{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:36:08Z","timestamp":1791974168098,"version":"4.4.0"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2022-0102_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Safe implementation and thorough evaluation of new treatments require prospective data monitoring and standardization of treatments. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a promising alternative for the treatment of patients with peritoneal disease with an increasing number of suggested drug regimens. The aim was to reach expert consensus on current PIPAC treatment protocols and to define the most important research topics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2022-0102_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The expert panel included the most active PIPAC centers, organizers of PIPAC courses and principal investigators of prospective studies on PIPAC. A comprehensive literature review served as base for a two-day hybrid consensus meeting which was accompanied by a modified three-round Delphi process. Consensus bar was set at 70% for combined (strong and weak) positive or negative votes according to GRADE. Research questions were prioritized from 0 to 10 (highest importance).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2022-0102_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-two out of 26 invited experts completed the entire consensus process. Consensus was reached for 10\/10 final questions. The combination of doxorubicin (2.1\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and cisplatin (10.5\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) was endorsed by 20\/22 experts (90.9%). 16\/22 (72.7%) supported oxaliplatin at 120 with potential reduction to 90\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (frail patients), and 77.2% suggested PIPAC-Ox in combination with 5-FU. Mitomycin-C and Nab-paclitaxel were favoured as alternative regimens. The most important research questions concerned PIPAC conditions (n=3), standard (n=4) and alternative regimens (n=5) and efficacy of PIPAC treatment (n=2); 8\/14 were given a priority of\u00a0\u22658\/10.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2022-0102_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The current consensus should help to limit heterogeneity of treatment protocols but underlines the utmost importance of further research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2022-0102","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T01:37:06Z","timestamp":1646185026000},"page":"1-7","source":"Crossref","is-referenced-by-count":55,"title":["Consensus statement for treatment protocols in pressurized intraperitoneal aerosol chemotherapy (PIPAC)"],"prefix":"10.1515","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-3697","authenticated-orcid":false,"given":"Olivia","family":"Sgarbura","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology , Cancer Institute of Montpellier, University of Montpellier , Montpellier , France"},{"name":"IRCM, Institut de Recherche en Canc\u00e9rologie de Montpellier, INSERM U1194 , Universit\u00e9 de Montpellier, Institut r\u00e9gional du Cancer de Montpellier , Montpellier , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisse","family":"Eveno","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncological Surgery , University of Lille, Claude Huriez University Hospital , Lille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Alyami","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Oncology , Oncology Center, King Khalid Hospital , Najran , Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoual","family":"Bakrin","sequence":"additional","affiliation":[{"name":"Department of General Surgery & Surgical Oncology , Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon , Pierre-B\u00e9nite , France"},{"name":"Lyon University 1, EA 3738 CICLY , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3834-2271","authenticated-orcid":false,"given":"Delia Cortes","family":"Guiral","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Oncology , Oncology Center, King Khalid Hospital , Najran , Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7692-4419","authenticated-orcid":false,"given":"Wim","family":"Ceelen","sequence":"additional","affiliation":[{"name":"Department of GI Surgery , Ghent University Hospital , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4236-6310","authenticated-orcid":false,"given":"Xavier","family":"Delgadillo","sequence":"additional","affiliation":[{"name":"Centre M\u00e9dico Chirurgical Volta , Unit\u00e9 Sp\u00e9cialis\u00e9e de Chirurgie , La Chaux-de-Fonds , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh","family":"Dellinger","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology , City of Hope National Medical Center , Duarte , CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3981-1145","authenticated-orcid":false,"given":"Andrea","family":"Di Giorgio","sequence":"additional","affiliation":[{"name":"Peritoneal and Retroperitoneal Surgical Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7951-4041","authenticated-orcid":false,"given":"Amaniel","family":"Kefleyesus","sequence":"additional","affiliation":[{"name":"Department of General Surgery & Surgical Oncology , Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon , Pierre-B\u00e9nite , France"},{"name":"Department of Visceral Surgery , Lausanne University Hospital CHUV, University of Lausanne (UNIL) , Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Khomiakov","sequence":"additional","affiliation":[{"name":"P.A. 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