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The phenotypic spectrum of CMs ranges from silent heart failure to symptomatic heart failure and sudden cardiac death, and CMs are one of the leading causes of cardiovascular morbidity worldwide. CMs are highly heritable, although a clear distinction between inherited and acquired forms remains challenging, particularly due to observed incomplete penetrance and variable expressivity of inherited CMs. Based on their specific morphological phenotypes and functional characteristics, CMs can be divided into at least 5 different subgroups: hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic cardiomyopathy (ACM), restrictive cardiomyopathy (RCM), and (left ventricular) non-compaction cardiomyopathy (LVNC), which show both clinical as well as genetic overlap. Since the identification of pathogenic variants in\n                    <jats:italic>MYH7<\/jats:italic>\n                    as a genetic cause of HCM in 1990, enormous progress has been made in understanding genetic factors contributing to cardiomyopathies. Currently, over 100 genes have been associated with at least one of the CM subtypes, providing a deeper understanding of the cellular basis of genetic heart failure syndromes, unveiling new insights into the molecular biology of heart function in both health and disease, and, thereby, facilitating the development of novel therapeutic strategies and personalized treatment approaches.\n                  <\/jats:p>","DOI":"10.1515\/medgen-2025-2007","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T05:09:09Z","timestamp":1744088949000},"page":"103-111","source":"Crossref","is-referenced-by-count":2,"title":["Understanding inherited cardiomyopathies: clinical aspects and genetic determinants"],"prefix":"10.1515","volume":"37","author":[{"given":"G\u00f6khan","family":"Yigit","sequence":"first","affiliation":[{"name":"Institute of Human Genetics University Medical Center G\u00f6ttingen Heinrich-D\u00fcker-Weg 12 G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Kaulfu\u00df","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University Medical Center G\u00f6ttingen Heinrich-D\u00fcker-Weg 12 G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2589-0364","authenticated-orcid":false,"given":"Bernd","family":"Wollnik","sequence":"additional","affiliation":[{"name":"Georg-August University G\u00f6ttingen Institute of Human Genetics Heinrich-D\u00fcker-Weg 12 G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"2026051109204713684_j_medgen-2025-2007_ref_001","doi-asserted-by":"crossref","unstructured":"Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P, Dubourg O, K\u00fchl U, Maisch B, McKenna WJ, Monserrat L, Pankuweit S, Rapezzi C, Seferovic P, Tavazzi L, Keren A. 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