{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T07:28:17Z","timestamp":1648970897806},"reference-count":52,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p> Lymphocytic infiltrations located in the extracellular matrix often accompany canine skin cancer. They can be characterised as an inflammatory infiltration and\/or a second tumour - lymphoma. The aim of this study was an immunohistochemical analysis of a lymphocytic infiltration which accompanies spontaneous skin cancer. Twenty basal cell carcinoma, 20 non-keratinizing squamous cell carcinoma, 20 keratinizing squamous cell carcinoma and 8 sebaceous gland carcinoma samples which were accompanied by a lymphocytic infiltration and\/or secondary lymphatic follicles were verified histopathologically. The expression of bcl-2, CD3, CD79\u03b1, Ki-67, MCM-3 and MCM-7 in the lymphocytic infiltration was evaluated. Four types of lymphocytic infiltrations were found: I - diffuse bcl-2<jats:sup>+<\/jats:sup>, II - diffuse bcl-2<jats:sup>-<\/jats:sup>, III - follicular bcl-2<jats:sup>+\/-<\/jats:sup> where the centre was bcl-2<jats:sup>-<\/jats:sup>, and the marginal zone of the follicles and the extrafollicular area were bcl-2<jats:sup>+<\/jats:sup> and IV - aggregated bcl-2<jats:sup>+<\/jats:sup>, where the centre and periphery were bcl-2<jats:sup>+<\/jats:sup>. The I and IV type corresponds to lymphoma, II type is non-neoplastic immune response and III type suggest reactive follicular hyperplasia. The proliferation of lymphocytes which demonstrated the expression of neoplastic markers (I and IV), suggests preneoplastic phase (pseudolymphoma) or lymphoma - the second independent tumour. A high proliferative index of the follicular blc-2<jats:sup>+\/-<\/jats:sup> follicular infiltration indicates an increased immunological response of the host against skin cancer.<\/jats:p>","DOI":"10.1515\/pjvs-2017-0018","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T10:02:20Z","timestamp":1495188140000},"page":"141-147","source":"Crossref","is-referenced-by-count":1,"title":["An immunohistochemical analysis of lymphocytic infiltrations in canine skin cancers"],"prefix":"10.1515","volume":"20","author":[{"given":"J.A.","family":"Madej","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.","family":"Madej","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dzimira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref191","first-page":"14","article-title":"Isolated Follicles Enriched for Centroblasts and Lacking in Tissue Diagnostic and Clinical Implications One","volume":"11","author":"Nybakken","year":"2016"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5326\/0460020","article-title":"Multiple distinct malignancies in dogs cases","volume":"46","author":"Rebhun","year":"2010","journal-title":"J Am Anim Hosp Assoc"},{"key":"ref381","first-page":"1","article-title":"Tumor - 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