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The maximum concentration and area under the curve in large-breed dogs orally administered 2 mg\/kg PDS were significantly greater than those in small-breed dogs given 2 mg\/kg and in large-breed dogs given 40 mg\/m2. The higher blood concentrations that result from BW-based dosing of oral PDS in large-breed dogs can be more than required for effect. Meanwhile, BSA dosing at 40 mg\/m may be suboptimal. These findings confirm important differences between standard PDS dosing schemes in dogs while highlighting the need to further optimize PDS dosing in large-breed dogs.<\/jats:p>","DOI":"10.1515\/pjvs-2017-0076","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T17:16:29Z","timestamp":1511370989000},"page":"611-613","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of body surface area-based and weight-based dosing format for oral prednisolone administration in small and large-breed dogs"],"prefix":"10.1515","volume":"20","author":[{"given":"A.","family":"Nam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.W.","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.H.","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.S.","family":"Koo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.W.","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref141","first-page":"73","article-title":"der Influence of Pglycoprotein modulation on plasma concentrations and pharmacokinetics of orally administered prednisolone in dogs","author":"Van","year":"2012","journal-title":"Am J Vet Res"},{"key":"ref01","first-page":"124","article-title":"needs of companion animals : matching food intakes to requirements throughout the life cycle","volume":"12","author":"Burger","year":"1994","journal-title":"Energy J Nutr"},{"key":"ref101","first-page":"101","article-title":"Estimation of body surface area in various childhood ages - 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