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This article systematically traces the evolution of jaw bone regeneration from conventional guided bone regeneration to bioactive scaffold\u2013based tissue engineering. Mechanism-driven strategies tailored for jaw bone regeneration under compromised bone microenvironment are also discussed, with a specific focus on diabetes. A clear understanding of the evolution of strategies for jaw bone regeneration and the challenges posed by impaired bone microenvironment will foster innovation in this field and improve clinical outcomes.<\/jats:p>","DOI":"10.1515\/mr-2026-0016","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:05:57Z","timestamp":1780092357000},"page":"262-265","source":"Crossref","is-referenced-by-count":1,"title":["Endogenous jaw bone regeneration: past, present, and future"],"prefix":"10.1515","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5385-0532","authenticated-orcid":false,"given":"Zhuoran","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Prosthodontics , Shanghai Ninth People\u2019s Hospital , Shanghai Jiao Tong University , Shanghai , China"},{"name":"College of Stomatology , Shanghai Jiao Tong University , Shanghai , China"},{"name":"National Center for Stomatology , National Clinical Research Center for Oral Diseases , Shanghai Key Laboratory of Stomatology , Shanghai Research Institute of Stomatology , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics , Shanghai Ninth People\u2019s Hospital , Shanghai Jiao Tong University , Shanghai , China"},{"name":"College of Stomatology , Shanghai Jiao Tong University , Shanghai , China"},{"name":"National Center for Stomatology , National Clinical Research Center for Oral Diseases , Shanghai Key Laboratory of Stomatology , Shanghai Research Institute of Stomatology , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"2026063011572891678_j_mr-2026-0016_ref_001","doi-asserted-by":"crossref","unstructured":"Helms, JA, Schneider, RA. 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