{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:25:51Z","timestamp":1770135951264,"version":"3.49.0"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p> The implementation of new methods of osteoporotic therapy requires tests on animal model. The use of sheep as model has numerous advantages over other animals. The aim of this study was to describe the change in parameters in sheep with osteoporosis induced using steroids and ovariorectomy methods as opposed to the parameters in healthy sheep. The study was performed on female \u201emerinos\u201d breed sheep divided into the three groups: negative control (NC) - healthy animals, positive control (PC) - ovariorectomized animals and steroid control group (SC) - in which methylprednisolone was administered. This paper presents histological and ultrastructural examination with mechanical comparative tests for force\/strength values as well as indentation tests of joint cartilage. The obtained results confirm the loss of bone mass associated with mineral composition content in bones, which has an influence on bone strength.<\/jats:p>","DOI":"10.1515\/pjvs-2016-0014","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T17:35:28Z","timestamp":1461173728000},"page":"109-118","source":"Crossref","is-referenced-by-count":6,"title":["Experimental osteoporosis in sheep \u2013 mechanical and histological approach"],"prefix":"10.1515","volume":"19","author":[{"given":"Z.","family":"Kie\u0142bowicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pi\u0105tek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kuropka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mytnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nikodem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bie\u017cy\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Skrzypczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pezowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kuryszko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Reichert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref241","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/BRS.0b013e3181b8e0ff","article-title":"Glucocorticoid induced osteopenia in cancellous bone of sheep : validation of large animal model for spine fusion and biomaterial research","author":"Ding","year":"2010","journal-title":"Spine"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1002\/jbmr.5650111017","article-title":"The bisphosphonate tulidronate is a potent inhibitor of the osteoclast vacuolar","volume":"11","author":"David","year":"1996","journal-title":"J Bone Miner Res"},{"key":"ref21","article-title":"- induced inhibition of osteoblastic bone formation in ewes : a biomechanical and histomorphometric study","author":"Chavassieux","year":"1993","journal-title":"Int"},{"key":"ref01","first-page":"1","article-title":"An Introduction to Experimental Cartilage In An eds Handbook of Histology for Cartilage st ed Human pp","author":"Gruber HE","year":"2003","journal-title":"Bone Methods Bone"},{"key":"ref271","first-page":"130","article-title":"The ovariectomized sheep as a model for human bone loss Path","author":"Newton","year":"2004"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1002\/jbmr.5650111017","article-title":"The bisphosphonate tulidronate is a potent inhibitor of the osteoclast vacuolar","volume":"11","author":"David","year":"1996","journal-title":"J Bone Miner Res"},{"key":"ref191","first-page":"95","article-title":"von Bisphosphonates in medical practise actions - 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