{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T23:34:27Z","timestamp":1789256067616,"version":"build-2803163510"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2022-0110_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Peritoneal dissemination from intraabdominal cancers is associated with poor prognosis and rapid disease progression. Hyperthermic intraperitoneal chemotherapy (HIPEC) is an antineoplastic treatment, which has improved survival and recurrence-free survival, but little is known about the acquired chemotherapy concentrations in local tissues. The aim of this study was to assess concentrations of carboplatin during and after HIPEC treatment dynamically and simultaneously in various abdominal organ tissues by means of microdialysis in a novel porcine model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2022-0110_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eight pigs underwent imitation cytoreductive surgery followed by HIPEC (90\u00a0min) using a carboplatin dosage of 800\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Microdialysis catheters were placed for sampling of drug concentrations in various solid tissues: peritoneum, liver, bladder wall, mesentery and in different depths of one\u00a0mm and four\u00a0mm in the hepatoduodenal ligament and rectum. During and after HIPEC, dialysates and blood samples were collected over 8\u00a0h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2022-0110_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No statistically significant differences in mean AUC\n                      <jats:sub>0-last<\/jats:sub>\n                      (range: 2,657\u20135,176\u00a0min\u00b7\u00b5g\/mL), mean C\n                      <jats:sub>max<\/jats:sub>\n                      (range: 10.6\u201326.0\u00a0\u00b5g\/mL) and mean T\n                      <jats:sub>max<\/jats:sub>\n                      (range: 105\u2013206\u00a0min) were found between the compartments. In plasma there was a tendency towards lower measures. No difference between compartments was found for tissue penetration. At the last samples obtained (450\u00a0min) the mean carboplatin concentrations were 4.9\u20139.9\u00a0\u00b5g\/mL across the investigated solid tissues.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2022-0110_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Equal carboplatin distribution in abdominal organ tissues, detectable concentrations for at least 6\u00a0h after HIPEC completion, and a carboplatin penetration depth of minimum four\u00a0mm were found. The present study proposes a new HIPEC porcine model for future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2022-0110","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T06:58:00Z","timestamp":1654239480000},"page":"117-125","source":"Crossref","is-referenced-by-count":7,"title":["Abdominal tissue concentrations and penetration of carboplatin in a HIPEC procedure \u2012 assessment in a novel porcine model"],"prefix":"10.1515","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5164-5197","authenticated-orcid":false,"given":"Elisabeth K.","family":"Petersen","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery , Aarhus University Hospital , Aarhus , Denmark"},{"name":"Department of Clinical Medicine , Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Bue","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Aarhus University Hospital , Aarhus , Denmark"},{"name":"Department of Clinical Medicine , Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Harlev","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Aarhus University Hospital , Aarhus , Denmark"},{"name":"Department of Clinical Medicine , Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea R.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Aarhus University Hospital , Aarhus , Denmark"},{"name":"Department of Clinical Medicine , Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Schmedes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology , Lillebaelt Hospital , Vejle , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelle","family":"Hanberg","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Aarhus University Hospital , Aarhus , Denmark"},{"name":"Department of Clinical Medicine , Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone K.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics , Odense University Hospital and Department of Clinical Medicine, University of Southern Denmark , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiken","family":"Stilling","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Aarhus University Hospital , Aarhus , Denmark"},{"name":"Department of Clinical Medicine , Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"2025120909233459744_j_pp-2022-0110_ref_001","doi-asserted-by":"crossref","unstructured":"Al-Shammaa, HA, Li, Y, Yonemura, Y. 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