{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:13:35Z","timestamp":1792512815110,"version":"4.5.0"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_pp-2025-0011_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>peritoneal surface malignancy in children is rare with a dismal prognosis. This bicentric study evaluated CRS with HIPEC in patients aged 2\u201325\u00a0years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_pp-2025-0011_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Clinicopathological and treatment-related factors were retrospectively analyzed from 21 patients undergoing CRS and HIPEC between 2009 and 2022. Endpoints were feasibility, chemotherapeutic compound, complications, and overall survival\u00a0(OS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_pp-2025-0011_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean age was 20.4 years. The mean peritoneal cancer index (PCI) was 12.8. Mean follow-up period was 6.8 years. Median overall survival time was 2.4. 5-year survival rate was 42.9\u202f%. 76.2\u202f% had primary and 23.8\u202f% recurrent disease. The most common primary tumor locations were colon (33.3\u202f%) and appendix (14.3\u202f%). Adenocarcinoma was the most common histological subtype (71.4\u202f%). Univariable Cox regression analysis showed significant impaired OS after previous chemotherapy (p=0.46) and incomplete cytoreduction CCR-2 (p=0.43). No perioperative mortalities occurred. The incidence of major complications was 24\u202f%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_pp-2025-0011_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Multimodal treatment can be considered in pediatric patients with peritoneal carcinomatosis. It presents a safe and feasible therapy with manageable complications and no perioperative mortality when performed by an experienced multidisciplinary team. Indication for CRS and HIPEC in children should be an individual decision by an interdisciplinary tumor board in the absence of better alternatives.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/pp-2025-0011","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T07:57:49Z","timestamp":1746431869000},"page":"99-109","source":"Crossref","is-referenced-by-count":1,"title":["Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for children and young adults: experience from two high volume centers"],"prefix":"10.1515","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1034-7917","authenticated-orcid":false,"given":"Maximilian","family":"Eckert","sequence":"first","affiliation":[{"name":"Faculty of Medicine , University of Regensburg , Regensburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gerken","sequence":"additional","affiliation":[{"name":"Tumor Center\u00a0\u2013\u00a0Center for Quality Management and Health Services Research , University of Regensburg , Regensburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens M.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Surgery , University Medical Center Regensburg , Regensburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Blaj","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery , Hospital Barmherzige Br\u00fcder , Regensburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"F\u00fcsi","sequence":"additional","affiliation":[{"name":"Department for Pediatric and Adolescent Surgery , Medical University of Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Bogovic","sequence":"additional","affiliation":[{"name":"Department of Surgery , University Medical Center Regensburg , Regensburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Schlitt","sequence":"additional","affiliation":[{"name":"Department of Surgery , University Medical Center Regensburg , Regensburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hornung","sequence":"additional","affiliation":[{"name":"Department of Surgery , University Medical Center Regensburg , Regensburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pompiliu","family":"Piso","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery , Hospital Barmherzige Br\u00fcder , Regensburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miklos","family":"Acs","sequence":"additional","affiliation":[{"name":"Department of Surgery , University Medical Center Regensburg , Regensburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"2025092318543927410_j_pp-2025-0011_ref_001","doi-asserted-by":"crossref","unstructured":"van Baal, J, van Noorden, CJF, Nieuwland, R, Van de Vijver, KK, Sturk, A, van Driel, WJ, et al.. 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