"10.1515","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-5049","authenticated-orcid":false,"suffix":"1","given":"Claudia","family":"Haferlach","sequence":"first","affiliation":[{"name":"MLL \u2013 Munich Leukemia Laboratory Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-6793","authenticated-orcid":false,"suffix":"2","given":"German","family":"Ott","sequence":"additional","affiliation":[{"name":"Robert-Bosch-Hospital Department for Clinical Pathology Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6276-614X","authenticated-orcid":false,"suffix":"1","given":"Katharina","family":"H\u00f6rst","sequence":"additional","affiliation":[{"name":"MLL \u2013 Munich Leukemia Laboratory Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7630-8545","authenticated-orcid":false,"suffix":"1","given":"Constanze","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"MLL \u2013 Munich Leukemia Laboratory Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0196-2837","authenticated-orcid":false,"suffix":"1","given":"Torsten","family":"Haferlach","sequence":"additional","affiliation":[{"name":"MLL \u2013 Munich Leukemia Laboratory Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6492-5323","authenticated-orcid":false,"suffix":"3","given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[{"name":"Ulm University Ulm University Medical Center Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"2024080804524285061_j_medgen-2024-2008_ref_001","doi-asserted-by":"crossref","unstructured":"Alaggio R et al. (2022) The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia. 36(7): p. 1720\u20131748","DOI":"10.1038\/s41375-022-01620-2"},{"key":"2024080804524285061_j_medgen-2024-2008_ref_002","doi-asserted-by":"crossref","unstructured":"Khoury J D et al. (2022) The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic\/Dendritic Neoplasms. Leukemia. 36(7): p. 1703\u20131719","DOI":"10.1038\/s41375-022-01613-1"},{"key":"2024080804524285061_j_medgen-2024-2008_ref_003","doi-asserted-by":"crossref","unstructured":"Arber D A et al. (2022) International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood. 140(11): p. 1200\u20131228","DOI":"10.1182\/blood.2022015850"},{"key":"2024080804524285061_j_medgen-2024-2008_ref_004","doi-asserted-by":"crossref","unstructured":"D\u00f6hner H et al. (2022) Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood. 140(12): p. 1345\u20131377","DOI":"10.1182\/blood.2022016867"},{"key":"2024080804524285061_j_medgen-2024-2008_ref_005","doi-asserted-by":"crossref","unstructured":"Campo E et al. (2022) The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee. Blood. 140(11): p. 1229\u20131253","DOI":"10.1182\/blood.2022015851"},{"key":"2024080804524285061_j_medgen-2024-2008_ref_006","unstructured":"WHO. WHO Classification of Tumours Editorial Board. Haematolymphoid tumours [Internet; beta version ahead of print]. WHO classification of tumours series 2022; 5th ed.; vol. 11:[Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/63]."},{"key":"2024080804524285061_j_medgen-2024-2008_ref_007","doi-asserted-by":"crossref","unstructured":"Bruford E A et al. (2021) HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions. Leukemia. 35(11): p. 3040\u20133043","DOI":"10.1038\/s41375-021-01436-6"},{"key":"2024080804524285061_j_medgen-2024-2008_ref_008","unstructured":"Swerdlow S H et al., WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. 2017, Lyon: International Agency for Research on Cancer (IARC)."},{"key":"2024080804524285061_j_medgen-2024-2008_ref_009","doi-asserted-by":"crossref","unstructured":"Hochhaus A et al. (2020) European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia. Leukemia. 34(4): p. 966\u2013984","DOI":"10.1038\/s41375-020-0776-2"}],"container-title":["Medizinische Genetik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/medgen-2024-2008\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/medgen-2024-2008\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T04:53:37Z","timestamp":1723092817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/medgen-2024-2008\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,4]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,3,6]]},"published-print":{"date-parts":[[2024,3,4]]}},"alternative-id":["10.1515\/medgen-2024-2008"],"URL":"https:\/\/doi.org\/10.1515\/medgen-2024-2008","relation":{},"ISSN":["1863-5490","0936-5931"],"issn-type":[{"value":"1863-5490","type":"electronic"},{"value":"0936-5931","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,4]]}}}