{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:43:20Z","timestamp":1790516600112,"version":"4.1.0"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2018-0113_s_011_w2aab3b7b4b1b6b1aab1c17b1Aa\">\n                    <jats:title id=\"d8956950e7321_w2aab3b7b4b1b6b1aab1c17b1aAa\">Background<\/jats:title>\n                    <jats:p>Peritoneal metastasis is a common and dismal evolution of several gastrointestinal (GI) tumors, including gastric, colorectal, hepatobiliary, pancreatic, and other cancers. The therapy of peritoneal metastasis is largely palliative; with the aim of prolonging life and preserving its quality. In the meantime, a significant pharmacological advantage of intraperitoneal chemotherapy was documented in the preclinical model, and numerous clinical studies have delivered promising clinical results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2018-0113_s_012_w2aab3b7b4b1b6b1aab1c17b2Aa\">\n                    <jats:title id=\"d8956950e7330_w2aab3b7b4b1b6b1aab1c17b2aAa\">Methods<\/jats:title>\n                    <jats:p>This is a prospective, open, randomized multicenter phase III clinical study with two arms that aims to evaluate the effects of pressurized intraperitoneal aerosol chemotherapy (PIPAC) combined with systemic chemotherapy vs. intravenous systemic chemotherapy alone on patients with metastatic upper GI tumors with a peritoneal seeding. Upper GI-adenocarcinomas originated from biliary tract, pancreas and stomach, or esophago- gastric junction are eligible. Patients in the study are treated with standard of care systemic palliative chemotherapy (mFOLFOX6) vs. PIPAC with intravenous (i.v.) chemotherapy (mFOLFOX6). Patients in first line with first diagnosed peritoneal seeding are eligible. Primary outcome is progression free survival (PFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2018-0113_s_013_w2aab3b7b4b1b6b1aab1c17b3Aa\">\n                    <jats:title id=\"d8956950e7339_w2aab3b7b4b1b6b1aab1c17b3aAa\">Conclusions<\/jats:title>\n                    <jats:p>PIPAC-procedure is explicit a palliative method but it delivers cytotoxic therapy like in hyperthermic intraperitoneal chemotherapy (HIPEC)-procedure directly to the tumor in a minimally invasive technique, without the need for consideration of the peritoneal-plasma barrier. The technique of PIPAC is minimally invasive and very gentle and the complete procedure takes only round about 45\u2006min and, therefore, optimal in a clearly palliative situation where cure is not the goal. It is also ideal for using this approach in a first line situation, where deepest response should be achieved. The symbiosis of systemic therapy and potentially effective surgery has to be well-planned without deterioration of the patient due to aggressive way of surgery like in cytoreductive surgery (CRS)+HIPEC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2018-0113_s_014_w2aab3b7b4b1b6b1aab1c17b4Aa\">\n                    <jats:title id=\"d8956950e7348_w2aab3b7b4b1b6b1aab1c17b4aAa\">Trial registration<\/jats:title>\n                    <jats:p>EudraCT: 2018-001035-40.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2018-0113","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T18:17:31Z","timestamp":1528481851000},"source":"Crossref","is-referenced-by-count":20,"title":["Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in combination with standard of care chemotherapy in primarily untreated chemo na\u00efve upper gi-adenocarcinomas with peritoneal seeding \u2013 a phase II\/III trial of the AIO\/CAOGI\/ACO"],"prefix":"10.1515","volume":"3","author":[{"given":"Thorsten","family":"Oliver Goetze","sequence":"first","affiliation":[{"name":"Institute of Clinical Cancer Research (IKF) , UCT- University Cancer Center Frankfurt , Krankenhaus Nordwest , Frankfurt am Main , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah-Eddin","family":"Al-Batran","sequence":"additional","affiliation":[{"name":"Institute of Clinical Cancer Research (IKF) , UCT- University Cancer Center Frankfurt , Krankenhaus Nordwest , Frankfurt am Main , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Pabst","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Chirurgie Marien Hospital Herne , Universit\u00e4tsklinikum der Ruhr-Universit\u00e4t BochumHerne , Herne , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Reymond","sequence":"additional","affiliation":[{"name":"Chirurgische Klinik , Universit\u00e4tsklinikum T\u00fcbingen , T\u00fcbingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Tempfer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Frauenheilkunde Marien Hospital Herne , Universit\u00e4tsklinikum der Ruhr-Universit\u00e4t Bochum , Herne , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf O.","family":"Bechstein","sequence":"additional","affiliation":[{"name":"Department of Surgery , Frankfurt University; Hospital , Frankfurt , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulli","family":"Bankstahl","sequence":"additional","affiliation":[{"name":"Institute of Clinical Cancer Research (IKF) , UCT- University Cancer Center Frankfurt , Krankenhaus Nordwest , Frankfurt am Main , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Gockel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Visceralchirurgie , Universit\u00e4tsklinikum Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"K\u00f6nigsrainer","sequence":"additional","affiliation":[{"name":"Chirurgische Klinik , Universit\u00e4tsklinikum T\u00fcbingen , T\u00fcbingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kraus","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Chirurgie , UCT- University Cancer Center Frankfurt , Krankenhaus Nordwest , Frankfurt am Main , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan P.","family":"M\u00f6nig","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaires , de Gen\u00e8ve, Service de Chirurgie visc\u00e9ral , Gen\u00e8ve , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Rau","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin , Chirurgische Klinik , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schwarzbach","sequence":"additional","affiliation":[{"name":"Department of Surgery , Klinikum Frankfurt H\u00f6chst , Frankfurt , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pompiliu","family":"Piso","sequence":"additional","affiliation":[{"name":"Chirurgische Klinik , Krankenhaus Barmherzige Br\u00fcder Regensburg , Regensburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,6,8]]},"reference":[{"key":"2025120909215700600_j_pp-2018-0113_ref_001_w2aab3b7b4b1b6b1ab1b5b1Aa","doi-asserted-by":"crossref","unstructured":"Lambert LA. 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