{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:22:20Z","timestamp":1791649340820,"version":"4.3.4"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_pp-2016-0019_s_001_w2aab3b8b7b1b7b1aab1c14b1Aa\"><jats:title><jats:bold>Background<\/jats:bold>:<\/jats:title><jats:p>Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is an innovative technique for intraperitoneal drug delivery. This study investigates the efficacy of the occupational health safety measures taken to prevent exposition of healthcare workers to the toxic chemotherapy aerosol.<\/jats:p><\/jats:sec><jats:sec id=\"j_pp-2016-0019_s_002_w2aab3b8b7b1b7b1aab1c14b2Aa\"><jats:title><jats:bold>Methods<\/jats:bold>:<\/jats:title><jats:p>Air samples were taken at the working place of the surgeon and of the anesthetist during 2 PIPAC procedures and analyzed for content of platinum by inductively coupled plasma mass spectrometry (ICP-MS). Airborne particles were quantified in real time. Biological monitoring was performed in two surgeons after 50 PIPAC by examining blood samples for possible traces of platinum. Analysis was performed by an independent company.<\/jats:p><\/jats:sec><jats:sec id=\"j_pp-2016-0019_s_003_w2aab3b8b7b1b7b1aab1c14b3Aa\"><jats:title><jats:bold>Results<\/jats:bold>:<\/jats:title><jats:p>Safety measures included tightly closed abdomen, operating room (OR), ventilation meeting requirements of ISO norm 14644\u20131 class 5, closed aerosol waste system and remote control of PIPAC administration. No traces of platinum were found in the air of the OR (detection limit of 0.0001\u2009mg\/filter). No specific rise in particle concentration was detected in the air during the PIPAC procedure, patient closure and removal of the sterile drapes. Blood samples of the surgeons showed no traces of platinum.<\/jats:p><\/jats:sec><jats:sec id=\"j_pp-2016-0019_s_004_w2aab3b8b7b1b7b1aab1c14b4Aa\"><jats:title><jats:bold>Conclusions<\/jats:bold>:<\/jats:title><jats:p>After implementation of adequate safety measures, no signs of environmental contamination or biological exposure of the surgeons were detected during PIPAC.<\/jats:p><\/jats:sec>","DOI":"10.1515\/pp-2016-0019","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T09:50:28Z","timestamp":1480067428000},"page":"203-208","source":"Crossref","is-referenced-by-count":38,"title":["Environmental safety during the administration of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)"],"prefix":"10.1515","volume":"1","author":[{"given":"Martin","family":"Graversen","sequence":"first","affiliation":[{"name":"1Upper GI & HPB Section, Department of Surgery, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"2Department of Water and Environment, Life Science, Danish Technological Institute, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Mortensen","sequence":"additional","affiliation":[{"name":"1Upper GI & HPB Section, Department of Surgery, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref371","article-title":"In vivo feasibility of electrostatic precipitation as an adjunct to pressurized intraperitoneal aerosol chemotherapy (ePIPAC)","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s00464-012-2148-0","article-title":"Description of a novel approach for intraperitoneal drug delivery and the related device","volume":"26","year":"2012","journal-title":"Surg Endosc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/codi.13130","article-title":"Pressurized intraperitoneal aerosol chemotherapy with oxaliplatin in colorectal peritoneal metastasis","volume":"18","year":"2016","journal-title":"Colorectal Dis"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ygyno.2015.02.009","article-title":"Pressurized intraperitoneal aerosol chemotherapy in women with recurrent ovarian cancer: A phase 2 study","volume":"137","year":"2015","journal-title":"Gynecol Oncol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ygyno.2013.11.022","article-title":"Activity of pressurized intraperitoneal aerosol chemotherapy (PIPAC) with cisplatin and doxorubicin in women with recurrent, platinum-resistant ovarian cancer: preliminary clinical experience","volume":"132","year":"2014","journal-title":"Gynecol Oncol"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ygyno.2013.11.022","article-title":"Activity of pressurized intraperitoneal aerosol chemotherapy (PIPAC) with cisplatin and doxorubicin in women with recurrent, platinum-resistant ovarian cancer: preliminary clinical experience","volume":"132","year":"2014","journal-title":"Gynecol Oncol"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1007\/s00464-015-4738-0","article-title":"Feasibility of hyperthermic pressurized intraperitoneal aerosol chemotherapy in a porcine model","volume":"30","year":"2016","journal-title":"Surg Endosc"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.soc.2012.07.001","article-title":"Hyperthermic intraperitoneal chemotherapy: methodology and safety considerations","volume":"21","year":"2012","journal-title":"Surg Oncol Clin North 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intraperitoneal aerosol chemotherapy \u2013 cancer under pressure","year":"2014"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/jso.21740","article-title":"Evaluation of environmental contamination by platinum and exposure risks for healthcare workers during a heated intraperitoneal perioperative chemotherapy (HIPEC) procedure","volume":"103","year":"2011","journal-title":"J Surg Oncol"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1039\/B205132J","article-title":"Exposure to anti-cancer drugs during preparation and administration. 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