{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:21:04Z","timestamp":1790198464824,"version":"4.1.0"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is a drug delivery technique with superior pharmacological properties for treating peritoneal metastasis (PM). Adding electrostatic loading (\n                    <jats:italic>e<\/jats:italic>\n                    PIPAC) as an adjunct to aerosol and artificial hydrostatic pressure improved tissue uptake in a preclinical model.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : We report the first\n                    <jats:italic>e<\/jats:italic>\n                    PIPAC use in 3 patients with PM of hepatobiliary-pancreatic (HBP) origin. All 3 patients received concomitant palliative systemic chemotherapy that was discontinued in two patients. PIPAC with cisplatin 7.5 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    and doxorubicin 1.5 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    was applied intraperitoneally at a pressure of 12 mmHg and a temperature of 37%\u2006\u00b0C for 30 min. Additionally, a voltage 7,500\u20139,500 V and a current\u226410 \u00b5A were applied over a stainless steel brush electrode emitting a stream of electrons.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    :\n                    <jats:italic>e<\/jats:italic>\n                    PIPAC was technically feasible. No intraoperative complication was noted. The procedures were well tolerated with no adverse event CTCAE\u2006&gt;\u20062. Patient 1 with PM of unknown origin (CUP with HBP phenotype) showed an objective histological and radiological response and survived 11 months. Patient 2 with ductal pancreatic cancer underwent secondary resection after ePIPAC with no residual PM; however, tumor recurred 5 months later. Patient 3 with adenocarcinoma of the gallbladder showed a radiological regression of liver infiltration and is alive after 22 months without histological evidence of PM.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : ePIPAC is technically feasible, is well tolerated and can induce tumor regression of PM in HBP cancers with and without concomitant systemic chemotherapy. These preliminary results justify prospective clinical studies with ePIPAC.\n                  <\/jats:p>","DOI":"10.1515\/pp-2016-0005","type":"journal-article","created":{"date-parts":[[2016,6,19]],"date-time":"2016-06-19T06:01:36Z","timestamp":1466316096000},"page":"109-116","source":"Crossref","is-referenced-by-count":46,"title":["Electrostatic precipitation Pressurized IntraPeritoneal Aerosol Chemotherapy (ePIPAC): first in-human application"],"prefix":"10.1515","volume":"1","author":[{"given":"Marc","family":"Reymond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Demtroeder","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Ruhr-University Bochum, Herne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Solass","sequence":"additional","affiliation":[{"name":"Medical School Hanover, Institute of Pathology, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Winnekendonk","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ruhr-University Bochum, Herne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Tempfer","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Ruhr-University Bochum, Herne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2016,4,29]]},"reference":[{"key":"2025120909210680938_j_pp-2016-0005_ref_001_w2aab3b7b1b1b6b1ab1b4b1Aa","doi-asserted-by":"crossref","unstructured":"1. 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Gynecol Oncol 2014 Feb;132:307\u201311.","DOI":"10.1016\/j.ygyno.2013.11.022"},{"key":"2025120909210680938_j_pp-2016-0005_ref_011_w2aab3b7b1b1b6b1ab1b4c11Aa","doi-asserted-by":"crossref","unstructured":"11. Nadiradze G, Giger-Pabst U, Zieren J, Strumberg D, Solass W, Reymond MA. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) with Low-Dose Cisplatin and Doxorubicin in Gastric Peritoneal Metastasis. J Gastrointest Surg 2015 Oct 28. [Epub ahead of print].","DOI":"10.1007\/s11605-015-2995-9"},{"key":"2025120909210680938_j_pp-2016-0005_ref_012_w2aab3b7b1b1b6b1ab1b4c12Aa","doi-asserted-by":"crossref","unstructured":"12. Demtr\u00f6der C, Solass W, Zieren J, Strumberg D, Giger-Pabst U, Reymond MA. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) with oxaliplatin in colorectal peritoneal metastasis. Colorectal Dis 2015 Sep 24. [Epub ahead of print].","DOI":"10.1111\/codi.13130"},{"key":"2025120909210680938_j_pp-2016-0005_ref_013_w2aab3b7b1b1b6b1ab1b4c13Aa","doi-asserted-by":"crossref","unstructured":"13. Tempfer CB, Winnekendonk G, Solass W, Horvat R, Giger-Pabst U, Zieren J, et al. Pressurized intraperitoneal aerosol chemotherapy in women with recurrent ovarian cancer: A phase 2 study. Gynecol Oncol 2015 May;137:223\u20138.","DOI":"10.1016\/j.ygyno.2015.02.009"},{"key":"2025120909210680938_j_pp-2016-0005_ref_014_w2aab3b7b1b1b6b1ab1b4c14Aa","unstructured":"14. Study of Efficacy and Safety of Laparoscopic Intra-abdominal Chemotherapy (PIPAC) Performed in Patients With Peritoneal Carcinomatosis From Colorectal, Ovarian, Gastric Cancer and Primary Peritoneal Tumors (PI-CaP). NCT0260478, www.clincialtrials.gov, Accessed Feb 22, 2016."},{"key":"2025120909210680938_j_pp-2016-0005_ref_015_w2aab3b7b1b1b6b1ab1b4c15Aa","unstructured":"15. 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