{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:51:53Z","timestamp":1778824313968,"version":"3.51.4"},"reference-count":116,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The zebrafish (<jats:italic>Danio rerio<\/jats:italic>) has become known as an excellent model organism for studies of vertebrate biology, vertebrate genetics, embryonal development, diseases and drug screening. Nevertheless, there is still lack of detailed reports about usage of the zebrafish as a model in veterinary medicine. Comparing to other vertebrates, they can lay hundreds of eggs at weekly intervals, externally fertilized zebrafish embryos are accessible to observation and manipulation at all stages of their development, which makes possible to simplify the research techniques such as fate mapping, fluorescent tracer time-lapse lineage analysis and single cell transplantation. Although zebrafish are only 2.5 cm long, they are easy to maintain. Intraperitoneal and intracerebroventricular injections, blood sampling and measurement of food intake are possible to be carry out in adult zebrafish.<jats:italic>Danio rerio<\/jats:italic>is a useful animal model for neurobiology, developmental biology, drug research, virology, microbiology and genetics. A lot of diseases, for which the zebrafish is a perfect model organism, affect aquatic animals. For a part of them, like those caused by<jats:italic>Mycobacterium marinum<\/jats:italic>or<jats:italic>Pseudoloma neutrophila, Danio rerio<\/jats:italic>is a natural host, but the zebrafish is also susceptible to the most of fish diseases including Itch, Spring viraemia of carp and Infectious spleen and kidney necrosis. The zebrafish is commonly used in research of bacterial virulence. The zebrafish embryo allows for rapid, non-invasive and real time analysis of bacterial infections in a vertebrate host. Plenty of common pathogens can be examined using zebrafish model:<jats:italic>Streptococcus iniae, Vibrio anguillarum<\/jats:italic>or<jats:italic>Listeria monocytogenes.<\/jats:italic>The steps are taken to use the zebrafish also in fungal research, especially that dealing with<jats:italic>Candida albicans<\/jats:italic>and<jats:italic>Cryptococcus neoformans.<\/jats:italic>Although, the zebrafish is used commonly as an animal model to study diseases caused by external agents, it is also useful in studies of metabolic disorders including fatty liver disease and diabetes. The zebrafish is also a valuable tool as a model in behavioral studies connected with feeding, predator evasion, habituation and memory or lateralized control of behavior. The aim of the present article is to familiarize the reader with the possibilities of<jats:italic>Danio rerio<\/jats:italic>as an experimental model for veterinary medicine.<\/jats:p>","DOI":"10.1515\/pjvs-2015-0086","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T17:01:41Z","timestamp":1448902901000},"page":"663-674","source":"Crossref","is-referenced-by-count":30,"title":["Zebrafish: an animal model for research in veterinary medicine"],"prefix":"10.1515","volume":"18","author":[{"given":"N.","family":"Nowik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Podlasz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Jakimiuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kasica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Sienkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kaleczyc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref821","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1365-2761.2003.00467.x","article-title":"ML Transmission and tissue distribution ofPseudoloma neurophilia of rerio","volume":"26","author":"Kent","year":"2003","journal-title":"zebrafish J Fish Dis"},{"key":"ref731","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1365-2761.2011.01279.x","article-title":"anguillarumas a fish pathogen virulence factors diagnosis prevention","author":"Frans","year":"2011","journal-title":"J Fish Dis"},{"key":"ref811","first-page":"216","article-title":"Specification of zebrafish neural crest Results Differ","author":"Kelsh","year":"2002","journal-title":"Cell"},{"key":"ref1221","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0021-9150(71)90066-9","article-title":"Experimental atherosclerosis in the young bovine","volume":"14","author":"Wiggers","year":"1971","journal-title":"Atherosclerosis"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3354\/dao02145","article-title":"neurophiliainfections in zebrafish rerio effects of stress on survival growth reproduction","volume":"88","author":"Ramsay","year":"2009","journal-title":"Dis Aquat Organ"},{"key":"ref481","first-page":"37","article-title":"The first case of infectious spleen and kidney necrosis virus infection in aquarium - 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