{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:51:34Z","timestamp":1787226694743,"version":"build-2736575974"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2020-0144_abs_001_w2aab3b7c16b1b6b1aab1c15b1Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The National Mesothelioma Audit 2020 showed Northumbria to have low rates of histopathological confirmation, treatment and one-year survival rates for malignant pleural mesothelioma (MPM). We hypothesized that an internal analysis over a 10-year period provides valuable insights into presentation, diagnosis, treatment and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2020-0144_abs_002_w2aab3b7c16b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single-centre retrospective case series of all confirmed MPM patients between 1 January 2009 and 31 December 2019 was performed. Demographics, clinical, radiological and histopathological characteristics and outcomes were collected. Statistical analysis was performed using SPSS V26.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2020-0144_abs_003_w2aab3b7c16b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 247 patients had MPM. About 86% were male, mean age 75.7 years. Dyspnoea (77.4%) and chest pain (38.5%) were commonest symptoms. 64.9 and 71.4% had pleural thickening and effusion, respectively. About 86.8% had at least one attempt to obtain a tissue biopsy, but histopathological confirmation in only 108 (43.7%). About 66.3% with PS 0 and 1 (62.7% of total cohort) had at least one anti-cancer therapy. Death within 12\u00a0months was\u00a0associated with disease progression within 6\u00a0months (p\u22640.001). Chemotherapy (p\u22640.001) and epithelioid histological subtype (p=0.01) were protective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2020-0144_abs_004_w2aab3b7c16b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study confirms known epidemiology of\u00a0MPM, demonstrates variability in practices and highlights how some NMA recommendations are not met. This provides the incentive for a regional mesothelioma multi-disciplinary meeting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2020-0144","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T08:10:32Z","timestamp":1608624632000},"page":"13-19","source":"Crossref","is-referenced-by-count":5,"title":["A review of malignant pleural mesothelioma in a large North East UK pleural centre"],"prefix":"10.1515","volume":"6","author":[{"given":"Declan C.","family":"Murphy","sequence":"first","affiliation":[{"name":"Northumbria HealthCare NHS Foundation Trust, Care of Tracy Groom , Cramlington , Northumberland , UK"},{"name":"Institute of Genetic Medicine, Newcastle University , Newcastle upon Tyne , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Mount","sequence":"additional","affiliation":[{"name":"Northumbria HealthCare NHS Foundation Trust, Care of Tracy Groom , Cramlington , Northumberland , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Starkie","sequence":"additional","affiliation":[{"name":"Northumbria HealthCare NHS Foundation Trust, Care of Tracy Groom , Cramlington , Northumberland , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Taylor","sequence":"additional","affiliation":[{"name":"Northumbria HealthCare NHS Foundation Trust, Care of Tracy Groom , Cramlington , Northumberland , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0859-5550","authenticated-orcid":false,"given":"Avinash","family":"Aujayeb","sequence":"additional","affiliation":[{"name":"Northumbria HealthCare NHS Foundation Trust, Care of Tracy Groom , Cramlington , Northumberland , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"2025120909232009528_j_pp-2020-0144_ref_001_w2aab3b7c16b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Rake, C, Gilham, C, Hatch, J, Darnton, A, Hodgson, J, Peto, J. 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