{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:36:02Z","timestamp":1791974162959,"version":"4.4.0"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_pp-2025-0013_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In 2020, the International Society for the Study of the Pleura and Peritoneum (ISSPP) launched a database monitoring real-world data on Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)-directed therapy in patients with peritoneal metastases (PM). This study covers data from the third annual report on the ISSPP PIPAC database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2025-0013_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Systematic analysis of all data reported to the ISSPP PIPAC database between June 15th, 2020, and November 1st, 2024. We hypothesize that ISSPP PIPAC data align with existing literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2025-0013_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventeen PIPAC centers reported 3224 PIPAC treatments in 1126 patients with PM (median number of treatments 2, range 1\u201333). The median peritoneal cancer index (PCI) at PIPAC 1 was 19 and remained unchanged during subsequent treatments. The number of patients with &gt;500\u202fmL ascites significantly decreased from the first three PIPAC treatments to PIPAC 4+ (p&lt;0.01). Major complications (Dindo\u2013Clavien\u00a0\u22653b) occurred in 0.7\u202f% of the treatments, while Common. Terminology Criteria for Adverse Events (CTCAE) grades\u00a0\u22653 were reported in 5.2\u202f%. Peritoneal regression grading score (PRGS) was performed in 2306 (72\u202f%) of the treatments. At PIPAC 1, 2, and 3, complete or major response (mean PRGS\u00a0\u22642) was achieved in 57\u202f%, 72\u202f%, and 75\u202f% of the patients, respectively. Median overall survival from PIPAC 1 was 12.5\u00a0months. Patients with complete\/major response (mean PRGS\u00a0\u22642) at PIPAC 1-3 had a longer overall survival compared to patients with minimal\/no response (mean PRGS &gt;2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_pp-2025-0013_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study from the ISSPP PIPAC database provides substantial real-world data demonstrating the feasibility, safety, and potential effect of PIPAC-directed therapy in patients with\u00a0PM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/pp-2025-0013","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T01:52:12Z","timestamp":1749520332000},"page":"119-128","source":"Crossref","is-referenced-by-count":6,"title":["Real-world data on Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)-directed therapy in patients with peritoneal metastases; Third annual report from the ISSPP PIPAC database"],"prefix":"10.1515","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4358-6796","authenticated-orcid":false,"given":"Magnus Skov","family":"J\u00f8rgensen","sequence":"first","affiliation":[{"name":"Odense PIPAC Center (OPC) and Odense Pancreas Center (OPAC) , 11286 Odense University Hospital , Odense , Denmark"},{"name":"Department of Surgery , Odense University Hospital , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9615-8704","authenticated-orcid":false,"given":"Pernille Schj\u00f8dt","family":"Hansen","sequence":"additional","affiliation":[{"name":"Odense PIPAC Center (OPC) and Odense Pancreas Center (OPAC) , 11286 Odense University Hospital , Odense , Denmark"},{"name":"Department of Surgery , Odense University Hospital , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2721-0967","authenticated-orcid":false,"given":"Claus W.","family":"Fristrup","sequence":"additional","affiliation":[{"name":"Odense PIPAC Center (OPC) and Odense Pancreas Center (OPAC) , 11286 Odense University Hospital , Odense , Denmark"},{"name":"Department of Surgery , Odense University Hospital , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"Lausanne University Hospital CHUV, University of Lausanne (UNIL) , Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"So","sequence":"additional","affiliation":[{"name":"Surgery, National University Hospital , Singapore , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0270-5090","authenticated-orcid":false,"given":"Anne-Cecile","family":"Ezanno","sequence":"additional","affiliation":[{"name":"Department of Surgery , H\u00f4pital d\u2019Instruction des arm\u00e9es Begin , Saint-Mande , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hewett","sequence":"additional","affiliation":[{"name":"Department of Surgery , The Queen Elizabeth Hospital , Woodville South , South Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Ruiz-Marin","sequence":"additional","affiliation":[{"name":"Department of Surgery , Reina Sofia University General Hospital , Murcia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0852-6002","authenticated-orcid":false,"given":"G\u00fcnther A.","family":"Rezniczek","sequence":"additional","affiliation":[{"name":"Obstetrics & Gynecology , Marien Hospital Herne, Klinikum der Ruhr-Universit\u00e4t Bochum , Herne , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcl","family":"D\u00fczg\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology , \u0130stanbul \u00dcmraniye Training and Research Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4793-0008","authenticated-orcid":false,"given":"Marc","family":"Pocard","sequence":"additional","affiliation":[{"name":"Department of Digestive, Hepatobiliary Surgery and Liver Transplantation , Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance publique-H\u00f4pitaux de Paris , Paris , France"},{"name":"Universit\u00e9 Paris Cit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Casella","sequence":"additional","affiliation":[{"name":"General and Upper GI Surgery , University of Verona , Verona , Veneto , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lay","sequence":"additional","affiliation":[{"name":"Department