{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:53:31Z","timestamp":1792086811983,"version":"4.4.0"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2021-0125_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a promising treatment for peritoneal cancer that entails, however, potential risks for the caregivers in the operating room (OR). This study aimed to reach a consensus within the PIPAC community on a comprehensive safety protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2021-0125_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Active PIPAC centers were invited to participate in a two-round Delphi process on 43 predefined items: concise summaries of the existing evidence were presented together with questions formulated using the population, intervention, comparator, and outcome framework. According to the Grading of Recommendations Assessment, Development, and Evaluation, the strength of recommendation was voted by panelists, accepting a consensus threshold of \u226550% of the agreement for any of the four grading options, or \u226570% in either direction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2021-0125_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-seven out of 66 invited panelists answered both rounds (response rate 76%). The consensus was reached for 41 out of 43 items (95.3%). Strong and weak recommendations were issued for 30 and 10 items, respectively. A positive consensual recommendation was issued to activate laminar airflow without specific strength, neither strong nor weak. No consensus was reached for systematic glove change for caregivers with a high risk of exposure and filtering facepiece mask class 3 for caregivers with low risk of exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2021-0125_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A high degree of consensus was reached for a comprehensive safety protocol for PIPAC, adapted to the risk of exposure for the different caregivers in the OR. This consensus can serve as a basis for education and help reach a high degree of adherence in daily practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2021-0125","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T06:55:32Z","timestamp":1635836132000},"page":"139-149","source":"Crossref","is-referenced-by-count":20,"title":["Consensus statement on safety measures for pressurized intraperitoneal aerosol chemotherapy"],"prefix":"10.1515","volume":"6","author":[{"given":"Arnaud","family":"Girardot-Miglierina","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery , Lausanne University Hospital CHUV, University of Lausanne (UNIL) , Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-3312","authenticated-orcid":false,"given":"Daniel","family":"Clerc","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery , Lausanne University Hospital CHUV, University of Lausanne (UNIL) , Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Alyami","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Oncology , Oncology Center, King Khalid Hospital , Najran , Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Villeneuve","sequence":"additional","affiliation":[{"name":"Department of Public Health , Clinical Research and Epidemiological Unit, Lyon University Hospital , Lyon , France"},{"name":"University of Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-3697","authenticated-orcid":false,"given":"Olivia","family":"Sgarbura","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology , Cancer Institute Montpellier (ICM) , Montpellier , France"},{"name":"University of Montpellier , Montpellier , France"},{"name":"IRCM, Institut de Recherche en Canc\u00e9rologie de Montpellier, INSERM U1194, Universit\u00e9 de Montpellier , Montpellier , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Andr\u00e9","family":"Reymond","sequence":"additional","affiliation":[{"name":"Department of General and Transplant Surgery , University Hospital T\u00fcbingen and National Center for Pleura and Peritoneum , T\u00fcbingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery , Lausanne University Hospital CHUV, University of Lausanne (UNIL) , Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"2025120909295128510_j_pp-2021-0125_ref_001","doi-asserted-by":"crossref","unstructured":"Alyami, M, H\u00fcbner, M, Grass, F, Bakrin, N, Villeneuve, L, Laplace, N, et al.. 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