{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:21:07Z","timestamp":1790198467122,"version":"4.1.0"},"reference-count":152,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peritoneal response to various kinds of injury involves loss of peritoneal mesothelial cells (PMC), danger signalling, epithelial-mesenchymal transition and mesothelial-mesenchymal transition (MMT). Encapsulating peritoneal sclerosis (EPS), endometriosis (EM) and peritoneal metastasis (PM) are all characterized by hypoxia and formation of a vascularized connective tissue stroma mediated by vascular endothelial growth factor (VEGF). Transforming growth factor-\u03b21 (TGF-\u03b21) is constitutively expressed by the PMC and plays a major role in the maintenance of a transformed, inflammatory micro-environment in PM, but also in EPS and EM. Persistently high levels of TGF-\u03b21 or stimulation by inflammatory cytokines (interleukin-6 (IL-6)) induce peritoneal MMT, adhesion formation and fibrosis. TGF-\u03b21 enhances hypoxia inducible factor-1\u03b1 expression, which drives cell growth, extracellular matrix production and cell migration. Disruption of the peritoneal glycocalyx and exposure of the basement membrane release low molecular weight hyaluronan, which initiates a cascade of pro-inflammatory mediators, including peritoneal cytokines (TNF-\u03b1, IL-1, IL-6, prostaglandins), growth factors (TGF-\u03b1, TGF-\u03b2, platelet-derived growth factor, VEGF, epidermal growth factor) and the fibrin\/coagulation cascade (thrombin, Tissue factor, plasminogen activator inhibitor [PAI]-1\/2). Chronic inflammation and cellular transformation are mediated by damage-associated molecular patterns, pattern recognition receptors, AGE-RAGE, extracellular lactate, pro-inflammatory cytokines, reactive oxygen species, increased glycolysis, metabolomic reprogramming and cancer-associated fibroblasts. The pathogenesis of EPS, EM and PM shows similarities to the cellular transformation and stromal recruitment of wound healing.<\/jats:p>","DOI":"10.1515\/pp-2018-0103","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T10:58:42Z","timestamp":1522839522000},"source":"Crossref","is-referenced-by-count":51,"title":["Hypoxia, cytokines and stromal recruitment: parallels between pathophysiology of encapsulating peritoneal sclerosis, endometriosis and peritoneal metastasis"],"prefix":"10.1515","volume":"3","author":[{"given":"Robert Beaumont","family":"Wilson","sequence":"first","affiliation":[{"name":"Upper GI Surgery Department , Liverpool Hospital, Elizabeth St , Liverpool , 2170 , NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,3,29]]},"reference":[{"key":"2026030213540710420_j_pp-2018-0103_ref_001_w2aab3b7b4b1b6b1ab1c10b1Aa","doi-asserted-by":"crossref","unstructured":"Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986;315:1650\u20139.353779110.1056\/NEJM198612253152606","DOI":"10.1056\/NEJM198612253152606"},{"key":"2026030213540710420_j_pp-2018-0103_ref_002_w2aab3b7b4b1b6b1ab1c10b2Aa","doi-asserted-by":"crossref","unstructured":"Morishita Y, Ookawara S, Hirahara I, Muto S, Nagata D. HIF-1\u03b1 mediates hypoxia-induced epithelial-mesenchymal transition in peritoneal mesothelial cells. Ren Failure 2016;38:282\u20139.10.3109\/0886022X.2015.1127741","DOI":"10.3109\/0886022X.2015.1127741"},{"key":"2026030213540710420_j_pp-2018-0103_ref_003_w2aab3b7b4b1b6b1ab1c10b3Aa","doi-asserted-by":"crossref","unstructured":"Wu MH, Chen KF, Lin SC, Lgu CW, Tsai SJ. Aberrant expression of leptin in human endometriotic stromal cells is induced by elevated levels of hypoxia inducible factor-1alpha. Am J Pathol 2007;170:590\u20138.10.2353\/ajpath.2007.06047717255327","DOI":"10.2353\/ajpath.2007.060477"},{"key":"2026030213540710420_j_pp-2018-0103_ref_004_w2aab3b7b4b1b6b1ab1c10b4Aa","doi-asserted-by":"crossref","unstructured":"Varghese S, Burness M, Xu H, Beresnev T, Pingpank J, Alexander HR. Site-specific gene expression profiles and novel molecular prognostic factors in patients with lower gastrointestinal adenocarcinoma diffusely metastatic to liver or peritoneum. Ann Surg Oncol 2007;14:3460\u201371.10.1245\/s10434-007-9557-717899288","DOI":"10.1245\/s10434-007-9557-7"},{"key":"2026030213540710420_j_pp-2018-0103_ref_005_w2aab3b7b4b1b6b1ab1c10b5Aa","unstructured":"Wagener C, Stocking C, M\u00fcller O. Cancer signaling: from molecular biology to targeted therapies. Wiley-VCH, Weinheim 2017:183\u2013204."},{"key":"2026030213540710420_j_pp-2018-0103_ref_006_w2aab3b7b4b1b6b1ab1c10b6Aa","doi-asserted-by":"crossref","unstructured":"Ceelen W, Pattyn P, Mareel M. Surgery, wound healing, and metastasis: recent insights and clinical implications. Crit Rev Oncol Hematol 2014;89:16\u201326.2395867610.1016\/j.critrevonc.2013.07.008","DOI":"10.1016\/j.critrevonc.2013.07.008"},{"key":"2026030213540710420_j_pp-2018-0103_ref_007_w2aab3b7b4b1b6b1ab1c10b7Aa","doi-asserted-by":"crossref","unstructured":"Dvorak HF. Tumors: wounds that do not heal-Redux. Cancer Immunol Res 2015;3:1\u201311.10.1158\/2326-6066.CIR-14-020925568067","DOI":"10.1158\/2326-6066.CIR-14-0209"},{"key":"2026030213540710420_j_pp-2018-0103_ref_008_w2aab3b7b4b1b6b1ab1c10b8Aa","doi-asserted-by":"crossref","unstructured":"Byun JS, Gardner K. Wounds that will not heal: pervasive cellular reprogramming in cancer. Am J Pathol 2013;182:1055\u201364.10.1016\/j.ajpath.2013.01.00923438473","DOI":"10.1016\/j.ajpath.2013.01.009"},{"key":"2026030213540710420_j_pp-2018-0103_ref_009_w2aab3b7b4b1b6b1ab1c10b9Aa","doi-asserted-by":"crossref","unstructured":"Flier JS, Underhill LH, Dvorak HF. Tumors: wounds that do not heal. N Engl J Med 1986;315:1650\u20139.353779110.1056\/NEJM198612253152606","DOI":"10.1056\/NEJM198612253152606"},{"key":"2026030213540710420_j_pp-2018-0103_ref_010_w2aab3b7b4b1b6b1ab1c10c10Aa","doi-asserted-by":"crossref","unstructured":"D\u2019Agostino A, Stellavato A, Corsuto L, Diana P, Filosa R, La Gatta A, et\u2009al. Is molecular size a discriminating factor in hyaluronan interaction with human cells? Carbohydr Polym 2017;157:21\u201330.","DOI":"10.1016\/j.carbpol.2016.07.125"},{"key":"2026030213540710420_j_pp-2018-0103_ref_011_w2aab3b7b4b1b6b1ab1c10c11Aa","doi-asserted-by":"crossref","unstructured":"Kawanishi K. Diverse properties of the mesothelial cells in health and disease. Pleura Peritoneum 2016;1:79\u201389.","DOI":"10.1515\/pp-2016-0009"},{"key":"2026030213540710420_j_pp-2018-0103_ref_012_w2aab3b7b4b1b6b1ab1c10c12Aa","doi-asserted-by":"crossref","unstructured":"Matsuzaki S, Vernis L, Bonnin M, Houlle C, Fournet-Fayard A, Rosano G, et\u2009al. Effects of low intraperitoneal pressure and a warmed, humidified carbon dioxide gas in laparoscopic surgery: a randomized clinical trial. Sci Rep 2017;7:11287.10.1038\/s41598-017-10769-1","DOI":"10.1038\/s41598-017-10769-1"},{"key":"2026030213540710420_j_pp-2018-0103_ref_013_w2aab3b7b4b1b6b1ab1c10c13Aa","doi-asserted-by":"crossref","unstructured":"Bertheloot D, Latz E. HMGB1, IL-1\u03b1, IL-33 and S100 proteins: dual-function alarmins. Cell Mol Immunol 2017;14:43\u201364.10.1038\/cmi.2016.3427569562","DOI":"10.1038\/cmi.2016.34"},{"key":"2026030213540710420_j_pp-2018-0103_ref_014_w2aab3b7b4b1b6b1ab1c10c14Aa","doi-asserted-by":"crossref","unstructured":"Tjhay F, Motohara T, Tayama S, Narantuya D, Fujimoto K, Guo J, et\u2009al. CD44 variant 6 is correlated with peritoneal dissemination and poor prognosis in patients