of Gynecology Surgical Area at the Institute\u00a0of\u00a0Oncology A. H. Roffo , University of Buenos Aires , Buenos Aires ,\u00a0 Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Aral","sequence":"additional","affiliation":[{"name":"General Surgery Department , Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o , Porto , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarkan","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Department of Surgery , Paracelsus Medical University , Salzburg , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Laminger","sequence":"additional","affiliation":[{"name":"Department of Surgery , Center for Peritoneal Carcinomatosis, Hanusch-Krankenhaus , Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Glehen","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Digestive et Oncologique , H\u00f4pital Lyon Sud, Hospices Civils de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire-Ang\u00e9line","family":"Goutard","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Digestive et Oncologique , H\u00f4pital Lyon Sud, Hospices Civils de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8713-7821","authenticated-orcid":false,"given":"Laurent","family":"Villeneuve","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Digestive et Oncologique , H\u00f4pital Lyon Sud, Hospices Civils de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Di Giorgio","sequence":"additional","affiliation":[{"name":"Surgical Unit of Peritoneum and Retroperitoneum , Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-5005","authenticated-orcid":false,"given":"Michael Bau","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Odense PIPAC Center (OPC) and Odense Pancreas Center (OPAC) , 11286 Odense University Hospital , Odense , Denmark"},{"name":"Department of Surgery , Odense University Hospital , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"2025092318543928758_j_pp-2025-0013_ref_001","doi-asserted-by":"crossref","unstructured":"Li, Z, Wong, LCK, Sultana, R, Lim, HJ, Tan, JW, Tan, QX, et al.. A systematic review on quality of life (QoL) of patients with peritoneal metastasis (PM) who underwent pressurized intraperitoneal aerosol chemotherapy (PIPAC). Pleur Perit 2022;7:39\u201349. https:\/\/doi.org\/10.1515\/pp-2021-0154.","DOI":"10.1515\/pp-2021-0154"},{"key":"2025092318543928758_j_pp-2025-0013_ref_002","doi-asserted-by":"crossref","unstructured":"Lambert, LA, Wiseman, J. Palliative management of peritoneal metastases. Ann Surg Oncol 2018;25:2165\u201371. https:\/\/doi.org\/10.1245\/s10434-018-6335-7.","DOI":"10.1245\/s10434-018-6335-7"},{"key":"2025092318543928758_j_pp-2025-0013_ref_003","doi-asserted-by":"crossref","unstructured":"Alyami, M, H\u00fcbner, M, Grass, F, Bakrin, N, Villeneuve, L, Laplace, N, et al.. Pressurised intraperitoneal aerosol chemotherapy: rationale, evidence, and potential indications. The Lancet Oncol 2019;20:e368\u2013e77. https:\/\/doi.org\/10.1016\/s1470-2045(19)30318-3.","DOI":"10.1016\/S1470-2045(19)30318-3"},{"key":"2025092318543928758_j_pp-2025-0013_ref_004","doi-asserted-by":"crossref","unstructured":"Solass, W, Kerb, R, M\u00fcrdter, T, Giger-Pabst, U, Strumberg, D, Tempfer, C, et al.. 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Cancers (Basel) 2023;15:1125. https:\/\/doi.org\/10.3390\/cancers15041125.","DOI":"10.3390\/cancers15041125"},{"key":"2025092318543928758_j_pp-2025-0013_ref_012","doi-asserted-by":"crossref","unstructured":"Ramalho-Vasconcelos, F, Gomes, R, Bou\u00e7a-Machado, R, Aral, M, Nogueiro, J, Bou\u00e7a-Machado, T, et al.. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in the treatment of gastric cancer: feasibility, efficacy and safety-a systematic review and meta-analysis. J\u00a0Clin Med 2024;13. https:\/\/doi.org\/10.3390\/jcm13113320.","DOI":"10.3390\/jcm13113320"},{"key":"2025092318543928758_j_pp-2025-0013_ref_013","doi-asserted-by":"crossref","unstructured":"Pavone, M, Jochum, F, Lecointre, L, Bizzarri, N, Taliento, C, Restaino, S, et al.. Efficacy and safety of pressurized intraperitoneal aerosol chemotherapy (PIPAC) in ovarian cancer: a systematic review of current evidence. Arch Gynecol Obstet 2024;310:1845\u201356. https:\/\/doi.org\/10.1007\/s00404-024-07586-z.","DOI":"10.1007\/s00404-024-07586-z"},{"key":"2025092318543928758_j_pp-2025-0013_ref_014","doi-asserted-by":"crossref","unstructured":"Casella, F, Bencivenga, M, Brancato, G, Torroni, L, Ridolfi, C, Puccio, C, et al.. Bidirectional approach with PIPAC and systemic chemotherapy for patients with synchronous gastric cancer peritoneal metastases (GCPM). Ann Surg Oncol 2023;30:5733\u201342. https:\/\/doi.org\/10.1245\/s10434-023-13572-7.","DOI":"10.1245\/s10434-023-13572-7"},{"key":"2025092318543928758_j_pp-2025-0013_ref_015","doi-asserted-by":"crossref","unstructured":"Graversen, M, Detlefsen, S, Ainsworth, AP, Fristrup, CW, Knudsen, AO, Pfeiffer, P, et al.. Treatment of peritoneal metastasis with pressurized intraperitoneal aerosol chemotherapy: results from the prospective PIPAC-OPC2 Study. 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Ann Surg Oncol 2022;29:2104\u201313. https:\/\/doi.org\/10.1245\/s10434-021-10983-2.","DOI":"10.1245\/s10434-021-10983-2"}],"container-title":["Pleura and Peritoneum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/pp-2025-0013\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/pp-2025-0013\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T18:55:11Z","timestamp":1758653711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/pp-2025-0013\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,7,23]]},"published-print":{"date-parts":[[2025,9,24]]}},"alternative-id":["10.1515\/pp-2025-0013"],"URL":"https:\/\/doi.org\/10.1515\/pp-2025-0013","relation":{},"ISSN":["2364-7671","2364-768X"],"issn-type":[{"value":"2364-7671","type":"print"},{"value":"2364-768X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]}}}