{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:36:19Z","timestamp":1790339779753,"version":"4.1.0"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2018-0106_s_005_w2aab3b7b6b1b6b1aab1c16b1Aa\">\n                    <jats:title id=\"d3156347e20244_w2aab3b7b6b1b6b1aab1c16b1aAa\">Background<\/jats:title>\n                    <jats:p>The aim of this systematic review was to investigate the accuracy of additional staging laparoscopy (SL) in advanced epithelial ovarian cancer (AEOC) to predict futile laparotomy (FL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2018-0106_s_006_w2aab3b7b6b1b6b1aab1c16b2Aa\">\n                    <jats:title id=\"d3156347e20253_w2aab3b7b6b1b6b1aab1c16b2aAa\">Methods<\/jats:title>\n                    <jats:p>Systematic review according to preferred reporting items for systematic reviews and meta-analyses statement (PRISMA) criteria. Clinical studies investigating the role of SL in selecting women with AEOC for primary debulking surgery (PDS) were included. Index test: SL. Reference test: laparotomy. Target condition: incomplete cytoreduction (CR) with remaining disease&lt;1\u2006cm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2018-0106_s_007_w2aab3b7b6b1b6b1aab1c16b3Aa\">\n                    <jats:title id=\"d3156347e20262_w2aab3b7b6b1b6b1aab1c16b3aAa\">Results<\/jats:title>\n                    <jats:p>Nine prospective and retrospective studies reporting on eight cohorts totalizing 778 LS were included. Reference test was completed in 76\u2006% cases. PPV for FL was between 0.69 and 1.0. In three studies examining the value of a predictive index value (PIV) for predicting FL, sensitivity of the index test (LS with PIV \u22658) was between 46\u2006% and 70\u2006%, and specificity between 89\u2006% and 100\u2006%. The proportion of patients that received CR during PDS differed widely between studies (from 50 to 91). Using a PIV did not increase the sensitivity and might result in more patients receiving FL. In the only randomized trial, FL occurred in 10 (10\u2006%) of 102 patients in the LS group versus 39 (39\u2006%) of 99 patients in the primary PDS group (relative risk, 0.25; 95\u2006% CI, 0.13\u20130.47; p&lt;0.001). Port-site recurrences occurred in 2%\u20136\u2006% patients. Overall costs of with or without SL were comparable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2018-0106_s_008_w2aab3b7b6b1b6b1aab1c16b4Aa\">\n                    <jats:title id=\"d3156347e20271_w2aab3b7b6b1b6b1aab1c16b4aAa\">Conclusions<\/jats:title>\n                    <jats:p>The evidence available from this systematic review supports the inclusion of an additional LS to the conventional initial diagnostic workup in women with AEOC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2018-0106","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T10:58:34Z","timestamp":1522839514000},"source":"Crossref","is-referenced-by-count":14,"title":["Role of laparoscopy in initial tumour staging in advanced epithelial ovarian cancer: a systematic review"],"prefix":"10.1515","volume":"3","author":[{"given":"Natalia","family":"Zeff","sequence":"first","affiliation":[{"name":"Gynecology Oncology , Institute of Oncology \u201cAngel H. 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