{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:20:58Z","timestamp":1759335658487},"reference-count":0,"publisher":"Index Copernicus","issue":"6","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thyroid surgery is the most commonly performed procedure in the field of endocrine surgery. Studies are still ongoing on the development of a single algorithm for diagnosis and care of patients at risk of postoperative hypoparathyroidism.<\/jats:p><jats:p>was to determine the biochemical marker that would allow the most accurate diagnosis of patient groups at risk of developing hypoparathyroidism and to identify risk factors for this disorder.<\/jats:p><jats:p>The prospective study included 142 consecutive patients undergoing total thyroidectomy for benign goiter from January 1<\/jats:p><jats:p>Clinical symptoms of hypoparathyroidism developed in 25 (17.6%) of 142 patients. The best diagnostic accuracy for hypoparathyroidism based on ROC curves was obtained for iPTH at 6h (AUC 0.942; 95% CI: 0.866-1.000, p&lt;0.001) and its percentage change from baseline \u0394iPTH at 6h (AUC 0.930; 95% CI: 0.858-1.000, p&lt;0.001). In an multivariate analysis, the preoperative Ca level higher by 0.1 mmol\/l, and iPTH level higher by 0.1 pmol\/l were associated with a lower risk of hypoparathyroidism, by 68% (p=0.012) and 61% (p=0.007), respectively. A 1% decline in iPTH from baseline increased the risk of hypoparathyroidism by 15% (p&lt;0.001).<\/jats:p><jats:p>The most reliable markers indicating a high risk of postoperative hypoparathyroidism are the decline in \u0394iPTH at 6h by &gt; 65% or iPTH level at 6h &lt;1.57 pmol \/l. A postoperative decline in iPTH levels is an independent risk factor for the development of hypoparathyroidism. Preoperative higher concentrations of Ca and iPTH are protective factors for the development of this disorder.<\/jats:p>","DOI":"10.1515\/pjs-2016-0069","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T05:03:08Z","timestamp":1485925388000},"source":"Crossref","is-referenced-by-count":3,"title":["Early Predictors of Post \u2013 Thyroidectomy Hypoparathyroidism"],"prefix":"10.5604","volume":"88","author":[{"given":"Karol","family":"Sieniawski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Kaczka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Paduszy\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Fendler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart\u0142omiej","family":"Tomasik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lech","family":"Pomorski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3689","container-title":["Polish Journal of Surgery"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/pjs.2016.88.issue-6\/pjs-2016-0069\/pjs-2016-0069.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.degruyter.com\/view\/j\/pjs.2016.88.issue-6\/pjs-2016-0069\/pjs-2016-0069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T07:09:18Z","timestamp":1517382558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/view\/j\/pjs.2016.88.issue-6\/pjs-2016-0069\/pjs-2016-0069.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1515\/pjs-2016-0069","relation":{},"ISSN":["0032-373X"],"issn-type":[{"value":"0032-373X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,1]]}}}