{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:36:36Z","timestamp":1790339796832,"version":"4.1.0"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,27]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Pressurised intraperitoneal aerosol chemotherapy (PIPAC) is a novel technique of intraperitoneal chemotherapy devoted to unresectable peritoneal metastasis (PM). The first results obtained with PIPAC in preclinical models of colon cancer are presented here.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In vitro<\/jats:italic>\n , PIPAC (normotherm oxaliplatin at 0.028\u2006mg\/mL for 10\u2006min at 1.6 bars) and HIPEC (hyperthermic oxaliplatin at 0.14\u2006mg\/mL for 30\u2006min) were compared using the apoptosis and proliferation assay on two colon cancer cell lines (LS 174 and CT 26);\n ex vivo<\/jats:italic>\n tumours from an orthotopic mouse model of PM and non-tumour peritoneum from a patient treated according to the two modalities were assessed, investigating the percentage of penetration of oxaliplatin in the tumour and oxaliplatin concentration below the peritoneum.\n In vivo<\/jats:italic>\n , a mouse model of colon (CT 26) PM was used to create a PIPAC model (same modalities) for the comparison of IV oxaliplatin (at 5\u2006mg\/mL).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In vitro<\/jats:italic>\n , the rate of apoptotic and proliferative cells as well as the level of oxaliplatin penetration in tumour nodes was higher in PIPAC groups with less systemic passage through the peritoneum.\n In vivo<\/jats:italic>\n , in the colon PM mouse model, the peritoneal cancer index (PCI) was decreased to the same level using PIPAC or IV oxaliplatin. Systemic passage was lower in the PIPAC group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n PIPAC with low-dose oxaliplatin is efficient in both\n in vitro<\/jats:italic>\n and\n in vivo<\/jats:italic>\n models of colon PM. Lower concentrations of chemotherapy are needed in PIPAC to achieve the same effect as IV chemotherapy on PCI. With a very low systemic oxaliplatin passage, this technique of drug delivery seems to be as effective as IV delivery for PM control.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/pp-2017-0015","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T09:20:19Z","timestamp":1496395219000},"page":"103-109","source":"Crossref","is-referenced-by-count":38,"title":["Experimental pharmacokinetics evaluation of chemotherapy delivery by PIPAC for colon cancer: first evidence for efficacy"],"prefix":"10.1515","volume":"2","author":[{"given":"Clarisse","family":"Eveno","sequence":"first","affiliation":[{"name":"Department of Oncologic & Digestive Surgery , AP-HP, Hospital Lariboisi\u00e8re , Paris Cedex 10 , France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, CART, Carcinomatosis Angiogenesis Translational Research, INSERM U965 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aminata","family":"Haidara","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, CART, Carcinomatosis Angiogenesis Translational Research, INSERM U965 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Ali","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, CART, Carcinomatosis Angiogenesis Translational Research, INSERM U965 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Pimpie","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, CART, Carcinomatosis Angiogenesis Translational Research, INSERM U965 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massoud","family":"Mirshahi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, CART, Carcinomatosis Angiogenesis Translational Research, INSERM U965 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pocard","sequence":"additional","affiliation":[{"name":"Department of Oncologic & Digestive Surgery , AP-HP, Hospital Lariboisi\u00e8re , 2 rue Ambroise Par\u00e9, 75475 Paris Cedex 10 , France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, CART, Carcinomatosis Angiogenesis Translational Research, INSERM U965 , 74575 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"2025120909204643835_j_pp-2017-0015_ref_001_w2aab3b7c38b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Solass W, Kerb R, M\u00fcrdter T, Giger-Pabst U, Strumberg D, Tempfer C, et al. 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