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However, systemic toxicity and limited tumor selectivity continue to constrain their optimal integration with radiotherapy. Recent advances in radiation precision and metal chemistry are reshaping this landscape, giving rise to strategies in which radiotherapy and anticancer metallodrugs no longer act merely in combination, but intersect at the molecular level. Ionizing radiation generates highly reactive chemical species that can be harnessed to activate, modulate, or amplify the function of metallodrugs within irradiated tissues. Across platinum prodrugs, non-platinum metal complexes, and high-Z metal materials, radiation energy is increasingly exploited to achieve spatially confined cytotoxicity, immune modulation, and synergistic tumor control. Notably, radiometal-based drugs integrate radiochemistry with metal coordination chemistry, positioning themselves at the intersection of radiotherapy and metallodrug therapy, where they are already playing an increasingly important role in clinical oncology.<\/jats:p>","DOI":"10.1515\/mr-2026-0013","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:13:41Z","timestamp":1773782021000},"page":"166-169","source":"Crossref","is-referenced-by-count":0,"title":["Radiotherapy meets anticancer metallodrugs"],"prefix":"10.1515","volume":"6","author":[{"given":"Shuren","family":"Zhang","sequence":"first","affiliation":[{"name":"12465 Changping Laboratory , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyong","family":"Shen","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, College of Chemistry and Molecular Engineering, Peking University , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine , Key Laboratory of Carcinogenesis and Translational Research of Ministry of Education, Key Laboratory for Research and Evaluation of Radiopharmaceuticals of National Medical Products Administration, Peking University Cancer Hospital , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qunfeng","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Radiology , Molecular Imaging Program at Stanford, Stanford Medicine , Stanford , CA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijian","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), State Key Laboratory of Coordination Chemistry, Nanjing University , Nanjing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5587-4165","authenticated-orcid":false,"given":"Zhibo","family":"Liu","sequence":"additional","affiliation":[{"name":"12465 Changping Laboratory , Beijing , China"},{"name":"Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, College of Chemistry and Molecular Engineering, Peking University , Beijing , China"},{"name":"Department of Nuclear Medicine , Key Laboratory of Carcinogenesis and Translational Research of Ministry of Education, Key Laboratory for Research and Evaluation of Radiopharmaceuticals of National Medical Products Administration, Peking University Cancer Hospital , Beijing , China"},{"name":"Peking University-Tsinghua University Centre for Life Sciences, Peking University , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"2026050115424113938_j_mr-2026-0013_ref_001","doi-asserted-by":"crossref","unstructured":"Liu, J, Denkova, AG, Eelkema, R. 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