{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:53:39Z","timestamp":1782773619759,"version":"3.54.5"},"reference-count":82,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The exposure of methylmercury (MeHg) has become a public health concern because of its neurotoxic effect. Various neurological symptoms were detected in Minamata disease patients, who got intoxicated by MeHg, including paresthesia, ataxia, gait disturbance, sensory disturbances, tremors, visual, and hearing impairments, indicating that MeHg could pass the blood-brain barrier (BBB) and cause impairment of neurons and other brain cells. Previous studies have reported some expected mechanisms of MeHg-induced neurotoxicity including the neuroinflammation pathway. It was characterized by the up-regulation of numerous pro-inflammatory cytokines expression. Therefore, the use of anti-inflammatories such as <jats:italic>N<\/jats:italic>-acetyl-<jats:sc>l<\/jats:sc>-cysteine (NAC) may act as a preventive compound to protect the brain from MeHg harmful effects. This mini-review will explain detailed information on MeHg-induced pro-inflammatory cytokines activation as well as possible preventive strategies using anti-inflammation NAC to protect brain cells, particularly in <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> studies.<\/jats:p>","DOI":"10.1515\/reveh-2020-0026","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T10:02:38Z","timestamp":1595930558000},"page":"233-238","source":"Crossref","is-referenced-by-count":10,"title":["Methylmercury-induced pro-inflammatory cytokines activation and its preventive strategy using anti-inflammation N-acetyl-l-cysteine: a mini-review"],"prefix":"10.1515","volume":"35","author":[{"given":"Muflihatul","family":"Muniroh","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Diponegoro University, Semarang, Central Java, 50275, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref121","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-069X-2-8","article-title":"Low level methylmercury exposure affects neuropsychological function in adults","volume":"2","year":"2003","journal-title":"Environ Health"},{"key":"ref761","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00204-014-1425-1","article-title":"Role of autophagy in methylmercury-induced neurotoxicity in rat primary astrocytes","volume":"90","year":"2016","journal-title":"Arch Toxicol"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2131\/fts.2.239","article-title":"Methylmercury induces expression of Interleukin-1\u03b2 and Interleukin-19 in mice brains","volume":"2","year":"2015","journal-title":"Fundam Toxicol Sci"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00204-014-1425-1","article-title":"Role of autophagy in methylmercury-induced neurotoxicity in rat primary astrocytes","volume":"90","year":"2016","journal-title":"Arch Toxicol"},{"key":"ref41","year":"2017","journal-title":"Mercury and health"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.2131\/jts.37.1275","article-title":"Methylmercury induces CCl2 expression through activation of Nf-Kappab in human 1321n1 astrocytes","volume":"37","year":"2012","journal-title":"J Toxicol Sci"},{"key":"ref781","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1038\/sj.onc.1206953","article-title":"The MRP family of drug efflux pumps","volume":"22","year":"2003","journal-title":"Oncogene"},{"key":"ref411","year":"2019","journal-title":"Atsdr\u2019s substance priority list"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/ajim.20476","article-title":"Mechanisms of mercury disposition in the body","volume":"50","year":"2007","journal-title":"Am J Ind Med"},{"key":"ref621","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neulet.2009.06.004","article-title":"Il-6 Release from mouse glia caused by MeHg requires cytosolic phospholipase A2 activation","volume":"461","year":"2009","journal-title":"Neurosci Lett"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.2337\/db06-0029","article-title":"The role of phosphoinositide 3-Kinase\/Akt signaling in low-dose mercury-induced mouse pancreatic beta-cell dysfunction in vitro and in vivo","volume":"55","year":"2006","journal-title":"Diabetes"},{"key":"ref31","year":"1999","journal-title":"Toxicological profile for mercury"},{"key":"ref441","year":"1999","journal-title":"Toxicological profile for mercury"},{"key":"ref71","year":"1997","journal-title":"Mercury study report to congress"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neulet.2011.04.004","article-title":"Methylmercury-induced Il-6 release requires phospholipase C activities","volume":"496","year":"2011","journal-title":"Neurosci Lett"},{"key":"ref801","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.bbi.2012.07.003","article-title":"Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood-brain barrier: protection by the antioxidant N-Acetylcysteine","volume":"26","year":"2012","journal-title":"Brain Behav Immun"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2210-4-6","article-title":"15-Deoxy-Delta 12, 14-prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress","volume":"4","year":"2004","journal-title":"BMC Pharmacol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1289\/ehp.6587","article-title":"Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000","volume":"112","year":"2004","journal-title":"Environ Health Perspect"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.neuro.2006.01.010","article-title":"Glutathione modulation influences methyl mercury induced neurotoxicity in primary cell cultures of neurons and astrocytes","volume":"27","year":"2006","journal-title":"Neurotoxicology"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.lfs.2015.04.024","article-title":"Suppression of methylmercury-Induced Il-6 and Mcp-1 expressions by N-Acetylcysteine in U-87mg human astrocytoma cells","volume":"134","year":"2015","journal-title":"Life Sci"},{"key":"ref771","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1289\/ehp.02110s5689","article-title":"Transport of toxic metals by molecular mimicry","volume":"110","year":"2002","journal-title":"Environ Health Perspect"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1080\/15287394.2012.697840","article-title":"Glia and methylmercury neurotoxicity","volume":"75","year":"2012","journal-title":"J Toxicol Environ Health A"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1289\/ehp.98106267","article-title":"N-Acetylcysteine as an antidote in