{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T17:01:50Z","timestamp":1773594110068,"version":"3.50.1"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2024-0009_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cancer cells can activate coagulation and inhibit fibrinolysis. The aim was to investigate the association between the burden of peritoneal metastases from colorectal cancer (PM-CRC) and biomarkers reflecting thrombin generation and fibrinolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2024-0009_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cohort of 55 patients with PM-CRC scheduled for cytoreductive surgery. Patients were grouped by the peritoneal cancer index (PCI) assessed intraoperatively into limited PM-CRC (PCI\u226415) and extensive PM-CRC (PCI&gt;15). Blood samples were obtained before surgery. Thrombin generation was measured\n                      <jats:italic>in\u00a0vivo<\/jats:italic>\n                      by thrombin-antithrombin complex (TAT) and prothrombin fragment 1+2 (F1+2), and ex\u00a0vivo by the endogenous thrombin potential (ETP). Fibrinolysis was analyzed with fibrin clot lysis assay, fibrinogen, and D-dimer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2024-0009_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Non-significantly decreased thrombin generation by F1+2 (p=0.72), TAT (p=0.32), and ETP (p=0.19) were observed in patients with extensive PM-CRC (n=9) compared with limited PM-CRC (n=46). Non-significantly prolonged 50\u202f% clot lysis time were found in patients with extensive PM-CRC than in patients with limited PM-CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2024-0009_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Minor non-significant differences in thrombin generation and fibrinolysis were found between patients with extensive PM-CRC and limited PM-CRC. Thus, increased peritoneal metastatic burden from colorectal cancer does not seem to affect thrombin generation and fibrinolysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2024-0009","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T08:31:01Z","timestamp":1730795461000},"page":"149-154","source":"Crossref","is-referenced-by-count":0,"title":["Extent of peritoneal metastases from colorectal cancer is not associated with changes in thrombin generation or fibrinolysis"],"prefix":"10.1515","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3153-6265","authenticated-orcid":false,"given":"Mikkel","family":"Lundbech","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry , 11297 Aarhus University Hospital , Aarhus N , Denmark"},{"name":"Department of Clinical Medicine , Aarhus University , Aarhus , Denmark"},{"name":"Department of Orthopaedics , Randers Regional Hospital , Randers , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas Engel","family":"Krag","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine , Aarhus University , Aarhus , Denmark"},{"name":"Department of Plastic and Breast Surgery , Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene Hjerrild","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine , Aarhus University , Aarhus , Denmark"},{"name":"Department of Surgery , Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte","family":"Brandsborg","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine , Aarhus University , Aarhus , Denmark"},{"name":"Department of Anesthesiology and Intensive Care , Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Mette","family":"Hvas","sequence":"additional","affiliation":[{"name":"Faculty of Health , Aarhus University , Aarhus , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"2026031516391808157_j_pp-2024-0009_ref_001","doi-asserted-by":"crossref","unstructured":"Abdol Razak, NB, Jones, G, Bhandari, M, Berndt, M, Metharom, P. 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