{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:22:28Z","timestamp":1785867748602,"version":"3.56.0"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2018-0127_s_001_w2aab3b7b2b1b6b1aab1c16b1Aa\">\n                    <jats:title id=\"d1045851e2614_w2aab3b7b2b1b6b1aab1c16b1aAa\">Background<\/jats:title>\n                    <jats:p>The quest to cure or to contain the disease in cancer patients leads to new strategies and techniques being added to the armamentarium of oncologists. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is a recently described surgical technique which is being evaluated at many centers for the management of peritoneal metastasis (PM). The present study is a systematic review to evaluate the current role of PIPAC in the management of gastric cancer associated PM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2018-0127_s_002_w2aab3b7b2b1b6b1aab1c16b2Aa\">\n                    <jats:title id=\"d1045851e2622_w2aab3b7b2b1b6b1aab1c16b2aAa\">Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted in Pubmed and EMBASE database using relevant keywords and confirming to the PRISMA guidelines to identify the articles describing the role of PIPAC in gastric cancer associated PM. All the studies which were published prior to July 1, 2018 in English literature and reported the role of PIPAC in gastric cancer associated PM were included in the systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2018-0127_s_003_w2aab3b7b2b1b6b1aab1c16b3Aa\">\n                    <jats:title id=\"d1045851e2630_w2aab3b7b2b1b6b1aab1c16b3aAa\">Results<\/jats:title>\n                    <jats:p>The search yielded 79 articles; there were ten published studies which have reported the use of PIPAC in gastric cancer associated PM. A total of 129 patients with gastric cancer associated PM were treated in the studies. Only two studies had an exclusive cohort of gastric cancer patients while eight other studies had a heterogeneous population with a small proportion of gastric cancer patients. There was only one study highlighting the role of PIPAC in neoadjuvant setting to downgrade the peritoneal carcinomatosis index. All the studies revealed that PIPAC is feasible and has minimal perioperative morbidity, even after repeated applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2018-0127_s_004_w2aab3b7b2b1b6b1aab1c16b4Aa\">\n                    <jats:title id=\"d1045851e2638_w2aab3b7b2b1b6b1aab1c16b4aAa\">Conclusion<\/jats:title>\n                    <jats:p>There is a scarcity of English literature related to the role of PIPAC in gastric cancer associated PM. PIPAC is a safe and well-tolerated procedure which has the potential to contain spreading PM. Further studies are warranted to better define the role of PIPAC in gastric cancer associated PM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2018-0127","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T04:10:57Z","timestamp":1551759057000},"source":"Crossref","is-referenced-by-count":29,"title":["The role of Pressurized IntraPeritoneal Aerosol Chemotherapy in the management of gastric cancer: A systematic review"],"prefix":"10.1515","volume":"4","author":[{"given":"Pankaj Kumar","family":"Garg","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology , All India Institute of Medical Sciences , Rishikesh, Uttarakhand , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Jara","sequence":"additional","affiliation":[{"name":"Department of General Surgery , Campus Virchow Klinikum, Charit\u00e9, Universit\u00e4tsmedizin Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Alberto","sequence":"additional","affiliation":[{"name":"Department of General Surgery , Campus Virchow Klinikum, Charit\u00e9, Universit\u00e4tsmedizin Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Rau","sequence":"additional","affiliation":[{"name":"Department of General Surgery , Campus Virchow Klinikum, Charit\u00e9, Universit\u00e4tsmedizin Berlin , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,3,26]]},"reference":[{"key":"2025120909211364285_j_pp-2018-0127_ref_001_w2aab3b7b2b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Wagner AD, Syn NL, Moehler M, Grothe W, Yong WP, Tai B-C, et\u2009al. Chemotherapy for advanced gastric cancer. Cochrane Database Syst Rev. 2017;29:CD004064.","DOI":"10.1002\/14651858.CD004064.pub4"},{"key":"2025120909211364285_j_pp-2018-0127_ref_002_w2aab3b7b2b1b6b1ab1b6b2Aa","unstructured":"Ajani JA, D\u2019Amico TA, Almhanna K, Bentrem DJ, Chao J, Das P, et\u2009al. Gastric cancer, version 3.2016, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw JNCCN. 2016;14:1286\u2013312.10.6004\/jnccn.2016.0137"},{"key":"2025120909211364285_j_pp-2018-0127_ref_003_w2aab3b7b2b1b6b1ab1b6b3Aa","doi-asserted-by":"crossref","unstructured":"Morales-Soriano R, Esteve-P\u00e9rez N, Segura-Sampedro JJ, Cascales-Campos P, Barrios P. Spanish Group of Peritoneal Malignancy Surface (GECOP). Current practice in cytoreductive surgery and HIPEC for metastatic peritoneal disease: Spanish multicentric survey. 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