{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T05:58:08Z","timestamp":1722923888211},"reference-count":86,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p> Cranberries and cranberry-derived diet supplements are often recommended for the treatment of urinary tract infections, also during pregnancy. These products contain strongly anti-angiogenic chemical compounds which could not be indifferent to the developing fetus. In the present work we evaluated the effect of feeding pregnant and lactating mice American cranberry extract (daily dose 0.88 mg) on the morphology and some parameters of spleen and kidney function of their adult progeny. Six weeks after delivery the morphometry of spleen and kidney, cytometric analysis of spleen lymphocytes, evaluation of humoral response to SRBC (Sheep Red Blood Cells), and examination of serum creatinine\/urea concentration, were performed in the offspring. Spleens of progeny from experimental (E) group differed from the spleens of progeny of control mice in the lower number of lymphatic nodules and their larger diameter. Cytometry of spleen cells from progeny of E mothers revealed more CD19<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> lymphocytes than in the control group. No difference was seen in the response to immunization by red blood cells of sheep (SRBC) between control and E offspring. An increase in the diameter of glomeruli was observed in the kidneys of the experimental group in comparison with the control group. No abnormalities in creatinine and urea serum level were observed. A higher concentration of VEGF and bFGF in E offspring sera in comparison to the controls was seen. Conclusion: Although the observed differences between the control and experimental group were not large, caution is recommended in using cranberries and their extracts during pregnancy until more research will be done on this topic.<\/jats:p>","DOI":"10.1515\/pjvs-2017-0009","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T10:02:20Z","timestamp":1495188140000},"page":"57-65","source":"Crossref","is-referenced-by-count":4,"title":["Morphometric abnormalities in spleen and kidney of the progeny of mice fed American cranberry extract (Vaccinium macrocarpon) during pregnancy and lactation"],"prefix":"10.1515","volume":"20","author":[{"given":"B.J.","family":"Ba\u0142an","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lewicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.K.","family":"Siwicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Stelmasiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Skopi\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Skopi\u0144ska-R\u00f3\u017cewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wasiuty\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Zdanowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref171","first-page":"371","article-title":"MS Modulation of angiogenic factors by ursolic acid","author":"Kiran","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref901","first-page":"115","article-title":"Inhibitory effects of catechin derivatives on mammalian DNA polymerase and topoisomerase activities and mouse one - 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rich foods in late pregnancy upon fetal ductus arteriosus Birth Defects Embryo","author":"Zielinsky","year":"2013","journal-title":"Res Today"},{"key":"ref281","first-page":"122","article-title":"Adenosine production by human cells and cell - mediated suppression of activated cells","author":"Saze","year":"2013","journal-title":"Blood"},{"key":"ref821","first-page":"57","article-title":"Chocolate feeding of pregnant mice influences length of limbs of their progeny","author":"Skopi\u0144ski","year":"2003","journal-title":"Pol J Vet Sci"},{"key":"ref321","first-page":"67","article-title":"a The influence of chocolate feeding of pregnant mice on the immunological response of their progeny Pol","volume":"13","author":"Skopi\u0144ska","year":"2004","journal-title":"J Food Nutr Sci"},{"key":"ref721","first-page":"192","article-title":"New insights into the role of extracellular matrix during tumor onset and progression","author":"Pupa","year":"2002","journal-title":"J Cell Physiol"},{"key":"ref191","first-page":"2015","article-title":"Spleen content of selected polyphenols splenocytes morphology and function in mice fed Rhodiola kirilowii extracts during pregnancy and lactation","volume":"18","author":"Lewicki","journal-title":"Pol J Vet Sci"},{"key":"ref331","first-page":"13","article-title":"acid feeding of pregnant and lactating mice influences the immune response of their progeny Pol","author":"Skopi\u0144ska","year":"2004","journal-title":"J Food Nutr Sci"},{"key":"ref291","first-page":"39","article-title":"Human CD CD regulatory cells produce adenosine upon co - expression of surface CD or contact with CD exosomes or CD cells","author":"Schuler","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"ref881","first-page":"800","article-title":"Inhibitory effect of cocoa catechins on embryonic and tumor angiogenesis in mice Pol Studies","volume":"14","author":"Wasiuty\u0144ski","year":"2005"},{"key":"ref541","first-page":"56","article-title":"In vivo inhibition of growth of human tumor lines by flavonoid fractions from cranberry extract","author":"Ferguson","year":"2006","journal-title":"Nutr Cancer"},{"key":"ref731","first-page":"1023","article-title":"Anti - angiogenic property of edible berries Free","author":"Roy","year":"2002","journal-title":"Res"},{"key":"ref241","first-page":"137","article-title":"Cranberry and its phytochemicals a review of in vitro anticancer studies","author":"Neto","year":"2007","journal-title":"J Nutr"},{"key":"ref391","first-page":"49","article-title":"Epicatechin gallate decreases the viability and subsequent embryonic development of mouse blastocysts","author":"Tu","year":"2010","journal-title":"Taiwan Obstet Gynecol"},{"key":"ref801","first-page":"203","article-title":"Lymphatic system of mice born from mothers treated with ampicillin or cloxacillin during gestation","author":"Skopi\u0144ska","year":"1985","journal-title":"Arch Ther"},{"key":"ref111","first-page":"69","article-title":"DR Cranberry urinary tract infections","author":"Guay","year":"2009","journal-title":"Drugs"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/ageing\/afi101","article-title":"Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital double blind placebo - 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