with advanced epithelial ovarian cancer. Cancer Science 2015;106:1421\u20138.2625093410.1111\/cas.12765","DOI":"10.1111\/cas.12765"},{"key":"2026030213540710420_j_pp-2018-0103_ref_015_w2aab3b7b4b1b6b1ab1c10c15Aa","doi-asserted-by":"crossref","unstructured":"Wilson R. Changes in the coelomic microclimate during carbon dioxide laparoscopy: morphological and functional implications. Pleura Peritoneum 2017;2:17\u201331.","DOI":"10.1515\/pp-2017-0001"},{"key":"2026030213540710420_j_pp-2018-0103_ref_016_w2aab3b7b4b1b6b1ab1c10c16Aa","doi-asserted-by":"crossref","unstructured":"Misra S, Hascall VC, Markwald RR, Ghatak S. Interactions between hyaluronan and its receptors (CD44, RHAMM) regulate the activities of inflammation and cancer. Front Immunol 2015;6:201.25999946","DOI":"10.3389\/fimmu.2015.00201"},{"key":"2026030213540710420_j_pp-2018-0103_ref_017_w2aab3b7b4b1b6b1ab1c10c17Aa","doi-asserted-by":"crossref","unstructured":"Loureiro J, Sandoval P, delPeso G, G\u00f3nzalez-Mateo G, Fern\u00e1ndez-Millara V, Santamaria B, et\u2009al. Tamoxifen ameliorates peritoneal membrane damage by blocking mesothelial to mesenchymal transition in peritoneal dialysis. PLoS One 2013;23:e61165.","DOI":"10.1371\/journal.pone.0061165"},{"key":"2026030213540710420_j_pp-2018-0103_ref_018_w2aab3b7b4b1b6b1ab1c10c18Aa","doi-asserted-by":"crossref","unstructured":"Jolly MK, Ware KE, Gilja S, Somarelli JA, Levine H. EMT and MET: necessary or permissive for metastasis? Molecular Oncology 2017;11:755\u201369.2854834510.1002\/1878-0261.12083","DOI":"10.1002\/1878-0261.12083"},{"key":"2026030213540710420_j_pp-2018-0103_ref_019_w2aab3b7b4b1b6b1ab1c10c19Aa","doi-asserted-by":"crossref","unstructured":"Strippoli R, Moreno-Vicente R, Battistelli C, Cicchini C, Noce V, Amicone L, et\u2009al. Molecular mechanisms underlying peritoneal EMT and fibrosis. Stem Cells Int 2016;2016:3543678.26941801","DOI":"10.1155\/2016\/3543678"},{"key":"2026030213540710420_j_pp-2018-0103_ref_020_w2aab3b7b4b1b6b1ab1c10c20Aa","doi-asserted-by":"crossref","unstructured":"Li W, Kang Y. A new Lnc in metastasis: long non-coding RNA mediates the pro-metastatic functions of TGF-\u03b2. Cancer Cell 2014;25:557\u20139.10.1016\/j.ccr.2014.04.014","DOI":"10.1016\/j.ccr.2014.04.014"},{"key":"2026030213540710420_j_pp-2018-0103_ref_021_w2aab3b7b4b1b6b1ab1c10c21Aa","doi-asserted-by":"crossref","unstructured":"Wu Y, Tran T, Dwabe S, Sarkissyan M, Kim J, Nava M, et\u2009al. A83-01 inhibits TGF-\u03b2-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells. Breast Cancer Res Treat 2017;163:449\u201360.10.1007\/s10549-017-4211-y28337662","DOI":"10.1007\/s10549-017-4211-y"},{"key":"2026030213540710420_j_pp-2018-0103_ref_022_w2aab3b7b4b1b6b1ab1c10c22Aa","doi-asserted-by":"crossref","unstructured":"Xu F, Liu C, Zhou D, Zhang L. TGF-\u03b2\/SMAD pathway and its regulation in hepatic fibrosis. J Histochem Cytochem 2016;64:157\u201367.10.1369\/002215541562768126747705","DOI":"10.1369\/0022155415627681"},{"key":"2026030213540710420_j_pp-2018-0103_ref_023_w2aab3b7b4b1b6b1ab1c10c23Aa","doi-asserted-by":"crossref","unstructured":"Govinden R, Bhoola KD. Genealogy, expression, and cellular function of transforming growth factor-beta. Pharmacol Ther 2003;98:257\u201365.1272587310.1016\/S0163-7258(03)00035-4","DOI":"10.1016\/S0163-7258(03)00035-4"},{"key":"2026030213540710420_j_pp-2018-0103_ref_024_w2aab3b7b4b1b6b1ab1c10c24Aa","doi-asserted-by":"crossref","unstructured":"Jin X, Ren S, Macarak E, Rosenbloom J. Pathobiological mechanisms of peritoneal adhesions: the mesenchymal transition of rat peritoneal mesothelial cells induced by TGF-\u03b21 and IL-6 requires activation of Erk1\/2 and SMAD2 linker region phosphorylation. Matrix Biol 2016;51:55\u201364.2682531710.1016\/j.matbio.2016.01.017","DOI":"10.1016\/j.matbio.2016.01.017"},{"key":"2026030213540710420_j_pp-2018-0103_ref_025_w2aab3b7b4b1b6b1ab1c10c25Aa","doi-asserted-by":"crossref","unstructured":"Falk P, Angenete E, Bergstr\u00f6m M, Ivarsson ML. TGF-beta1 promotes transition of mesothelial cells into fibroblast phenotype in response to peritoneal injury in a cell culture model. Int J Surg 2013;11:977\u201382.10.1016\/j.ijsu.2013.06.005","DOI":"10.1016\/j.ijsu.2013.06.005"},{"key":"2026030213540710420_j_pp-2018-0103_ref_026_w2aab3b7b4b1b6b1ab1c10c26Aa","doi-asserted-by":"crossref","unstructured":"Liappas G, Gonz\u00e1lez-Mateo GT, S\u00e1nchez-D\u00edaz R, Lazcano JJ, Lasarte S, Matesanz-Mar\u00edn A, et\u2009al. Immune-regulatory molecule CD69 controls peritoneal fibrosis. J Am Soc Nephrol 2016;27:3561\u201376.2715191910.1681\/ASN.2015080909","DOI":"10.1681\/ASN.2015080909"},{"key":"2026030213540710420_j_pp-2018-0103_ref_027_w2aab3b7b4b1b6b1ab1c10c27Aa","doi-asserted-by":"crossref","unstructured":"Corcoran SE, O\u2019Neill LA. HIF-1\u03b1 and metabolic reprogramming in inflammation. J Clin Invest 2016;126:3699\u2013707.10.1172\/JCI8443127571407","DOI":"10.1172\/JCI84431"},{"key":"2026030213540710420_j_pp-2018-0103_ref_028_w2aab3b7b4b1b6b1ab1c10c28Aa","doi-asserted-by":"crossref","unstructured":"Trendelenburg AU, Meyer A, Jacobi C, Feige JN, Glass DJ. TAK-1\/p38\/nNF\u03baB signaling inhibits myoblast differentiation by increasing levels of Activin A. Skeletal Muscle 2012;2:3.10.1186\/2044-5040-2-322313861","DOI":"10.1186\/2044-5040-2-3"},{"key":"2026030213540710420_j_pp-2018-0103_ref_029_w2aab3b7b4b1b6b1ab1c10c29Aa","doi-asserted-by":"crossref","unstructured":"Midgley AC, Rogers M, Hallett MB, Clayton A, Bowen T, Phillips AO, et\u2009al. Transforming growth factor-\u03b21 (TGF-\u03b21)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. J Biol Chem 2013;288:14824\u201338.10.1074\/jbc.M113.45133623589287","DOI":"10.1074\/jbc.M113.451336"},{"key":"2026030213540710420_j_pp-2018-0103_ref_030_w2aab3b7b4b1b6b1ab1c10c30Aa","doi-asserted-by":"crossref","unstructured":"Pohlers D, Brenmoehl J, L\u00f6ffler I, M\u00fcller CK, Leipner C, Schultze-Mosgau S, et\u2009al. TGF-beta and fibrosis in different organs \u2013 molecular pathway imprints. Biochim Biophys Acta 2009;1792:746\u201356.10.1016\/j.bbadis.2009.06.00419539753","DOI":"10.1016\/j.bbadis.2009.06.004"},{"key":"2026030213540710420_j_pp-2018-0103_ref_031_w2aab3b7b4b1b6b1ab1c10c31Aa","doi-asserted-by":"crossref","unstructured":"Zarzynska JM. Two faces of TGF-beta1 in breast cancer. Mediators Inflamm 2014;2014:141747.24891760","DOI":"10.1155\/2014\/141747"},{"key":"2026030213540710420_j_pp-2018-0103_ref_032_w2aab3b7b4b1b6b1ab1c10c32Aa","doi-asserted-by":"crossref","unstructured":"Li YS, Ni SY, Meng Y, Shi XL, Zhao XW, Luo HH, et\u2009al. Angiotensin II facilitates fibrogenic effect of TGF-\u03b21 through enhancing the down-regulation of BAMBI caused by LPS: a new pro-fibrotic mechanism of angiotensin II. Chen Y Ed PLoS One 2013;8:e76289.10.1371\/journal.pone.0076289","DOI":"10.1371\/journal.pone.0076289"},{"key":"2026030213540710420_j_pp-2018-0103_ref_033_w2aab3b7b4b1b6b1ab1c10c33Aa","doi-asserted-by":"crossref","unstructured":"Alexander ET, Minton AR, Peters MC, van Ryn J, Gilmour SK. Thrombin inhibition and cisplatin block tumor progression in ovarian cancer by alleviating the immunosuppressive microenvironment. Oncotarget 2016;7:85291\u2013305.27852034","DOI":"10.18632\/oncotarget.13300"},{"key":"2026030213540710420_j_pp-2018-0103_ref_034_w2aab3b7b4b1b6b1ab1c10c34Aa","doi-asserted-by":"crossref","unstructured":"Andrarawewa KL, Kirshner J, Mott