{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:27:23Z","timestamp":1777912043418,"version":"3.51.4"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polycystic ovary syndrome (PCOS) management mainly revolves around general lifestyle modifications that almost always include weight loss, an approach that fails to reflect the biological and ethnic diversity of the condition. Clinical and epidemiological evidences are suggestive of PCOS-associated metabolic and reproductive risk varying markedly across phenotypes and populations. These include obese, hyperandrogenic presentations to metabolically vulnerable women with lean-PCOS. Thus, universal lifestyle advice frequently delivers inconsistent or limited benefit. In this article, we propose a phenotype-guided and regionally informed approach to lifestyle intervention that incorporates hormonal, metabolic, and contextual factors, and this may allow PCOS care to move toward more precise and clinically meaningful intervention.<\/jats:p>","DOI":"10.1515\/mr-2026-0007","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:35:52Z","timestamp":1776443752000},"page":"162-165","source":"Crossref","is-referenced-by-count":0,"title":["Beyond weight loss: toward phenotype-guided, regionally calibrated interventions in polycystic ovary syndrome (PCOS)"],"prefix":"10.1515","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-5048","authenticated-orcid":false,"given":"Pallav","family":"Sengupta","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Medicine , 105956 Gulf Medical University , Ajman , United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7893-5282","authenticated-orcid":false,"given":"Sulagna","family":"Dutta","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences Department, College of Medicine , Ajman University , Ajman , United Arab Emirates"},{"name":"Centre of Medical and Bio-allied Health Sciences Research , Ajman University , Ajman , United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"2026050115424107592_j_mr-2026-0007_ref_001","doi-asserted-by":"crossref","unstructured":"Teede, HJ, Tay, CT, Laven, JJ, Dokras, A, Moran, LJ, Piltonen, TT, et al.. Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Eur J Endocrinol 2023;189:G43\u201364. https:\/\/doi.org\/10.1093\/ejendo\/lvad096.","DOI":"10.1210\/clinem\/dgad463"},{"key":"2026050115424107592_j_mr-2026-0007_ref_002","doi-asserted-by":"crossref","unstructured":"Motlagh Asghari, K, Nejadghaderi, SA, Alizadeh, M, Sanaie, S, Sullman, MJM, Kolahi, AA, et al.. Burden of polycystic ovary syndrome in the Middle East and North Africa region, 1990\u20132019. Sci Rep 2022;12:7039. https:\/\/doi.org\/10.1038\/s41598-022-11006-0.","DOI":"10.1038\/s41598-022-11006-0"},{"key":"2026050115424107592_j_mr-2026-0007_ref_003","doi-asserted-by":"crossref","unstructured":"Wijeyaratne, CN, Balen, AH, Barth, JH, Belchetz, PE. Clinical manifestations and insulin resistance (IR) in polycystic ovary syndrome (PCOS) among South Asians and caucasians: is there a difference? Clin Endocrinol 2002;57:343\u201350. https:\/\/doi.org\/10.1046\/j.1365-2265.2002.01603.x.","DOI":"10.1046\/j.1365-2265.2002.01603.x"},{"key":"2026050115424107592_j_mr-2026-0007_ref_004","doi-asserted-by":"crossref","unstructured":"Mehta, J, Kamdar, V, Dumesic, D. Phenotypic expression of polycystic ovary syndrome in South Asian women. Obstet Gynecol Surv 2013;68:228\u201334. https:\/\/doi.org\/10.1097\/ogx.0b013e318280a30f.","DOI":"10.1097\/OGX.0b013e318280a30f"},{"key":"2026050115424107592_j_mr-2026-0007_ref_005","doi-asserted-by":"crossref","unstructured":"de Loos, ALD, Jiskoot, G, Timman, R, Beerthuizen, A, Busschbach, JJV, Laven, JSE. Improvements in PCOS characteristics and phenotype severity during a randomized controlled lifestyle intervention. 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Questioning PCOS phenotypes for reclassification and tailored therapy. Trends Endocrinol Metabol 2023;34:694\u2013703. https:\/\/doi.org\/10.1016\/j.tem.2023.08.005.","DOI":"10.1016\/j.tem.2023.08.005"},{"key":"2026050115424107592_j_mr-2026-0007_ref_009","doi-asserted-by":"crossref","unstructured":"Wen, X, Wang, L, Bai, E. Metabolic characteristics of different phenotypes in reproductive-aged women with polycystic ovary syndrome. Front Endocrinol 2024;15:1370578. https:\/\/doi.org\/10.3389\/fendo.2024.1370578.","DOI":"10.3389\/fendo.2024.1370578"},{"key":"2026050115424107592_j_mr-2026-0007_ref_010","doi-asserted-by":"crossref","unstructured":"Singh, S, Pal, N, Shubham, S, Sarma, DK, Verma, V, Marotta, F, et al.. Polycystic ovary syndrome: etiology, current management, and future therapeutics. 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