{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:11:00Z","timestamp":1765278660618,"version":"3.46.0"},"reference-count":9,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,25]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Heated intraperitoneal chemotherapy (HIPEC) is currently performed using an external circuit including a heating device and a pump. Available devices have several drawbacks in terms of costs, technique (flow surges due to blocked tubes) and staff safety, hindering a wider use. In a previous preclinical study conducted in animals, we placed a heating wire within the abdomen to achieve and maintain hyperthermia. Our results showed this technique is safe and effective. The present pilot study was conceived as the first use of such a device in humans, aiming to confirm its safety and efficacy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This was a pilot study designed to include 13 patients undergoing HIPEC. Two sets of the prototype were placed within the abdominal cavity, one in the supramesocolic and one in the inframesocolic space. The target temperature was 42\u201343\u2006\u00b0C during 30\u201390\u2006min according to the protocol defined for each patient. The time to set up, heat and dismantle was measured. All complications were recorded during the first postoperative year and evaluated by an independent committee.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Nine women and four men were included. The median time to set on the device was 25\u2006min. The target temperature was obtained in a median of 14\u2006min and maintained uniform and homogeneously distributed within the abdomen for the scheduled duration. A permanent stirring of the viscera was performed. No thermal injury or device-related complications were observed. There were two anastomotic leaks (only one requiring reoperation), two hemoperitoneum requiring reoperation, one evisceration and one gastroparesia.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A heating cable within the peritoneal cavity can achieve safe, simple, fast and efficient HIPEC.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/pp-2019-0008","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T05:02:37Z","timestamp":1564117357000},"source":"Crossref","is-referenced-by-count":0,"title":["CHIPOFIL: A pilot study assessing the feasibility of HIPEC without extracorporeal circuit"],"prefix":"10.1515","volume":"4","author":[{"given":"Pablo","family":"Ortega-Deballon","sequence":"first","affiliation":[{"name":"Digestive Surgical Oncology , Equipe Avenir , 14 rue Paul Gaffarel , Dijon 21079 , France"},{"name":"Service de Chirurgie Digestive et Canc\u00e9rologique , CHU Bocage Central , 14, rue Paul Gaffarel , Dijon Cedex 21079 , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Facy","sequence":"additional","affiliation":[{"name":"Digestive Surgical Oncology , University Hospital of Dijon , Dijon , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Binquet","sequence":"additional","affiliation":[{"name":"CIC Epid\u00e9miologie Clinique , INSERM CR 1231 , Dijon , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Delroeux","sequence":"additional","affiliation":[{"name":"Digestive Surgical Oncology , University Hospital of Besan\u00e7on , Besan\u00e7on , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Rat","sequence":"additional","affiliation":[{"name":"Digestive Surgical Oncology , University Hospital of Dijon , Dijon , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Glehen O, Cotte E, Kusamura S, Deraco M, Baratti D, Passot G, et al. Hyperthermic intraperitoneal chemotherapy: nomenclature and modalities of perfusion. J Surg Oncol 2008;98:242\u20136.1872688510.1002\/jso.21061","key":"2025120909273569960_j_pp-2019-0008_ref_001_w2aab3b7b2b1b6b1ab1b6b1Aa","DOI":"10.1002\/jso.21061"},{"doi-asserted-by":"crossref","unstructured":"Ortega-Deballon P, Facy O, Magnin G, Piard F, Chauffert B, Rat P. Using a heating cable within the abdomen to make hyperthermic intraperitoneal chemotherapy easier: feasibility and safety study in a pig model. Eur J Surg Oncol 2010;36:324\u20138.10.1016\/j.ejso.2009.11.010","key":"2025120909273569960_j_pp-2019-0008_ref_002_w2aab3b7b2b1b6b1ab1b6b2Aa","DOI":"10.1016\/j.ejso.2009.11.010"},{"doi-asserted-by":"crossref","unstructured":"Ortega-Deballon P, Facy O, Jambet S, Magnin G, Cotte E, Beltramo JL, et al. Which method to deliver hyperthermic intraperitoneal chemotherapy with oxaliplatin? An experimental comparison of open and closed techniques. 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