JD, Barcellos-Hoff MH. TGF \u03b2: roles in DNA responses. Cancer treatment and therapy. In: Jakowlew SB, editor. From transforming growth factor \u03b2 in cancer therapy (Vol. II). New York: Human Press, 2010:321\u201331.","DOI":"10.1007\/978-1-59745-293-9_21"},{"key":"2026030213540710420_j_pp-2018-0103_ref_035_w2aab3b7b4b1b6b1ab1c10c35Aa","doi-asserted-by":"crossref","unstructured":"Richter K, Kietzmann T. Reactive oxygen species and fibrosis: further evidence of a significant liaison. Cell Tissue Res 2016;365:591\u2013605.2734530110.1007\/s00441-016-2445-3","DOI":"10.1007\/s00441-016-2445-3"},{"key":"2026030213540710420_j_pp-2018-0103_ref_036_w2aab3b7b4b1b6b1ab1c10c36Aa","doi-asserted-by":"crossref","unstructured":"Lebrun JJ. The dual role of TGF-\u03b2 in human cancer: from tumor suppression to cancer metastasis. ISRN Mol Biol 2012;381428:1\u201328.","DOI":"10.5402\/2012\/381428"},{"key":"2026030213540710420_j_pp-2018-0103_ref_037_w2aab3b7b4b1b6b1ab1c10c37Aa","doi-asserted-by":"crossref","unstructured":"Moustakas A, Heldin CH. The regulation of TGF\u03b2 signal transduction. Development 2009;136:3699\u2013714.10.1242\/dev.03033819855013","DOI":"10.1242\/dev.030338"},{"key":"2026030213540710420_j_pp-2018-0103_ref_038_w2aab3b7b4b1b6b1ab1c10c38Aa","doi-asserted-by":"crossref","unstructured":"Otten J, Bokemeyer C, Fiedler W. TGF-beta superfamily receptors-targets for antiangiogenic therapy? J Oncol 2010:317068.20490264","DOI":"10.1155\/2010\/317068"},{"key":"2026030213540710420_j_pp-2018-0103_ref_039_w2aab3b7b4b1b6b1ab1c10c39Aa","doi-asserted-by":"crossref","unstructured":"Alsina-Sanch\u00eds E, Figueras A, Lahiguera A, Gil-Mart\u00edn M, Pardo B, Piulats JM, et\u2009al. TGF\u03b2 controls ovarian cancer cell proliferation. Int J Mol Sci 2017;18:1658.28758950","DOI":"10.3390\/ijms18081658"},{"key":"2026030213540710420_j_pp-2018-0103_ref_040_w2aab3b7b4b1b6b1ab1c10c40Aa","doi-asserted-by":"crossref","unstructured":"Gupta DK, Singh N, Sahu DK. TGF-\u03b2 mediated crosstalk between malignant hepatocyte and tumor microenvironment in hepatocellular carcinoma. Cancer Growth Metastasis 2014;7:1\u20138.24741325","DOI":"10.4137\/CGM.S14205"},{"key":"2026030213540710420_j_pp-2018-0103_ref_041_w2aab3b7b4b1b6b1ab1c10c41Aa","doi-asserted-by":"crossref","unstructured":"Chru\u015bcik A, Gopalan V, Lam AK. The clinical and biological roles of transforming growth factor beta in colon cancer stem cells: a systematic review. Eur J Cell Biol 2018;97:15\u201322.10.1016\/j.ejcb.2017.11.00129128131","DOI":"10.1016\/j.ejcb.2017.11.001"},{"key":"2026030213540710420_j_pp-2018-0103_ref_042_w2aab3b7b4b1b6b1ab1c10c42Aa","doi-asserted-by":"crossref","unstructured":"Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D, Shevach EM. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Proc Natl Acad Sci USA 2009;106:13445\u201350.10.1073\/pnas.0901944106","DOI":"10.1073\/pnas.0901944106"},{"key":"2026030213540710420_j_pp-2018-0103_ref_043_w2aab3b7b4b1b6b1ab1c10c43Aa","doi-asserted-by":"crossref","unstructured":"Eser P\u00d6, J\u00e4nne PA. TGF\u03b2 pathway inhibition in the treatment of non-small cell lung cancer. Pharmacol Ther 2017. pii: S0163-7258(17)30288-7. DOI:10.1016\/j.pharmthera.2017.11.004. [Epub ahead of print].29129643","DOI":"10.1016\/j.pharmthera.2017.11.004"},{"key":"2026030213540710420_j_pp-2018-0103_ref_044_w2aab3b7b4b1b6b1ab1c10c44Aa","doi-asserted-by":"crossref","unstructured":"Staudacher JJ, Bauer J, Jana A, Tian J, Carroll T, Mancinelli G, et\u2009al. Activin signaling is an essential component of the TGF-\u03b2 induced pro-metastatic phenotype in colorectal cancer. Sci Rep 2017;7:5569.10.1038\/s41598-017-05907-828717230","DOI":"10.1038\/s41598-017-05907-8"},{"key":"2026030213540710420_j_pp-2018-0103_ref_045_w2aab3b7b4b1b6b1ab1c10c45Aa","doi-asserted-by":"crossref","unstructured":"Hata A, Chen YG TGF-beta signaling from receptors to Smads. Cold Spring Harb 2016 Perspect Biol 8:a022061.","DOI":"10.1101\/cshperspect.a022061"},{"key":"2026030213540710420_j_pp-2018-0103_ref_046_w2aab3b7b4b1b6b1ab1c10c46Aa","doi-asserted-by":"crossref","unstructured":"Young VJ, Ahmad SF, Duncan WC, Horne AW. The role of TGF-\u03b2 in the pathophysiology of peritoneal endometriosis. Hum Reprod Update 2017;23:548\u201359.10.1093\/humupd\/dmx01628903471","DOI":"10.1093\/humupd\/dmx016"},{"key":"2026030213540710420_j_pp-2018-0103_ref_047_w2aab3b7b4b1b6b1ab1c10c47Aa","doi-asserted-by":"crossref","unstructured":"Yan X, Liao H, Cheng M, Shi X, Lin X, Feng XH, et\u2009al. Smad7 protein interacts with Receptor-regulated Smads (R-Smads) to inhibit Transforming Growth Factor-\u03b2 (TGF-\u03b2)\/Smad Signaling. J Biol Chem 2016;291:382\u201392.10.1074\/jbc.M115.69428126555259","DOI":"10.1074\/jbc.M115.694281"},{"key":"2026030213540710420_j_pp-2018-0103_ref_048_w2aab3b7b4b1b6b1ab1c10c48Aa","doi-asserted-by":"crossref","unstructured":"Zhang J, Zhang X, Xie F, Zhang Z, van Dam H, Zhang L, et\u2009al. The regulation of TGF-\u03b2\/SMAD signaling by protein deubiquitination. Protein Cell 2014;5:503\u201317.10.1007\/s13238-014-0058-824756567","DOI":"10.1007\/s13238-014-0058-8"},{"key":"2026030213540710420_j_pp-2018-0103_ref_049_w2aab3b7b4b1b6b1ab1c10c49Aa","doi-asserted-by":"crossref","unstructured":"Xiao L, Peng X, Liu F, Tang C, Hu C, Xu X, et\u2009al. AKT regulation of mesothelial-to-mesenchymal transition in peritoneal dialysis is modulated by Smurf2 and deubiquitinating enzyme USP4. BMC Cell Biol 2015;16:7.2588590410.1186\/s12860-015-0055-7","DOI":"10.1186\/s12860-015-0055-7"},{"key":"2026030213540710420_j_pp-2018-0103_ref_050_w2aab3b7b4b1b6b1ab1c10c50Aa","doi-asserted-by":"crossref","unstructured":"Meng XM, Tang PM, Li J, Lan HY. TGF-\u03b2\/Smad signaling in renal fibrosis. Front Physiol 2015;6:82.25852569","DOI":"10.3389\/fphys.2015.00082"},{"key":"2026030213540710420_j_pp-2018-0103_ref_051_w2aab3b7b4b1b6b1ab1c10c51Aa","doi-asserted-by":"crossref","unstructured":"Guo H, Leung JC, Lam MF, Chan LY, Tsang AW, Lan HY, et\u2009al. Smad7 transgene attenuates peritoneal fibrosis in uremic rats treated with peritoneal dialysis. J Am Soc Nephrol 2007;18:2689\u2013703.10.1681\/ASN.200701012117855642","DOI":"10.1681\/ASN.2007010121"},{"key":"2026030213540710420_j_pp-2018-0103_ref_052_w2aab3b7b4b1b6b1ab1c10c52Aa","doi-asserted-by":"crossref","unstructured":"Basu M, Bhattacharya R, Ray U, Mukhopadhyay S, Chatterjee U, Roy SS. Invasion of ovarian cancer cells is induced by PITX2-mediated activation of TGF-beta and Activin-A. Mol Cancer 2015;14:162.10.1186\/s12943-015-0433-y26298390","DOI":"10.1186\/s12943-015-0433-y"},{"key":"2026030213540710420_j_pp-2018-0103_ref_053_w2aab3b7b4b1b6b1ab1c10c53Aa","doi-asserted-by":"crossref","unstructured":"Lee YH, Schiemann WP. Chemotherapeutic targeting of the transforming growth factor-\u03b2 pathway in breast cancers. Breast Cancer Manage 2014;3:73\u201385.10.2217\/bmt.13.74","DOI":"10.2217\/bmt.13.74"},{"key":"2026030213540710420_j_pp-2018-0103_ref_054_w2aab3b7b4b1b6b1ab1c10c54Aa","doi-asserted-by":"crossref","unstructured":"Zhou J, Schmid T, Frank R, Br\u00fcne B. PI3K\/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. J Biol Chem 2004;279:13506\u201313.10.1074\/jbc.M31016420014726529","DOI":"10.1074\/jbc.M310164200"},{"key":"2026030213540710420_j_pp-2018-0103_ref_055_w2aab3b7b4b1b6b1ab1c10c55Aa","doi-asserted-by":"crossref","unstructured":"Ren K, Mo ZC, Liu X, Tang ZL, Jiang Y, Peng XS, et\u2009al. TGF-beta down-regulates apolipoprotein M expression through the TAK-1-JNK-c-Jun pathway in HepG2 Cells. Lipids 2017;52:109\u201317.2803958710.1007\/s11745-016-4227-9","DOI":"10.1007\/s11745-016-4227-9"},{"key":"2026030213540710420_j_pp-2018-0103_ref_056_w2aab3b7b4b1b6b1ab1c10c56Aa","doi-asserted-by":"crossref","unstructured":"Zhang S, Che D, Yang F, Chi C, Meng H, Shen J, et\u2009al. Tumor-associated macrophages promote tumor metastasis via the TGF-\u03b2\/SOX9 axis in non-small cell lung cancer. Oncotarget 2017;8:99801\u201315.29245941","DOI":"10.18632\/oncotarget.21068"},{"key":"2026030213540710420_j_pp-2018-0103_ref_057_w2aab3b7b4b1b6b1ab1c10c57Aa","doi-asserted-by":"crossref","unstructured":"Zhang YE. Mechanistic insight into contextual TGF-\u03b2 signaling. Curr Opin Cell Biol 2017;51:1\u20137. DOI:10.1016\/j.ceb.2017.10.001.29149681","DOI":"10.1016\/j.ceb.2017.10.001"},{"key":"2026030213540710420_j_pp-2018-0103_ref_058_w2aab3b7b4b1b6b1ab1c10c58Aa","doi-asserted-by":"crossref","unstructured":"Bartscht T, Rosien B, Rades D, Kaufmann R, Biersack H, Lehnert H, et\u2009al. Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action. Mol Cancer 2015;14:199.10.1186\/s12943-015-0468-026588899","DOI":"10.1186\/s12943-015-0468-0"},{"key":"2026030213540710420_j_pp-2018-0103_ref_059_w2aab3b7b4b1b6b1ab1c10c59Aa","doi-asserted-by":"crossref","unstructured":"Rahman MS, Akhtar N, Jamil HM, Banik RS, Asaduzzaman SM. TGF-\u03b2\/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation. Bone Res 2015;3:15005.10.1038\/boneres.2015.526273537","DOI":"10.1038\/boneres.2015.5"},{"key":"2026030213540710420_j_pp-2018-0103_ref_060_w2aab3b7b4b1b6b1ab1c10c60Aa","doi-asserted-by":"crossref","unstructured":"Serrano I, McDonald PC, Lock FE, Dedhar S. Role of the integrin-linked kinase (ILK)\/Rictor complex in TGF beta-1-induced epithelial-mesenchymal transition (EMT). Oncogene 2013;32:50\u201360.10.1038\/onc.2012.30","DOI":"10.1038\/onc.2012.30"},{"key":"2026030213540710420_j_pp-2018-0103_ref_061_w2aab3b7b4b1b6b1ab1c10c61Aa","doi-asserted-by":"crossref","unstructured":"Ahamed J, Laurence J. Role of platelet-derived transforming growth factor-\u03b21 and reactive oxygen species in radiation-induced organ fibrosis. Antioxid Redox Signal 2017;27:977\u201388.10.1089\/ars.2017.706428562065","DOI":"10.1089\/ars.2017.7064"},{"key":"2026030213540710420_j_pp-2018-0103_ref_062_w2aab3b7b4b1b6b1ab1c10c62Aa","doi-asserted-by":"crossref","unstructured":"Davi G, Ciabattoni G, Consoli A, Mezzetti A, Falco A, Santarone S, et\u2009al. In vivo formation of 8-iso-prostaglandin F2\u03b1 and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation 1999;99:224\u20139.10.1161\/01.CIR.99.2.2249892587","DOI":"10.1161\/01.CIR.99.2.224"},{"key":"2026030213540710420_j_pp-2018-0103_ref_063_w2aab3b7b4b1b6b1ab1c10c63Aa","doi-asserted-by":"crossref","unstructured":"Souza AM, Wang CC, Chu CY, Lam PM, Rogers MS. The effect of intra-abdominal pressure on the generation of 8-iso prostaglandin F2 during laparoscopy in rabbits. Hum Reprod 2003;18:2181\u20138.1450784210.1093\/humrep\/deg405","DOI":"10.1093\/humrep\/deg405"},{"key":"2026030213540710420_j_pp-2018-0103_ref_064_w2aab3b7b4b1b6b1ab1c10c64Aa","doi-asserted-by":"crossref","unstructured":"Terawaki H, Hayashi Y, Zhu WJ, Matsuyama Y, Terada T, Kabayama S, et\u2009al. Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity. Med Gas Res 2013;3:14.2381623910.1186\/2045-9912-3-14","DOI":"10.1186\/2045-9912-3-14"},{"key":"2026030213540710420_j_pp-2018-0103_ref_065_w2aab3b7b4b1b6b1ab1c10c65Aa","doi-asserted-by":"crossref","unstructured":"Takemoto A, Okitaka M, Takagi S, Takami M, Sato S, Nishio M, et\u2009al. A critical role of platelet TGF-\u03b2 release in podoplanin-mediated tumour invasion and metastasis. Sci Rep 2017;7:42186.2817685210.1038\/srep42186","DOI":"10.1038\/srep42186"},{"key":"2026030213540710420_j_pp-2018-0103_ref_066_w2aab3b7b4b1b6b1ab1c10c66Aa","doi-asserted-by":"crossref","unstructured":"Schofield CJ, Ratcliffe PJ. Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 2004;5:343\u201354.1512234810.1038\/nrm1366","DOI":"10.1038\/nrm1366"},{"key":"2026030213540710420_j_pp-2018-0103_ref_067_w2aab3b7b4b1b6b1ab1c10c67Aa","doi-asserted-by":"crossref","unstructured":"Karuppagounder SS, Ratan RR. Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics? J Cereb Blood Flow Metab 2012;32:1347\u201361.2241552510.1038\/jcbfm.2012.28","DOI":"10.1038\/jcbfm.2012.28"},{"key":"2026030213540710420_j_pp-2018-0103_ref_068_w2aab3b7b4b1b6b1ab1c10c68Aa","doi-asserted-by":"crossref","unstructured":"Haase VH. HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism. Hemodialysis Int 2017;21:S110\u2013S24.","DOI":"10.1111\/hdi.12567"},{"key":"2026030213540710420_j_pp-2018-0103_ref_069_w2aab3b7b4b1b6b1ab1c10c69Aa","doi-asserted-by":"crossref","unstructured":"Lamichhane SP, Arya N, Kohler E, Xiang S, Christensen J, Shastri VP. Recapitulating epithelial tumor microenvironment in vitro using three dimensional tri-culture of human epithelial, endothelial, and mesenchymal cells. BMC Cancer 2016;16:581.2748499310.1186\/s12885-016-2634-1","DOI":"10.1186\/s12885-016-2634-1"},{"key":"2026030213540710420_j_pp-2018-0103_ref_070_w2aab3b7b4b1b6b1ab1c10c70Aa","doi-asserted-by":"crossref","unstructured":"Slemc L, Kunej T. Transcription factor HIF1A: downstream targets, associated pathways, polymorphic hypoxia response element (HRE) sites, and initiative for standardization of reporting in scientific literature. Tumour Biol 2016;37:14851\u201361.10.1007\/s13277-016-5331-427644243","DOI":"10.1007\/s13277-016-5331-4"},{"key":"2026030213540710420_j_pp-2018-0103_ref_071_w2aab3b7b4b1b6b1ab1c10c71Aa","doi-asserted-by":"crossref","unstructured":"Huang R, Zong X. Aberrant cancer metabolism in epithelial\u2013mesenchymal transition and cancer metastasis: mechanisms in cancer progression. Crit Rev Oncol Hematol 2017;115:13\u201322.2860216510.1016\/j.critrevonc.2017.04.005","DOI":"10.1016\/j.critrevonc.2017.04.005"},{"key":"2026030213540710420_j_pp-2018-0103_ref_072_w2aab3b7b4b1b6b1ab1c10c72Aa","doi-asserted-by":"crossref","unstructured":"Clem BF, Chesney J. Molecular pathways: regulation of metabolism by RB. Clin Cancer Res 2012;18:6096\u2013100.10.1158\/1078-0432.CCR-11-316423154086","DOI":"10.1158\/1078-0432.CCR-11-3164"},{"key":"2026030213540710420_j_pp-2018-0103_ref_073_w2aab3b7b4b1b6b1ab1c10c73Aa","doi-asserted-by":"crossref","unstructured":"Lee G, Won HS, Lee YM, Choi JW, Oh TI, Jang JH, et\u2009al. Oxidative dimerization of PHD2 is responsible for its inactivation and contributes to metabolic reprogramming via HIF-1\u03b1 activation. Sci Rep 2016;6:18928.10.1038\/srep1892826740011","DOI":"10.1038\/srep18928"},{"key":"2026030213540710420_j_pp-2018-0103_ref_074_w2aab3b7b4b1b6b1ab1c10c74Aa","doi-asserted-by":"crossref","unstructured":"Wei L, Li K, Pang X, Guo B, Su M, Huang Y, et\u2009al. Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2. J Exp Clin Cancer Res 2016;35:166.10.1186\/s13046-016-0446-427769315","DOI":"10.1186\/s13046-016-0446-4"},{"key":"2026030213540710420_j_pp-2018-0103_ref_075_w2aab3b7b4b1b6b1ab1c10c75Aa","doi-asserted-by":"crossref","unstructured":"Young VJ, Brown JK, Maybin J, Saunders PT, Duncan WC, Horne AW. Transforming growth factor-\u03b2 induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis. J Clin Endocrinol Metab 2014;99:3450\u20139.10.1210\/jc.2014-102624796928","DOI":"10.1210\/jc.2014-1026"},{"key":"2026030213540710420_j_pp-2018-0103_ref_076_w2aab3b7b4b1b6b1ab1c10c76Aa","doi-asserted-by":"crossref","unstructured":"Nass N, Br\u00f6mme HJ, Hartig R, Korkmaz S, Sel S, Hirche F, et\u2009al. Differential response to \u03b1-oxoaldehydes in tamoxifen resistant MCF-7 breast cancer cells. PLoS One 2014;9:e101473.10.1371\/journal.pone.010147324983248","DOI":"10.1371\/journal.pone.0101473"},{"key":"2026030213540710420_j_pp-2018-0103_ref_077_w2aab3b7b4b1b6b1ab1c10c77Aa","doi-asserted-by":"crossref","unstructured":"Fu QF, Liu Y, Fan Y, Hua SN, Qu HY, Dong SW, et\u2009al. Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K\/AKT pathway. J Hematol Oncol 2015;8:22.2588776010.1186\/s13045-015-0117-5","DOI":"10.1186\/s13045-015-0117-5"},{"key":"2026030213540710420_j_pp-2018-0103_ref_078_w2aab3b7b4b1b6b1ab1c10c78Aa","doi-asserted-by":"crossref","unstructured":"Sun L, Guo C, Cao J, Burnett J, Yang Z, Ran Y, et\u2009al. Over-expression of alpha-enolase as a prognostic biomarker in patients with pancreatic cancer. Int J Med Sci 2017;14:655\u201361.2882429710.7150\/ijms.18736","DOI":"10.7150\/ijms.18736"},{"key":"2026030213540710420_j_pp-2018-0103_ref_079_w2aab3b7b4b1b6b1ab1c10c79Aa","doi-asserted-by":"crossref","unstructured":"Gao X, Wang H, Jenny JY, Liu X, Liu ZR. Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Mol Cell 2012;45:598\u2013609.2230629310.1016\/j.molcel.2012.01.001","DOI":"10.1016\/j.molcel.2012.01.001"},{"key":"2026030213540710420_j_pp-2018-0103_ref_080_w2aab3b7b4b1b6b1ab1c10c80Aa","doi-asserted-by":"crossref","unstructured":"He X, Du S, Lei T, Li X, Liu Y, Wang H, et\u2009al. PKM2 in carcinogenesis and oncotherapy. Oncotarget 2017;8:110656\u201370.29299177","DOI":"10.18632\/oncotarget.22529"},{"key":"2026030213540710420_j_pp-2018-0103_ref_081_w2aab3b7b4b1b6b1ab1c10c81Aa","doi-asserted-by":"crossref","unstructured":"Luo W, Hu H, Chang R, Zhong J, Knabel M, O\u2019Meally R, et\u2009al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011;145:732\u201344.2162013810.1016\/j.cell.2011.03.054","DOI":"10.1016\/j.cell.2011.03.054"},{"key":"2026030213540710420_j_pp-2018-0103_ref_082_w2aab3b7b4b1b6b1ab1c10c82Aa","doi-asserted-by":"crossref","unstructured":"Basu RK, Hubchak S, Hayashida T, Runyan CE, Schumacker PT, Schnaper HW. Interdependence of HIF-1\u03b1 and TGF-\u03b2\/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression. Am J Physiol Renal Physiol 2011;300:F898\u2013905.10.1152\/ajprenal.00335.201021209004","DOI":"10.1152\/ajprenal.00335.2010"},{"key":"2026030213540710420_j_pp-2018-0103_ref_083_w2aab3b7b4b1b6b1ab1c10c83Aa","doi-asserted-by":"crossref","unstructured":"Liu M, Ning X, Li R, Yang Z, Yang X, Sun S, et\u2009al. Signalling pathways involved in hypoxia-induced renal fibrosis. J Cell Mol Med 2017;21:1248\u201359.2809782510.1111\/jcmm.13060","DOI":"10.1111\/jcmm.13060"},{"key":"2026030213540710420_j_pp-2018-0103_ref_084_w2aab3b7b4b1b6b1ab1c10c84Aa","doi-asserted-by":"crossref","unstructured":"Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, et\u2009al. Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. J Biol Chem 2007;282:37064\u201373.1796502410.1074\/jbc.M705015200","DOI":"10.1074\/jbc.M705015200"},{"key":"2026030213540710420_j_pp-2018-0103_ref_085_w2aab3b7b4b1b6b1ab1c10c85Aa","doi-asserted-by":"crossref","unstructured":"Sekiguchi Y, Zhang J, Patterson S, Liu L, Hamada C, Tomino Y, et\u2009al. Rapamycin inhibits transforming growth factor \u03b2-induced peritoneal angiogenesis by blocking the secondary hypoxic response. J Cell Mol Med 2012;16:1934\u201345.10.1111\/j.1582-4934.2011.01493.x22117756","DOI":"10.1111\/j.1582-4934.2011.01493.x"},{"key":"2026030213540710420_j_pp-2018-0103_ref_086_w2aab3b7b4b1b6b1ab1c10c86Aa","doi-asserted-by":"crossref","unstructured":"Kawaguchi Y, Saito A, Kawanishi H, Nakayama M, Miyazaki M, Nakamoto H, et\u2009al. Recommendations on the management of encapsulating peritoneal sclerosis in Japan, 2005: diagnosis, predictive markers, treatment, and preventive measures. Perit Dial Int 2005;25:S83\u2013S95.","DOI":"10.1177\/089686080502504S12"},{"key":"2026030213540710420_j_pp-2018-0103_ref_087_w2aab3b7b4b1b6b1ab1c10c87Aa","doi-asserted-by":"crossref","unstructured":"Oran E, Seyit H, Besleyici C, \u00dcnsal A, Al\u0131s H. Encapsulating peritoneal sclerosis as a late complication of peritoneal dialysis. Ann Med Surg 2015;4:205\u20137.10.1016\/j.amsu.2015.03.006","DOI":"10.1016\/j.amsu.2015.03.006"},{"key":"2026030213540710420_j_pp-2018-0103_ref_088_w2aab3b7b4b1b6b1ab1c10c88Aa","doi-asserted-by":"crossref","unstructured":"Kawanishi H. Surgical and medical treatments of encapsulation peritoneal sclerosis. Contrib Nephrol 2012;177:38\u201347.10.1159\/00033693422613913","DOI":"10.1159\/000336934"},{"key":"2026030213540710420_j_pp-2018-0103_ref_089_w2aab3b7b4b1b6b1ab1c10c89Aa","doi-asserted-by":"crossref","unstructured":"Kawanishi K, Honda K, Hamada C. Recommendations for pathological diagnosis on biopsy samples from peritoneal dialysis patients. Pleura Peritoneum 2017;2:3\u201315.","DOI":"10.1515\/pp-2016-0028"},{"key":"2026030213540710420_j_pp-2018-0103_ref_090_w2aab3b7b4b1b6b1ab1c10c90Aa","doi-asserted-by":"crossref","unstructured":"Braun N, Fritz P, Ulmer C, Latus J, Kimmel M, Biegger D, et\u2009al. Histological criteria for encapsulating peritoneal sclerosis \u2013 a standardized approach. PLoS One 2012;7:e48647.2314491710.1371\/journal.pone.0048647","DOI":"10.1371\/journal.pone.0048647"},{"key":"2026030213540710420_j_pp-2018-0103_ref_091_w2aab3b7b4b1b6b1ab1c10c91Aa","doi-asserted-by":"crossref","unstructured":"Moinuddin Z, Summers A, Van Dellen D, Augustine T, Herrick SE. Encapsulating peritoneal sclerosis \u2013 a rare but devastating peritoneal disease. Front Physiol 2014;5:470.25601836","DOI":"10.3389\/fphys.2014.00470"},{"key":"2026030213540710420_j_pp-2018-0103_ref_092_w2aab3b7b4b1b6b1ab1c10c92Aa","doi-asserted-by":"crossref","unstructured":"Brown EA, Bargman J, van Biesen W, Chang MY, Finkelstein FO, Hurst H, et\u2009al. Length of time on peritoneal dialysis and encapsulating peritoneal sclerosis \u2013 position paper for ISPD: 2017 update. Perit Dial Int 2017;37:362\u201374.10.3747\/pdi.2017.0001828676507","DOI":"10.3747\/pdi.2017.00018"},{"key":"2026030213540710420_j_pp-2018-0103_ref_093_w2aab3b7b4b1b6b1ab1c10c93Aa","doi-asserted-by":"crossref","unstructured":"Rigby RJ, Hawley CM. Sclerosing peritonitis: the experience in Australia. Nephrol Dial Transplant 1998;13:154\u20139.948173210.1093\/ndt\/13.1.154","DOI":"10.1093\/ndt\/13.1.154"},{"key":"2026030213540710420_j_pp-2018-0103_ref_094_w2aab3b7b4b1b6b1ab1c10c94Aa","doi-asserted-by":"crossref","unstructured":"Brown MC, Simpson K, Kerssens JJ, Mactier R. Encapsulating peritoneal sclerosis in the new millennium: a national cohort study. Clin J Am Soc Nephrol 2009;4:1222\u20139.1954181510.2215\/CJN.01260209","DOI":"10.2215\/CJN.01260209"},{"key":"2026030213540710420_j_pp-2018-0103_ref_095_w2aab3b7b4b1b6b1ab1c10c95Aa","doi-asserted-by":"crossref","unstructured":"Cornelis T, Oreopoulos DG. Update on potential medical treatments for encapsulating peritoneal sclerosis; human and experimental data. Int Urol Nephrol 2011;43:147\u201356.10.1007\/s11255-010-9744-520449655","DOI":"10.1007\/s11255-010-9744-5"},{"key":"2026030213540710420_j_pp-2018-0103_ref_096_w2aab3b7b4b1b6b1ab1c10c96Aa","doi-asserted-by":"crossref","unstructured":"Mortier S, DeVriese AS, VandeVoorde J, Schaub TP, Passlick-Deetjen J, Lameire NH. Hemodynamic effects of peritoneal dialysis solutions on the rat peritoneal membrane: role of acidity, buffer choice, glucose concentration, and glucose degradation products. J Am Soc Nephrol 2002;13:480\u20139.11805178","DOI":"10.1681\/ASN.V132480"},{"key":"2026030213540710420_j_pp-2018-0103_ref_097_w2aab3b7b4b1b6b1ab1c10c97Aa","doi-asserted-by":"crossref","unstructured":"Lin L, Park S, Lakatta EG. RAGE signaling in inflammation and arterial aging. Front Biosci (Landmark Ed). 