{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:54:38Z","timestamp":1769694878264,"version":"3.49.0"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2022-0202_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS\/HIPEC) has enabled better prognosis for patients with peritoneal surface malignancies. However, in older age groups, short -and long-term outcomes are still perceived as poor. We evaluated patients aged 70 and over and determine if age is a predictor of morbidity, mortality and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2022-0202_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort analysis was performed on CRS\/HIPEC patients and categorised by age. The primary outcome was overall survival. Secondary outcomes included morbidity, mortality, hospital and incentive care unit (ICU) stay and early postoperative intraperitoneal chemotherapy (EPIC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2022-0202_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1,129 patients were identified with 134 aged 70+ and 935 under 70. There was no difference in OS (p=0.175) or major morbidity (p=0.051). Advanced age was associated with higher mortality (4.48 vs. 1.11\u202f%, p=0.010), longer ICU stay (p&lt;0.001) and longer hospitalisation (p&lt;0.001). The older group was less likely to achieve complete cytoreduction (61.2 vs. 73\u202f%, p=0.004) and receive EPIC (23.9 vs. 32.7\u202f%, p=0.040).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2022-0202_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients undergoing CRS\/HIPEC, age of 70 and above does not impact OS or major morbidity but is associated with increased mortality. Age alone should not be a limiting factor in selecting CRS\/HIPEC patients. Careful multi-disciplinary approach is needed when considering those of advanced age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2022-0202","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T14:02:38Z","timestamp":1681221758000},"page":"83-90","source":"Crossref","is-referenced-by-count":2,"title":["Overall survival and morbidity are not associated with advanced age for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a single centre experience"],"prefix":"10.1515","volume":"8","author":[{"given":"Ernest","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Surgery , Peritonectomy and Liver Cancer Unit, St George Hospital , Kogarah , NSW , Australia"},{"name":"St George Hospital Clinical School , University of New South Wales , Kogarah , NSW , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Shamavonian","sequence":"additional","affiliation":[{"name":"Department of Surgery , Peritonectomy and Liver Cancer Unit, St George Hospital , Kogarah , NSW , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine","family":"Mui","sequence":"additional","affiliation":[{"name":"Department of Surgery , Peritonectomy and Liver Cancer Unit, St George Hospital , Kogarah , NSW , Australia"},{"name":"St George Hospital Clinical School , University of New South Wales , Kogarah , NSW , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Hayler","sequence":"additional","affiliation":[{"name":"Department of Surgery , Peritonectomy and Liver Cancer Unit, St George Hospital , Kogarah , NSW , Australia"},{"name":"St George Hospital Clinical School , University of New South Wales , Kogarah , NSW , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh","family":"Karpes","sequence":"additional","affiliation":[{"name":"Department of Surgery , Peritonectomy and Liver Cancer Unit, St George Hospital , Kogarah , NSW , Australia"},{"name":"St George Hospital Clinical School , University of New South Wales , Kogarah , NSW , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruwanthi","family":"Wijayawardana","sequence":"additional","affiliation":[{"name":"Department of Surgery , Peritonectomy and Liver Cancer Unit, St George Hospital , Kogarah , NSW , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8879-4276","authenticated-orcid":false,"given":"Shoma","family":"Barat","sequence":"additional","affiliation":[{"name":"Department of Surgery , Peritonectomy and Liver Cancer Unit, St George Hospital , Kogarah , NSW , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nima","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Department of Surgery , Peritonectomy and Liver Cancer Unit, St George Hospital , Kogarah , NSW , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Surgery , Peritonectomy and Liver Cancer Unit, St George Hospital , Kogarah , NSW , Australia"},{"name":"St George Hospital Clinical School , University of New South Wales , Kogarah , NSW , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"2025120909245931214_j_pp-2022-0202_ref_001","doi-asserted-by":"crossref","unstructured":"Jacquet, P, Sugarbaker, PH. 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