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The parietal peritoneum accounts for about 30\u2006% of the peritoneal surface (anterior abdominal wall 4\u2006%) and is vascularized from the circumflex, iliac, lumbar, intercostal, and epigastric arteries, giving rise to a quadrangular network of large, parallel blood vessels and their perpendicular offshoots. Parietal vessels drain into the inferior vena cava. The visceral peritoneum accounts for 70\u2006% of the peritoneal surface and derives its blood supply from the three major arteries that supply the splanchnic organs, celiac and superior and inferior mesenteric. These vessels give rise to smaller arteries that anastomose extensively. The visceral peritoneum drains into the portal vein. Drugs absorbed are subject to first-pass hepatic metabolism. Peritoneal inflammation and cancer invasion induce neoangiogenesis, leading to the development of an important microvascular network. Anatomy of neovessels is abnormal and characterized by large size, varying diameter, convolution and blood extravasation. Neovessels have a defective ultrastructure: formation of large \u201cmother vessels\u201d requires degradation of venular and capillary basement membranes. Mother vessels give birth to numerous \u201cdaughter vessels\u201d. Diffuse neoangiogenesis can be observed before appearance of macroscopic peritoneal metastasis. Multiplication of the peritoneal capillary surface by neoangiogenesis surface increases the part of cardiac outflow directed to the peritoneum.<\/jats:p>","DOI":"10.1515\/pp-2016-0015","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T06:56:00Z","timestamp":1475564160000},"page":"145-158","source":"Crossref","is-referenced-by-count":76,"title":["Functional vascular anatomy of the peritoneum in health and disease"],"prefix":"10.1515","volume":"1","author":[{"given":"Wiebke","family":"Solass","sequence":"first","affiliation":[{"name":"Institute of Pathology, Medical School Hannover , Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Horvath","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery , Eberhard-Karls-Universitat Tubingen Medizinische Fakultat , Tuebingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Struller","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery , Eberhard-Karls-Universitat Tubingen Medizinische Fakultat , Tuebingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingmar","family":"K\u00f6nigsrainer","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery , Eberhard-Karls-Universitat Tubingen Medizinische Fakultat , Tuebingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Beckert","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery , Eberhard-Karls-Universitat Tubingen Medizinische Fakultat , Tuebingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"K\u00f6nigsrainer","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery , Eberhard-Karls-Universitat Tubingen Medizinische Fakultat , Tuebingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank-J\u00fcrgen","family":"Weinreich","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery , Eberhard-Karls-Universitat Tubingen Medizinische Fakultat , Tuebingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schenk","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery , Eberhard-Karls-Universitat Tubingen Medizinische Fakultat , Tuebingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2016,10,4]]},"reference":[{"key":"2025120909192066345_j_pp-2016-0015_ref_001_w2aab3b7c12b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Reymond MA. 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