2009;14:1403\u201313.19273137","DOI":"10.2741\/3315"},{"key":"2026030213540710420_j_pp-2018-0103_ref_098_w2aab3b7b4b1b6b1ab1c10c98Aa","doi-asserted-by":"crossref","unstructured":"Byun K, Yoo Y, Son M, Lee J, Jeong GB, Park YM, et\u2009al. Advanced glycation end-products produced systemically and by macrophages: a common contributor to inflammation and degenerative diseases. Pharmacol Ther 2017;177:44\u201355.2822323410.1016\/j.pharmthera.2017.02.030","DOI":"10.1016\/j.pharmthera.2017.02.030"},{"key":"2026030213540710420_j_pp-2018-0103_ref_099_w2aab3b7b4b1b6b1ab1c10c99Aa","doi-asserted-by":"crossref","unstructured":"Paudel K, Fan SL. Is there an end in sight for encapsulating peritoneal sclerosis? Perit Dial Int 2014;34:576\u20138.10.3747\/pdi.2014.0008725228209","DOI":"10.3747\/pdi.2014.00087"},{"key":"2026030213540710420_j_pp-2018-0103_ref_100_w2aab3b7b4b1b6b1ab1c10d100Aa","doi-asserted-by":"crossref","unstructured":"Lin F, Wu X, Zhang H, You X, Zhang Z, Shao R, et\u2009al. A microrna screen to identify regulators of peritoneal fibrosis in a rat model of peritoneal dialysis. BMC Nephrol 2015;16:48.10.1186\/s12882-015-0039-z","DOI":"10.1186\/s12882-015-0039-z"},{"key":"2026030213540710420_j_pp-2018-0103_ref_101_w2aab3b7b4b1b6b1ab1c10d101Aa","doi-asserted-by":"crossref","unstructured":"De Sousa-Amorim E, Del Peso G, Bajo MA, Alvarez L, Ossorio M, Gil F, et\u2009al. Can EPS development be avoided with early interventions? The potential role of tamoxifen\u2013a single-center study. Perit Dial Int 2014;34:582\u201393.10.3747\/pdi.2012.0028624584614","DOI":"10.3747\/pdi.2012.00286"},{"key":"2026030213540710420_j_pp-2018-0103_ref_102_w2aab3b7b4b1b6b1ab1c10d102Aa","doi-asserted-by":"crossref","unstructured":"Zweers MM, Struijk DG, Smit W, Krediet RT. Vascular endothelial growth factor in peritoneal dialysis: a longitudinal follow-up. J Lab Clin Med 2001;137:125\u201332.10.1067\/mlc.2001.11223511174469","DOI":"10.1067\/mlc.2001.112235"},{"key":"2026030213540710420_j_pp-2018-0103_ref_103_w2aab3b7b4b1b6b1ab1c10d103Aa","doi-asserted-by":"crossref","unstructured":"Schmitt CP, Aufricht C. Is there such a thing as biocompatible peritoneal dialysis fluid? Pediatr Nephrol 2017;32:1835\u201343.2772278310.1007\/s00467-016-3461-y","DOI":"10.1007\/s00467-016-3461-y"},{"key":"2026030213540710420_j_pp-2018-0103_ref_104_w2aab3b7b4b1b6b1ab1c10d104Aa","doi-asserted-by":"crossref","unstructured":"Abrahams AC, Habib SM, Dendooven A, Riser BL, Van Der Veer JW, Toorop RJ, et\u2009al. Patients with encapsulating peritoneal sclerosis have increased peritoneal expression of connective tissue growth factor (CCN2), transforming growth factor-\u03b21, and vascular endothelial growth factor. PLoS One 2014;9:e112050.10.1371\/journal.pone.011205025384022","DOI":"10.1371\/journal.pone.0112050"},{"key":"2026030213540710420_j_pp-2018-0103_ref_105_w2aab3b7b4b1b6b1ab1c10d105Aa","doi-asserted-by":"crossref","unstructured":"Sampimon DE, Korte MR, Barreto DL, Vlijm A, de Waart DR, Struijk DG, et\u2009al. Early diagnostic markers for encapsulating peritoneal sclerosis \u2013 a case control study. Perit Dial Int 2010;30:163\u20139.10.3747\/pdi.2009.0002220124195","DOI":"10.3747\/pdi.2009.00022"},{"key":"2026030213540710420_j_pp-2018-0103_ref_106_w2aab3b7b4b1b6b1ab1c10d106Aa","doi-asserted-by":"crossref","unstructured":"Semchyshyn HM. Reactive carbonyl species in vivo: generation and dual biological effects. Sci World J 2014;2014:417842.","DOI":"10.1155\/2014\/417842"},{"key":"2026030213540710420_j_pp-2018-0103_ref_107_w2aab3b7b4b1b6b1ab1c10d107Aa","doi-asserted-by":"crossref","unstructured":"Flessner MF. The transport barrier in intraperitoneal therapy. Am J Physiol Renal Physiol 2005;288:F433\u201342.10.1152\/ajprenal.00313.200415692055","DOI":"10.1152\/ajprenal.00313.2004"},{"key":"2026030213540710420_j_pp-2018-0103_ref_108_w2aab3b7b4b1b6b1ab1c10d108Aa","doi-asserted-by":"crossref","unstructured":"Sa\u00efd-Sadier N, Ojcius D. Alarmins, inflammasomes and immunity. Biomed J 2012;35:437\u201349.10.4103\/2319-4170.10440823442356","DOI":"10.4103\/2319-4170.104408"},{"key":"2026030213540710420_j_pp-2018-0103_ref_109_w2aab3b7b4b1b6b1ab1c10d109Aa","doi-asserted-by":"crossref","unstructured":"El-Far AH. The role of receptors for advanced glycation end product in pancreatic carcinogenesis. Pancreat Disord Ther 2016;6:166.","DOI":"10.4172\/2165-7092.1000166"},{"key":"2026030213540710420_j_pp-2018-0103_ref_110_w2aab3b7b4b1b6b1ab1c10d110Aa","doi-asserted-by":"crossref","unstructured":"Pahl HL. Activators and target genes of Rel\/NF-kappaB transcription factors. Oncogene 1999;18:6853\u201366.1060246110.1038\/sj.onc.1203239","DOI":"10.1038\/sj.onc.1203239"},{"key":"2026030213540710420_j_pp-2018-0103_ref_111_w2aab3b7b4b1b6b1ab1c10d111Aa","doi-asserted-by":"crossref","unstructured":"Chu Y, Wang Y, Zheng Z, Lin Y, He R, Liu J, et\u2009al. Proinflammatory effect of high glucose concentrations on HMrSV5 cells via the autocrine effect of HMGB1. Front Physiol 2017;8:762.10.3389\/fphys.2017.0076229033853","DOI":"10.3389\/fphys.2017.00762"},{"key":"2026030213540710420_j_pp-2018-0103_ref_112_w2aab3b7b4b1b6b1ab1c10d112Aa","doi-asserted-by":"crossref","unstructured":"Padwal M, Margetts PJ. Experimental systems to study the origin of the myofibroblast in peritoneal fibrosis. Kidney Res Clin Pract 2016;35:133\u201341.10.1016\/j.krcp.2016.07.003","DOI":"10.1016\/j.krcp.2016.07.003"},{"key":"2026030213540710420_j_pp-2018-0103_ref_113_w2aab3b7b4b1b6b1ab1c10d113Aa","doi-asserted-by":"crossref","unstructured":"De Vriese AS, Tilton RG, Mortier S, Lameire NH. Myofibroblast transdifferentiation of mesothelial cells is mediated by RAGE and contributes to peritoneal fibrosis in uraemia. Nephrol Dial Transplant 2006;21:2549\u201355.1675749610.1093\/ndt\/gfl271","DOI":"10.1093\/ndt\/gfl271"},{"key":"2026030213540710420_j_pp-2018-0103_ref_114_w2aab3b7b4b1b6b1ab1c10d114Aa","doi-asserted-by":"crossref","unstructured":"Hirahara I, Sato H, Imai T, Onishi A, Morishita Y, Muto S, et\u2009al. Methylglyoxal induced basophilic spindle cells with podoplanin at the surface of peritoneum in rat peritoneal dialysis model. Biomed Res Int 2015;2015:289751.26064894","DOI":"10.1155\/2015\/289751"},{"key":"2026030213540710420_j_pp-2018-0103_ref_115_w2aab3b7b4b1b6b1ab1c10d115Aa","doi-asserted-by":"crossref","unstructured":"Ungefroren H, Sebens S, Groth S, Gieseler F, F\u00e4ndrich F. Differential roles of Src in transforming growth factor-\u00df regulation of growth arrest, epithelial-to-mesenchymal transition and cell migration in pancreatic ductal adenocarcinoma cells. Int J Oncol 2011;38:797\u2013805.21225226","DOI":"10.3892\/ijo.2011.897"},{"key":"2026030213540710420_j_pp-2018-0103_ref_116_w2aab3b7b4b1b6b1ab1c10d116Aa","unstructured":"Liu W, Shen SM, Zhao XY, Chen GQ. Targeted genes and interacting