{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:14:24Z","timestamp":1777544064059,"version":"3.51.4"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is a drug delivery system for treatment of peritoneal metastasis (PM). A limitation of this technique is the non-access rate (10\u201315\u2006%) due to peritoneal adhesions. The aim of the study was to assess feasibility and safety of the single-port access technique for PIPAC.<\/jats:p><\/jats:sec>Methods<\/jats:title>Single-center, pilot study. Case series, retrospective analysis on 17 patients with PM of various origin treated with intraperitoneal cisplatin, doxorubicin and\/or oxaliplatin administered as PIPAC. Single-port access was attempted in all patients by minilaparotomy.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty-nine PIPAC procedures were performed. Nine patients were subjected to 1 PIPAC, four patients to 2 PIPAC and four patients to 3 PIPAC. Access to peritoneal cavity was possible in all cases. There was no bowel access lesion. Tightness of the abdomen (CO2<\/jats:sub>-flow\u2009=\u20090) was achieved in all cases. No postoperative complications according to CTCAE (Common Terminology Criteria for Adverse Events)>2 were observed, no re-laparotomies required and no postoperative mortality recorded.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Single port-access is feasible and safe for PIPAC. Potential advantages over multiple trocars technique are a lower non-access rate, a lower risk of bowel lesions and a better tightness of the abdomen. This has now to be confirmed in a comparative study.<\/jats:p><\/jats:sec>","DOI":"10.1515\/pp-2016-0021","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T10:03:33Z","timestamp":1482833013000},"page":"217-222","source":"Crossref","is-referenced-by-count":12,"title":["Single-port access for Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC): technique, feasibility and safety"],"prefix":"10.1515","volume":"1","author":[{"given":"Marco","family":"Vaira","sequence":"first","affiliation":[{"name":"1Unit of Surgical Oncology, Candiolo Cancer Institute \u2013 FPO, IRCCS, Candiolo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Robella","sequence":"additional","affiliation":[{"name":"1Unit of Surgical Oncology, Candiolo Cancer Institute \u2013 FPO, IRCCS, Candiolo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Borsano","sequence":"additional","affiliation":[{"name":"1Unit of Surgical Oncology, Candiolo Cancer Institute \u2013 FPO, IRCCS, Candiolo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"De Simone","sequence":"additional","affiliation":[{"name":"1Unit of Surgical Oncology, Candiolo Cancer Institute \u2013 FPO, IRCCS, Candiolo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s004649900010","article-title":"Feasibility of therapeutic pneumoperitoneum in a large animal model using a microvaporisator","volume":"14","year":"2000","journal-title":"Surg Endosc"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ygyno.2013.11.022","article-title":"Activity of pressurized intraperitoneal aerosol chemotherapy (PIPAC) 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