{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T16:14:57Z","timestamp":1648916097944},"reference-count":15,"publisher":"Index Copernicus","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In cirrhotic hemophilia patients bleeding from esophageal varices is a serious clinical condition due to congenital deficiency of clotting factors VIII or IX, decreased prothrombin synthesis and hypersplenic thrombocytopenia. In hemophiliac with high-titer inhibitor bypassing therapy is required with activated prothrombin complex concentrates (aPCC) or recombinant activated coagulation factor VII (rFVIIa). Doses and duration treatment with these agents following endoscopic treatment of esophageal varices have not been yet established.<\/jats:p><jats:p>Authors report the first case of a severe hemophilia A patient with high titer inhibitor (40 BU) treated with repeated injection sclerotherapy. The patient was admitted with symptoms of massive esophageal variceal hemorrhage ceased with emergency sclerotherapy. Bypassing therapy was administered with aPCC at initial dose of 72.5 U\/kg and then with average daily dose of 162 U\/kg through 5 days. To achieved a total eradication of esophageal varices the patient was then subjected to four elective sclerotherapy procedures. Two were covered by aPCC with daily dose of 120 U\/kg and 145 U\/kg for 4 and 3 days respectively and the following two procedures were covered by rFVIIa with the initial dose of 116 \u00b5g\/kg and the next doses of 87 \u00b5g\/kg administered every 3 hours in procedure day and every 4 hours on the next two days. During all procedures excellent hemostasis was achieved and no hemorrhagic or thromboembolic complications were observed. Bypassing regimen therapy with aPCC and rFVIIa we applied have been shown to be safe and effective in this patient subjected to sclerotherapy procedures.<\/jats:p>","DOI":"10.1515\/pjs-2015-0089","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T14:50:04Z","timestamp":1453301404000},"source":"Crossref","is-referenced-by-count":0,"title":["Sclerotherapy Of Esophageal Varices In Severe Hemophilia A Patient And High Titer Inhibitor \u2013 Case Report"],"prefix":"10.5604","volume":"87","author":[{"given":"Andrzej B.","family":"Szczepanik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech P.","family":"D\u0105browski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Szczepanik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Pielaci\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Ja\u015bkowiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3689","reference":[{"key":"ref91","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1055\/s-2006-944566","article-title":"An evaluation of emergency sclerotherapy of varices in randomized trials : looking the needle in the eye","volume":"38","author":"Triantos","year":"2006","journal-title":"Endoscopy"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1365-2516.2004.00941.x","article-title":"Bet Consensus perspectives on surgery in haemophilia patients with inhibitor : summary statement","volume":"10","author":"Rodriguez","year":"2004","journal-title":"Haemophilia"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1160\/TH07-03-0198","article-title":"Haemostatic efficacy and safety of bolus and continous infusion of recombinant factor VIIa are comparable in haemophilia patients with inhibitors undergoing major surgery","volume":"98","author":"Pruthi","year":"2007","journal-title":"Thromb Haemost"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1443-1661.1999.tb00020.x","article-title":"A case of haemophilia B with esophageal varices treated by sclerotherapy with factor - 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risk gastroesophageal varices in a cirrhotic patient with hemophilia A","author":"Fukumoto","year":"2010","journal-title":"Gastroenterology Res Pract"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1055\/s-2007-1004182","article-title":"aroncini A prospective randomized trial of sclerotherapy versus ligation in the elective treatment of bleeding esophageal varices","volume":"29","author":"Milandri","year":"1997","journal-title":"Endoscopy"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2516.2010.02360.x","article-title":"Experience of four UK comprehensive care centers using FEIBA for surgeries in patient with inhibitors","volume":"17","author":"Rangarajan","year":"2011","journal-title":"Haemophilia"},{"key":"ref61","first-page":"209","article-title":"zczepanik Sclerotherapy of bleeding oesophageal varices in patients with haemophilia : personal experience","volume":"6","author":"Misiak","year":"2000","journal-title":"Haemophilia"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jvir.2006.12.731","article-title":"Safety and efficacy of TIPS in patients with hemophilia and cirrhosis","volume":"18","author":"Beime","year":"2007","journal-title":"J Vasc Interv Radiol"},{"key":"ref01","first-page":"1584","article-title":"End - stage liver disease in persons with hemophilia and transfusion related infections","volume":"100","author":"Goedert","year":"2002","journal-title":"Blood"}],"container-title":["Polish Journal of Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/view\/j\/pjs.2015.87.issue-9\/pjs-2015-0089\/pjs-2015-0089.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T17:29:13Z","timestamp":1567531753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/view\/j\/pjs.2015.87.issue-9\/pjs-2015-0089\/pjs-2015-0089.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":15,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.1515\/pjs-2015-0089","relation":{},"ISSN":["0032-373X"],"issn-type":[{"value":"0032-373X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}