{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:52:48Z","timestamp":1758819168728},"reference-count":62,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,28]]},"abstract":"Abstract<\/jats:title>This study analysed the relaxant properties of salbutamol (\u03b22<\/jats:sub>-adrenoceptors agonist) and BRL 37344 (\u03b23<\/jats:sub>-adrenoceptors agonist) regarding the contractility of porcine myometrium on days 10-14 of the oestrous cycle (cyclic group; n = 10) and on days 3-5 of pregnancy (early pregnant group; n = 6). The activity of myometrial strips (tension, frequency and amplitude) was recorded under isometric conditions using force transducers. The contractility was assessed further following the administration of increasing concentrations of the agonists (10-9<\/jats:sup>-10-4<\/jats:sup>M), both with and without \u03b2-adrenoceptor antagonists (butaxamine - a selective \u03b22<\/jats:sub>- adrenoceptor antagonist, propranolol- a non-selective \u03b21<\/jats:sub>- and \u03b22<\/jats:sub>-adrenoceptor antagonist and bupranolol - a non-selective \u03b21<\/jats:sub>-, \u03b22<\/jats:sub>- and \u03b23<\/jats:sub>-adrenoceptor antagonist) at a concentration of 10-4<\/jats:sup>M. Although neither salbutamol nor BRL 37344 caused changes in the tension, at the highest concentrations they decreased the frequency and amplitude of contractions. These changes were more evident after salbutamol treatment and in the early pregnant group. Antagonists given alone did not cause changes in the parameters examined but changed some activity of the agonists. Butoxamine reduced the decrease in frequency and amplitude induced by salbutamol and produced a decrease in the tension after BRL 37344 treatment in the early pregnant group. Propranolol reduced the decrease in frequency and amplitude induced by salbutamol in both examined groups and did not cause significant changes in BRL 37344 activity. The administration of bupranolol before salbutamol treatment caused an increase in the tension and reduced the decrease in the frequency in the cyclic group. Moreover, bupranolol eliminated a decrease in frequency and induced an increase in amplitude caused by BRL 37344 in both groups and these changes were more evident in the early pregnant group. The data indicates that both \u03b22- and \u03b23-adenoreceptors are involved in the regulation of the contractility in both groups, but the changes after agonists and antagonists treatment are more evident in the early pregnant myometrium.<\/jats:p>","DOI":"10.1515\/pjvs-2017-0015","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T10:02:20Z","timestamp":1495188140000},"page":"111-121","source":"Crossref","is-referenced-by-count":6,"title":["Influence of \u03b22- and \u03b23-adrenoceptor agonists on contractile activity of the porcine myometrium in the luteal phase and the first days of pregnancy"],"prefix":"10.1515","volume":"20","author":[{"given":"W.","family":"Markiewicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.","family":"Jaroszewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref151","first-page":"151","article-title":"In vitro contractile activity of porcine myometrium during luteolysis and early pregnancy : effect of oxytocin and progesterone","author":"Kurowicka","year":"2005","journal-title":"Reprod Biol"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1210\/jc.2004-0233","article-title":"Beta - 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vitro fertilization","volume":"13","author":"Fanchin","year":"1998","journal-title":"Hum Reprod"},{"key":"ref341","first-page":"1","article-title":"Is the beta adrenoceptor a potential target for uterorelaxant drugs Pregnancy Childbirth","volume":"14","author":"Bardou","year":"2007"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.2527\/jas.2016-0577","article-title":"\u03b2 and \u03b2 adrenergic receptors stimulation relaxes porcine myometrium in the peri - implantation period","author":"Markiewicz","year":"2016","journal-title":"J Anim Sci"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1210\/jc.2004-0233","article-title":"Beta - adrenoceptor is the predominant beta - adrenoceptor subtype in human myometrium and its expression is up - regulated in pregnancy","author":"Rouget","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref361","first-page":"573","article-title":"The effects and selectivity of beta - adrenoceptor agonists in rat myometrium and urinary bladder","author":"Clouse","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"ref501","first-page":"261","article-title":"Normal cyclical morphology of the endometrium and ovary of swine","volume":"16","author":"Leiser","year":"1988","journal-title":"Tierarztl Prax"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1600-0773.1979.tb02307.x","article-title":"Beta - adrenoceptors in the pregnant and non - pregnant myometrium of the goat and cow","author":"Larsen","year":"1979","journal-title":"Acta Pharmacol Toxicol"},{"key":"ref351","first-page":"442","article-title":"In vitro pharmacological characterization of the prostanoid receptor population in the non - pregnant porcine myometrium","author":"Cao","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"ref291","first-page":"59","article-title":"The beta adrenoceptor as a therapeutic target current perspectives","author":"Ursino","year":"2009","journal-title":"Pharmacol Res"},{"key":"ref331","first-page":"130","article-title":"Functional biochemical and molecular biological evidence for a possible beta adrenoceptor in human near - term myometrium","author":"Bardou","year":"2000","journal-title":"Pharmacol"},{"key":"ref131","first-page":"469","article-title":"Pregnancy - associated changes in responsiveness of the porcine myometrium to bioactive substances","author":"Kitazawa","year":"2003","journal-title":"Eur J Pharmacol"}],"container-title":["Polish Journal of Veterinary Sciences"],"original-title":[],"link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/pjvs\/20\/1\/article-p111.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.degruyter.com\/view\/j\/pjvs.2017.20.issue-1\/pjvs-2017-0015\/pjvs-2017-0015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T06:38:41Z","timestamp":1719211121000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.pan.pl\/dlibra\/publication\/121066\/edition\/105467\/content"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,28]]},"references-count":62,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1515\/pjvs-2017-0015","relation":{},"ISSN":["2300-2557"],"issn-type":[{"value":"2300-2557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,28]]}}}