proteins of hypoxia inducible factor-1. Int J Biochem Mol Biol 2012;3:165\u201378.22773957"},{"key":"2026030213540710420_j_pp-2018-0103_ref_117_w2aab3b7b4b1b6b1ab1c10d117Aa","doi-asserted-by":"crossref","unstructured":"Wang X, Deng H, Zou F, Fu Z, Chen Y, Wang Z, et\u2009al. ER-\u03b136-mediated gastric cancer cell proliferation via the c-Src pathway. Oncol Lett 2013;6:329\u201335.10.3892\/ol.2013.141624137325","DOI":"10.3892\/ol.2013.1416"},{"key":"2026030213540710420_j_pp-2018-0103_ref_118_w2aab3b7b4b1b6b1ab1c10d118Aa","doi-asserted-by":"crossref","unstructured":"Mao L, Li Y, Zhao J, Li Q, Yang B, Wang Y, et\u2009al. Transforming growth factor-\u03b21 contributes to oxaliplatin resistance in colorectal cancer via epithelial to mesenchymal transition. Oncology Letters 2017;14:647\u201354.2869321710.3892\/ol.2017.6209","DOI":"10.3892\/ol.2017.6209"},{"key":"2026030213540710420_j_pp-2018-0103_ref_119_w2aab3b7b4b1b6b1ab1c10d119Aa","doi-asserted-by":"crossref","unstructured":"Brechbuhl HM, Finlay-Schultz J, Yamamoto TM, Gillen AE, Cittelly DM, Tan AC, et\u2009al. Fibroblast subtypes regulate responsiveness of luminal breast cancer to estrogen. Clin Cancer Res 2017;23:1710\u201321.2770282010.1158\/1078-0432.CCR-15-2851","DOI":"10.1158\/1078-0432.CCR-15-2851"},{"key":"2026030213540710420_j_pp-2018-0103_ref_120_w2aab3b7b4b1b6b1ab1c10d120Aa","doi-asserted-by":"crossref","unstructured":"Singel KL, Segal BH. Neutrophils in the tumor microenvironment: trying to heal the wound that cannot heal. Immunol Rev 2016;273:329\u201343.10.1111\/imr.1245927558344","DOI":"10.1111\/imr.12459"},{"key":"2026030213540710420_j_pp-2018-0103_ref_121_w2aab3b7b4b1b6b1ab1c10d121Aa","doi-asserted-by":"crossref","unstructured":"Zhu Y, Zhang Y, Sui Z, Zhang Y, Liu M, Tang H. USP14 de-ubiquitinates vimentin and miR-320a modulates USP14 and vimentin to contribute to malignancy in gastric cancer cells. Oncotarget 2017;8:48725\u201336.27448976","DOI":"10.18632\/oncotarget.10706"},{"key":"2026030213540710420_j_pp-2018-0103_ref_122_w2aab3b7b4b1b6b1ab1c10d122Aa","doi-asserted-by":"crossref","unstructured":"Bongarzone S, Savickas V, Luzi F, Gee AD. Targeting the receptor for advanced glycation endproducts (RAGE): a medicinal chemistry perspective. J Med Chem 2017;60:7213\u201332.2848215510.1021\/acs.jmedchem.7b00058","DOI":"10.1021\/acs.jmedchem.7b00058"},{"key":"2026030213540710420_j_pp-2018-0103_ref_123_w2aab3b7b4b1b6b1ab1c10d123Aa","doi-asserted-by":"crossref","unstructured":"Huang S, Wei P, Hwang\u2010Verslues WW, Kuo W, Jeng Y, Hu C, et\u2009al. TGF\u2010\u03b21 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up\u2010regulation of IL\u201017RB. EMBO Mol Med 2017;9:1660\u201380.10.15252\/emmm.20160691428993429","DOI":"10.15252\/emmm.201606914"},{"key":"2026030213540710420_j_pp-2018-0103_ref_124_w2aab3b7b4b1b6b1ab1c10d124Aa","doi-asserted-by":"crossref","unstructured":"Takemoto A, Miyata K, Fujita N. Platelet-activating factor podoplanin: from discovery to drug development. Cancer Metastasis Rev 2017;36:225\u201334.10.1007\/s10555-017-9672-228674748","DOI":"10.1007\/s10555-017-9672-2"},{"key":"2026030213540710420_j_pp-2018-0103_ref_125_w2aab3b7b4b1b6b1ab1c10d125Aa","doi-asserted-by":"crossref","unstructured":"Placke T, \u00d6rgel M, Schaller M, Jung G, Rammensee HG, Kopp HG, et\u2009al. Platelet-derived MHC class I confers a pseudonormal phenotype to cancer cells that subverts the antitumor reactivity of natural killer immune cells. Cancer Res 2012;72:440\u20138.2212792510.1158\/0008-5472.CAN-11-1872","DOI":"10.1158\/0008-5472.CAN-11-1872"},{"key":"2026030213540710420_j_pp-2018-0103_ref_126_w2aab3b7b4b1b6b1ab1c10d126Aa","doi-asserted-by":"crossref","unstructured":"Placke T, Salih HR, Kopp HG. GITR ligand provided by thrombopoietic cells inhibits NK cell antitumor activity. J Immunol 2012;189:154\u201360.10.4049\/jimmunol.110319422649191","DOI":"10.4049\/jimmunol.1103194"},{"key":"2026030213540710420_j_pp-2018-0103_ref_127_w2aab3b7b4b1b6b1ab1c10d127Aa","doi-asserted-by":"crossref","unstructured":"Erices R, Cubillos S, Aravena R, Santoro F, Marquez M, Orellana R, et\u2009al. Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression. Oncotarget 2017;8:20865\u201380.28209916","DOI":"10.18632\/oncotarget.15348"},{"key":"2026030213540710420_j_pp-2018-0103_ref_128_w2aab3b7b4b1b6b1ab1c10d128Aa","unstructured":"Li DP, Fan J, Wu YJ, Xie YF, Zha JM, Zhou XM. MiR-155 up-regulated by TGF-\u03b2 promotes epithelial-mesenchymal transition, invasion and metastasis of human hepatocellular carcinoma cells in vitro. Am J Transl Res 2017;9:2956\u201365.28670383"},{"key":"2026030213540710420_j_pp-2018-0103_ref_129_w2aab3b7b4b1b6b1ab1c10d129Aa","doi-asserted-by":"crossref","unstructured":"Wigerup C, P\u00e5hlman S, Bexell D. Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. Pharmacol Ther 2016;164:152\u201369.10.1016\/j.pharmthera.2016.04.00927139518","DOI":"10.1016\/j.pharmthera.2016.04.009"},{"key":"2026030213540710420_j_pp-2018-0103_ref_130_w2aab3b7b4b1b6b1ab1c10d130Aa","doi-asserted-by":"crossref","unstructured":"Chen XL, Chen ZQ, Zhu SL, Liu TW, Wen Y, Su YS, et\u2009al. Prognostic value of transforming growth factor-beta in patients with colorectal cancer who undergo surgery: a meta-analysis. BMC Cancer 2017;4:240.28376764","DOI":"10.1186\/s12885-017-3215-7"},{"key":"2026030213540710420_j_pp-2018-0103_ref_131_w2aab3b7b4b1b6b1ab1c10d131Aa","doi-asserted-by":"crossref","unstructured":"Salazar R, Roepman P, Willems SM, Brunen D, Kellner U, Midgley RA, et\u2009al. Molecular subtyping of colorectal cancer to identify a mesenchymal tumor type that might benefit from TGF-beta pathway inhibition. J Clin Oncol 2014;32:456.10.1200\/jco.2014.32.3_suppl.456","DOI":"10.1200\/jco.2014.32.3_suppl.456"},{"key":"2026030213540710420_j_pp-2018-0103_ref_132_w2aab3b7b4b1b6b1ab1c10d132Aa","doi-asserted-by":"crossref","unstructured":"Saito T, Kurashige J, Nambara S, Komatsu H, Hirata H, Ueda M, et\u2009al. A long non-coding RNA activated by transforming growth factor-\u03b2 is an independent prognostic marker of gastric cancer. Ann Surg Oncol 2015;22:S915\u201322.10.1245\/s10434-015-4554-825986864","DOI":"10.1245\/s10434-015-4554-8"},{"key":"2026030213540710420_j_pp-2018-0103_ref_133_w2aab3b7b4b1b6b1ab1c10d133Aa","doi-asserted-by":"crossref","unstructured":"Fan YH, Ji CX, Xu B, Fan HY, Cheng ZJ, Zhu XG. Long noncoding RNA activated by TGF-\u03b2 in human cancers: a meta-analysis. Clin Chim Acta 2017;468:10\u20136.10.1016\/j.cca.2017.02.00128163033","DOI":"10.1016\/j.cca.2017.02.001"},{"key":"2026030213540710420_j_pp-2018-0103_ref_134_w2aab3b7b4b1b6b1ab1c10d134Aa","doi-asserted-by":"crossref","unstructured":"Yang Y, Junjie P, Sanjun C, Ma Y. Long non-coding RNAs in colorectal cancer: progression and future directions. J Cancer 2017;8:3212\u20135.10.7150\/jca.1979429158793","DOI":"10.7150\/jca.19794"},{"key":"2026030213540710420_j_pp-2018-0103_ref_135_w2aab3b7b4b1b6b1ab1c10d135Aa","doi-asserted-by":"crossref","unstructured":"Watanabe T, Hashimoto T, Sugino T, Soeda S, Nishiyama H, Morimura Y, et\u2009al. Production of IL1-beta by ovarian cancer cells induces mesothelial cell beta1-integrin expression facilitating peritoneal dissemination. J Ovarian Res 2012;5:7.2229675710.1186\/1757-2215-5-7","DOI":"10.1186\/1757-2215-5-7"},{"key":"2026030213540710420_j_pp-2018-0103_ref_136_w2aab3b7b4b1b6b1ab1c10d136Aa","doi-asserted-by":"crossref","unstructured":"Rynne-Vidal A, Au-Yeung CL, Jim\u00e9nez-Heffernan JA, P\u00e9rez-Lozano ML, Cremades-Jimeno L, B\u00e1rcena C, et\u2009al. Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer. J Pathol 2017;242:140\u201351.2824741310.1002\/path.4889","DOI":"10.1002\/path.4889"},{"key":"2026030213540710420_j_pp-2018-0103_ref_137_w2aab3b7b4b1b6b1ab1c10d137Aa","doi-asserted-by":"crossref","unstructured":"Rynne-Vidal A, Jim\u00e9nez-Heffernan JA, Fern\u00e1ndez-Chac\u00f3n C, L\u00f3pez-Cabrera M, Sandoval P. The mesothelial origin of carcinoma associated-fibroblasts in peritoneal metastasis. Cancers (Basel) 2015;7:1994\u20132011.2642605410.3390\/cancers7040872","DOI":"10.3390\/cancers7040872"},{"key":"2026030213540710420_j_pp-2018-0103_ref_138_w2aab3b7b4b1b6b1ab1c10d138Aa","doi-asserted-by":"crossref","unstructured":"Mikula-Pietrasik J, Sosinska P, Kucinska M, Murias M, Maksin K, Malinska A, et\u2009al. Peritoneal mesothelium promotes the progression of ovarian cancer cells in vitro and in a mice xenograft model in vivo. Cancer Lett 2014;355:310\u20135.10.1016\/j.canlet.2014.09.041","DOI":"10.1016\/j.canlet.2014.09.041"},{"key":"2026030213540710420_j_pp-2018-0103_ref_139_w2aab3b7b4b1b6b1ab1c10d139Aa","doi-asserted-by":"crossref","unstructured":"Tsukada T, Fushida S, Harada S, Yagi Y, Kinoshita J, Oyama K, et\u2009al. The role of human peritoneal mesothelial cells in the fibrosis and progression of gastric cancer. Int J Oncol 2012;41:476\u201382.10.3892\/ijo.2012.149022614335","DOI":"10.3892\/ijo.2012.1490"},{"key":"2026030213540710420_j_pp-2018-0103_ref_140_w2aab3b7b4b1b6b1ab1c10d140Aa","doi-asserted-by":"crossref","unstructured":"Crespigio J, Berbel LCL, Dias MA, Berbel RF, Pereira SS, Pignatelli D, et\u2009al. Von Hippel-Lindau disease: a single gene, several hereditary tumors. J Endocrinol Invest 2018;41:21\u201331.10.1007\/s40618-017-0683-128589383","DOI":"10.1007\/s40618-017-0683-1"},{"key":"2026030213540710420_j_pp-2018-0103_ref_141_w2aab3b7b4b1b6b1ab1c10d141Aa","doi-asserted-by":"crossref","unstructured":"Chen JL, Walton KL, Hagg A, Colgan TD, Johnson K, Qian H, et\u2009al. Specific targeting of TGF-\u03b2 family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease. Proc Natl Acad Sci U S A 2017;114:E5266\u2013E5275.","DOI":"10.1073\/pnas.1620013114"},{"key":"2026030213540710420_j_pp-2018-0103_ref_142_w2aab3b7b4b1b6b1ab1c10d142Aa","doi-asserted-by":"crossref","unstructured":"Pollacco J, Sacco K, Portelli M, Schembri-Wismayer P, Calleja-Agius J. Molecular links between endometriosis and cancer. Gynecol Endocrinol 2012;28:577\u201381.10.3109\/09513590.2011.65076122309646","DOI":"10.3109\/09513590.2011.650761"},{"key":"2026030213540710420_j_pp-2018-0103_ref_143_w2aab3b7b4b1b6b1ab1c10d143Aa","doi-asserted-by":"crossref","unstructured":"Vigan\u00f3 P, Somigliana E, Chiodo I, Abbiati A, Vercellini P. Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis. Hum Reprod Update 2006;12:77\u201389.10.1093\/humupd\/dmi03716172112","DOI":"10.1093\/humupd\/dmi037"},{"key":"2026030213540710420_j_pp-2018-0103_ref_144_w2aab3b7b4b1b6b1ab1c10d144Aa","doi-asserted-by":"crossref","unstructured":"Proestling K, Birner P, Gamperl S, Nirtl N, Marton E, Yerlikaya G, et\u2009al. Enhanced epithelial to mesenchymal transition (EMT) and upregulated MYC in ectopic lesions contribute independently to endometriosis. Reprod Biol Endocrinol 2015;13:75.2619805510.1186\/s12958-015-0063-7","DOI":"10.1186\/s12958-015-0063-7"},{"key":"2026030213540710420_j_pp-2018-0103_ref_145_w2aab3b7b4b1b6b1ab1c10d145Aa","doi-asserted-by":"crossref","unstructured":"Bischoff FZ, Heard M, Simpson JL. Somatic DNA alterations in endometriosis: high frequency of chromosome 17 and p53 loss in late stage endometriosis. J Reprod Immunol 2002;55:49\u201364.1206282110.1016\/S0165-0378(01)00131-0","DOI":"10.1016\/S0165-0378(01)00131-0"},{"key":"2026030213540710420_j_pp-2018-0103_ref_146_w2aab3b7b4b1b6b1ab1c10d146Aa","doi-asserted-by":"crossref","unstructured":"Kawahara N, Ogawa K, Nagayasu M, Kimura M, Sasaki Y, Kobayashi H. Candidate synthetic lethality partners to PARP inhibitors in the treatment of ovarian clear cell cancer. Biomed Rep 2017;7:391\u201399.10.3892\/br.2017.99029109859","DOI":"10.3892\/br.2017.990"},{"key":"2026030213540710420_j_pp-2018-0103_ref_147_w2aab3b7b4b1b6b1ab1c10d147Aa","doi-asserted-by":"crossref","unstructured":"Shin JC, Ross HL, Elias S, Nguyen DD, Mitchell-Leef D, Simpson JL, et\u2009al. Detection of chromosomal aneuploidy in endometriosis by multi-color fluorescence in situ hybridization (FISH). Hum Genet 1997;100:401\u20136.10.1007\/s0043900505249272163","DOI":"10.1007\/s004390050524"},{"key":"2026030213540710420_j_pp-2018-0103_ref_148_w2aab3b7b4b1b6b1ab1c10d148Aa","doi-asserted-by":"crossref","unstructured":"Rojas V, Hirshfield KM, Ganesan S, Rodriguez-Rodriguez L. Molecular characterization of epithelial ovarian cancer: implications for diagnosis and treatment. Wong K-K, ed. Int J Mol Sci 2016;17:2113.10.3390\/ijms17122113","DOI":"10.3390\/ijms17122113"},{"key":"2026030213540710420_j_pp-2018-0103_ref_149_w2aab3b7b4b1b6b1ab1c10d149Aa","doi-asserted-by":"crossref","unstructured":"Otsuka J, Okuda T, Sekizawa A, Amemiya S, Saito H, Okai T, et\u2009al. K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma. Med Electron Microsc 2004 Sep;37:188\u201392.15449112","DOI":"10.1007\/s00795-004-0252-5"},{"key":"2026030213540710420_j_pp-2018-0103_ref_150_w2aab3b7b4b1b6b1ab1c10d150Aa","doi-asserted-by":"crossref","unstructured":"Chang CM, Yang YP, Chuang JH, Chuang CM, Lin TW, Wang PH, et\u2009al. Discovering the deregulated molecular functions involved in malignant transformation of endometriosis to endometriosis-associated ovarian carcinoma using a data-driven, function-based analysis. Int J Mol Sci 2017;18:2345.10.3390\/ijms18112345","DOI":"10.3390\/ijms18112345"},{"key":"2026030213540710420_j_pp-2018-0103_ref_151_w2aab3b7b4b1b6b1ab1c10d151Aa","doi-asserted-by":"crossref","unstructured":"Yang YM, Yang WX. Epithelial-to-mesenchymal transition in the development of endometriosis. Oncotarget 2017;8:41679\u201389.28415639","DOI":"10.18632\/oncotarget.16472"},{"key":"2026030213540710420_j_pp-2018-0103_ref_152_w2aab3b7b4b1b6b1ab1c10d152Aa","doi-asserted-by":"crossref","unstructured":"Worzfeld T, Pogge Von Strandmann E, Huber M, Adhikary T, Wagner U, Reinartz S, et\u2009al. The unique molecular and cellular microenvironment of ovarian cancer. Front Oncol 2017;7:24.28275576","DOI":"10.3389\/fonc.2017.00024"}],"container-title":["Pleura and Peritoneum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/pp\/3\/1\/article-20180103.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/pp-2018-0103\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/pp-2018-0103\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:55:32Z","timestamp":1772459732000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/pp-2018-0103\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,1]]},"references-count":152,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,3,29]]},"published-print":{"date-parts":[[2018,3,26]]}},"alternative-id":["10.1515\/pp-2018-0103"],"URL":"https:\/\/doi.org\/10.1515\/pp-2018-0103","relation":{},"ISSN":["2364-768X","2364-7671"],"issn-type":[{"value":"2364-768X","type":"electronic"},{"value":"2364-7671","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3,1]]},"article-number":"20180103"}}