{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:20:34Z","timestamp":1790022034945,"version":"4.0.1"},"reference-count":44,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Junior Research Grant of the Medical Faculty of the University of Leipzig"},{"name":"Scholarship of the Medical Faculty of the University of Leipzig"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2024-0012_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The prognosis of patients with peritoneal metastases (PM) is poor, and these patients have a brief overall survival. Most patients with advanced PM receive palliative therapy to maintain their quality of life. In our current study, we investigated whether patient-specific 3D-tissue slices from patients with PM subjected to pressurized intraperitoneal aerosol chemotherapy could be cultured\n                      <jats:italic>in\u00a0vitro<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2024-0012_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Biopsies from gastric cancer patients with PM were characterized for cytokeratin-positive tumor cells and the proliferation marker Ki-67. Biopsies from seven patients were cut to 350\u202f\u00b5M thick slices in a standardized manner, cultured with 10\u202f\u00b5M 5-fluorouracil, doxorubicin, cisplatin, oxaliplatin, or irinotecan for 96\u202fh, and then examined histopathologically and via immunohistochemistry for persistent cytokeratin and Ki-67 expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2024-0012_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In vitro<\/jats:italic>\n                      cultured slices revealed a similar morphology to un-cultured specimens, and Ki-67-positive tumor cell areas were present after 96\u202fh. The total amount of tumor cells per slice was determined by pan-cytokeratin staining. In the doxorubicin-treated slices, the cytokeratin-positive tumor cell fraction and proliferative (Ki-67pos) cells were decreased. Patient-specific 3D-tissue-slice cultures from peritoneal biopsies were cultured\n                      <jats:italic>in\u00a0vitro<\/jats:italic>\n                      for up to 4\u00a0days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2024-0012_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Potentially, these cultures are a reliable model to evaluate the chemosensitivity of patients with PM. Further investigation is needed to match the chemosensitivity with the clinical course of these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2024-0012","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T13:50:31Z","timestamp":1740405031000},"page":"1-9","source":"Crossref","is-referenced-by-count":1,"title":["Patient-specific 3D-tissue slices from peritoneal metastases\u00a0\u2013 An\n                    <i>in\u00a0vitro<\/i>\n                    model for individual susceptibility analysis"],"prefix":"10.1515","volume":"10","author":[{"given":"Christian","family":"Etzold","sequence":"first","affiliation":[{"name":"Department of Visceral, Transplant, Thoracic and Vascular Surgery , University Hospital of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orestis","family":"Lyros","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant, Thoracic and Vascular Surgery , University Hospital of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Mehdorn","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant, Thoracic and Vascular Surgery , University Hospital of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Nowotny","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant, Thoracic and Vascular Surgery , University Hospital of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Niebisch","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant, Thoracic and Vascular Surgery , University Hospital of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-9391","authenticated-orcid":false,"given":"Boris","family":"Jansen-Winkeln","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant, Thoracic and Vascular Surgery , University Hospital of Leipzig , Leipzig , Germany"},{"name":"Department of General, Visceral and Oncological Surgery , St. Georg Hospital Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Schierle","sequence":"additional","affiliation":[{"name":"Institute of Pathology , University Hospital of Leipzig , Leipzig , Germany"},{"name":"Institute of Pathology , SLK-Kliniken Heilbronn , Heilbronn , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Gockel","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant, Thoracic and Vascular Surgery , University Hospital of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0537-3979","authenticated-orcid":false,"given":"Ren\u00e9","family":"Thieme","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplant, Thoracic and Vascular Surgery , University Hospital of Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"2025120909294645572_j_pp-2024-0012_ref_001","doi-asserted-by":"crossref","unstructured":"Sung, H, Ferlay, J, Siegel, RL, Laversanne, M, Soerjomataram, I, Jemal, A, et al.. 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