{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:26:12Z","timestamp":1778538372771,"version":"3.51.4"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2023-0048_abs_001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malignant pleural effusion (MPE) is a common and debilitating condition seen in advanced cancer disease, and life-expectancy is short. Symptoms include pain and severe shortness of breath. Current first-line treatment options include pleural drainage using catheters as well as\u00a0pleurodesis. However, these treatment modalities are often inefficient and patients need repeated procedures. Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) is a minimally invasive procedure, where antineoplastic agents are nebulized under pressure into the pleural space.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2023-0048_abs_002\">\n                    <jats:title>Content<\/jats:title>\n                    <jats:p>We present the preliminary safety, feasibility, and\u00a0response assessment data for PITAC based on a comprehensive literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2023-0048_abs_003\">\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Five retrospective studies reported data on 38 PITACs in 21 patients. Data were heterogeneous and incomplete on several important aspects such as procedure, safety, local effect and long-term outcomes. PITAC seems technically feasible with a low risk of complications and may provide some reduction in MPE in selected cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2023-0048_abs_004\">\n                    <jats:title>Outlook<\/jats:title>\n                    <jats:p>PITAC seems feasible, but prospective phase I and\u00a0II studies are needed to define safety, indications, and efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2023-0048","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T22:50:22Z","timestamp":1715813422000},"page":"47-53","source":"Crossref","is-referenced-by-count":6,"title":["Review on treatment of pleural metastasis and malignant pleural effusion with Pressurized IntraThoracic Aerosol Chemotherapy (PITAC)"],"prefix":"10.1515","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9615-8704","authenticated-orcid":false,"given":"Pernille Schj\u00f8dt","family":"Hansen","sequence":"first","affiliation":[{"name":"Odense PIPAC Center (OPC) and Odense Pancreas Center (OPAC) , Odense University Hospital , Odense , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5719-4916","authenticated-orcid":false,"given":"Martin","family":"Graversen","sequence":"additional","affiliation":[{"name":"Odense PIPAC Center (OPC) and Odense Pancreas Center (OPAC) , Odense University Hospital , Odense , Denmark"},{"name":"Department of Surgery, HPB and Upper GI Section , Odense University Hospital , Odense , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9466-2333","authenticated-orcid":false,"given":"S\u00f6nke","family":"Detlefsen","sequence":"additional","affiliation":[{"name":"Odense PIPAC Center (OPC) and Odense Pancreas Center (OPAC) , Odense University Hospital , Odense , Denmark"},{"name":"Institute of Clinical Research, Faculty of Health Sciences , University of Southern Denmark , Odense , Denmark"},{"name":"Department of Pathology , Odense University Hospital , Odense , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-5005","authenticated-orcid":false,"given":"Michael Bau","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Odense PIPAC Center (OPC) and Odense Pancreas Center (OPAC) , Odense University Hospital , Odense , Denmark"},{"name":"Institute of Clinical Research, Faculty of Health Sciences , University of Southern Denmark , Odense , Denmark"},{"name":"Department of Surgery, HPB and Upper GI Section , Odense University Hospital , Odense , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"2025120909242983660_j_pp-2023-0048_ref_001","doi-asserted-by":"crossref","unstructured":"Semaan, R, Feller-Kopman, D, Slatore, C, Sockrider, M. 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