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The dependence on stoichiometric quantities of metals and often organic halides as precursors, in turn both produces copious amounts of metal halide wastes as well as leads to concerns on future metal sustainability. Inspired by the classical Wolff-Kishner reduction, our lab has recently developed a general strategy of <jats:bold>\n                     <jats:italic>HOME-Chemistry<\/jats:italic>\n                  <\/jats:bold>, directly using naturally abundant alcohols\/aldehydes and ketones as feedstocks with the releasing of innocuous water and nitrogen gas. These reactions include 1,2-carbonyl\/imine addition, conjugate addition, carboxylation, olefination, cross-coupling arylation\/allylation, alkylation, hydroalkylation and C-heteroatom formations. 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