{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:50:20Z","timestamp":1792839020512,"version":"4.5.0"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2020-0152_abs_001_w2aab3b7c10b1b6b1aab1c15b1Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The prevalence, clinical characteristics and prognosis of pleural effusions (PEs) associated with ovarian cancer (OC) have seldom been addressed systematically, as in the current investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2020-0152_abs_002_w2aab3b7c10b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All records of consecutive women with a newly diagnosed OC in our institution over a 13-year period were retrospectively reviewed. Features of PEs on CT scans, pleural fluid analyses, need for definitive therapy of PEs, and the influence of PEs on the overall survival (OS) and progression-free survival (PFS) were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2020-0152_abs_003_w2aab3b7c10b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PEs were observed in 81 (43%) of 189 women with OC, either at presentation of cancer (55 patients) or during the course of the disease (26 patients). The causes of PEs were malignancy (55.5%), unknown (37%), or surgery-related (7.4%). The sensitivity of the cytologic diagnosis of malignant PEs was 79.1%. Sixty percent of malignant PEs required pleurodesis or indwelling pleural catheters for symptomatic relief. The presence of ascites strongly predicted PE development (odds ratio 43.2). Women with PEs fared much worse compared with those without PEs, in terms of OS (26.7 vs. 90.4\u00a0months), PFS (9.8 vs. 55.3\u00a0months) and tumor recurrences (86.4 vs. 43%). In multivariate analyses, PE remained as a relevant independent variable associated with poor outcome (hazard ratio 9.73 for OS, and 3.87 for PFS). Notably, PEs small enough to preclude tapping, and thus of unknown origin, had a similar bad prognosis as malignant PEs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2020-0152_abs_004_w2aab3b7c10b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OC patients with PEs experience decreased survival, including those with trace effusions not amenable to tapping.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2020-0152","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T20:31:37Z","timestamp":1616617897000},"page":"75-81","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence, clinical characteristics, and outcome of pleural effusions in ovarian cancer"],"prefix":"10.1515","volume":"6","author":[{"given":"Jos\u00e9 M.","family":"Porcel","sequence":"first","affiliation":[{"name":"Pleural Medicine Unit, Department of Internal Medicine , Hospital Universitari Arnau de Vilanova, IRBLleida, University of Lleida , Lleida , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology , Hospital Universitari Arnau de Vilanova, IRBLleida , Lleida , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Porcel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , Hospital Universitario Principe de Asturias , Alcal\u00e1 de Henares , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bielsa","sequence":"additional","affiliation":[{"name":"Pleural Medicine Unit, Department of Internal Medicine , Hospital Universitari Arnau de Vilanova, IRBLleida, University of Lleida , Lleida , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Pardina","sequence":"additional","affiliation":[{"name":"Department of Radiology , Hospital Universitari Arnau de Vilanova, IRBLleida , Lleida , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonieta","family":"Salud","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology , Hospital Universitari Arnau de Vilanova, IRBLleida , Lleida , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"2025120909232256821_j_pp-2020-0152_ref_001_w2aab3b7c10b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Torre, LA, Trabert, B, DeSantis, CE, Miller, KD, Samimi, G, Runowicz, CD, et al.. 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