methylmercury poisoning","volume":"106","year":"1998","journal-title":"Environ Health Perspect"},{"key":"ref751","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1289\/ehp.98106267","article-title":"N-Acetylcysteine as an antidote in methylmercury poisoning","volume":"106","year":"1998","journal-title":"Environ Health Perspect"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1289\/ehp.02110s5689","article-title":"Transport of toxic metals by molecular mimicry","volume":"110","year":"2002","journal-title":"Environ Health Perspect"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.bbi.2012.07.003","article-title":"Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood-brain barrier: protection by the antioxidant N-Acetylcysteine","volume":"26","year":"2012","journal-title":"Brain Behav Immun"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neulet.2009.06.004","article-title":"Il-6 Release from mouse glia caused by MeHg requires cytosolic phospholipase A2 activation","volume":"461","year":"2009","journal-title":"Neurosci Lett"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2131\/jts.36.389","article-title":"Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury","volume":"36","year":"2011","journal-title":"J Toxicol Sci"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1080\/15287394.2012.697840","article-title":"Glia and methylmercury neurotoxicity","volume":"75","year":"2012","journal-title":"J Toxicol Environ Health A"},{"key":"ref11","volume-title":"Guidance for identifiying populations at risk from mercury exposure","year":"2008"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.lfs.2015.04.024","article-title":"Suppression of methylmercury-Induced Il-6 and Mcp-1 expressions by N-Acetylcysteine in U-87mg human astrocytoma cells","volume":"134","year":"2015","journal-title":"Life Sci"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1476-069X-6-30","article-title":"Mercury in human brain, blood, muscle and toenails in relation to exposure: an autopsy study","volume":"6","year":"2007","journal-title":"Environ Health"},{"key":"ref481","year":"1997","journal-title":"Mercury study report to congress"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jneuroim.2005.09.007","article-title":"Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-Prostaglandin","volume":"171","year":"2006","journal-title":"J2. J. Neuroimmunol"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40001-017-0287-4","article-title":"Suppression of methylmercury-induced Mip-2 expression by N-Acetyl-L-Cysteine in murine Raw264.7 macrophage cell line","volume":"22","year":"2017","journal-title":"Eur J Med Res"},{"key":"ref741","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1016\/j.bbagen.2013.04.016","article-title":"The chemistry and biological activities of N-Acetylcysteine","volume":"1830","year":"2013","journal-title":"BBA \u2013 Gen Subjects"},{"key":"ref561","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/toxsci\/kfr252","article-title":"The Chemokine CCl2 protects against methylmercury neurotoxicity","volume":"125","year":"2012","journal-title":"Toxicol Sci"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1124\/jpet.107.122812","article-title":"Accelerated urinary excretion of methylmercury following administration of its antidote N-Acetylcysteine requires Mrp2\/Abcc2, the apical multidrug resistance-associated protein","volume":"322","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"ref491","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1289\/ehp.6587","article-title":"Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000","volume":"112","year":"2004","journal-title":"Environ Health Perspect"},{"key":"ref721","doi-asserted-by":"crossref","first-page":"15441","DOI":"10.1074\/jbc.M311844200","article-title":"cAMP- induced astrocytic differentiation of C6 glioma cells is mediated by autocrine Interleukin-6","volume":"279","year":"2004","journal-title":"J Biol Chem"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.2131\/jts.37.1275","article-title":"Methylmercury induces CCl2 expression through activation of Nf-Kappab in human 1321n1 astrocytes","volume":"37","year":"2012","journal-title":"J Toxicol Sci"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2131\/fts.2.239","article-title":"Methylmercury induces expression of Interleukin-1\u03b2 and Interleukin-19 in mice brains","volume":"2","year":"2015","journal-title":"Fundam Toxicol Sci"},{"key":"ref651","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40001-017-0287-4","article-title":"Suppression of methylmercury-induced Mip-2 expression by N-Acetyl-L-Cysteine in murine Raw264.7 macrophage cell line","volume":"22","year":"2017","journal-title":"Eur J Med Res"},{"key":"ref661","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/jat.3411","article-title":"Activation of Interleukin-6 and -8 expressions by methylmercury in human U937 macrophages involves Rela and P50","volume":"37","year":"2017","journal-title":"J Appl Toxicol"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.taap.2011.05.001","article-title":"Oxidative stress in MeHg-induced neurotoxicity","volume":"256","year":"2011","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref671","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuro.2011.10.003","article-title":"Effects of methylmercury on the secretion of pro-inflammatory cytokines from primary microglial cells and astrocytes","volume":"33","year":"2012","journal-title":"Neurotoxicology"},{"key":"ref811","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jneuroim.2005.09.007","article-title":"Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-Prostaglandin","volume":"171","year":"2006","journal-title":"J2. J. Neuroimmunol"},{"key":"ref791","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.neuro.2006.01.010","article-title":"Glutathione modulation influences methyl mercury induced neurotoxicity in primary cell cultures of neurons and astrocytes","volume":"27","year":"2006","journal-title":"Neurotoxicology"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1038\/sj.onc.1206953","article-title":"The MRP family of drug efflux pumps","volume":"22","year":"2003","journal-title":"Oncogene"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"15441","DOI":"10.1074\/jbc.M311844200","article-title":"cAMP- induced astrocytic differentiation of C6 glioma cells is mediated by autocrine Interleukin-6","volume":"279","year":"2004","journal-title":"J Biol Chem"},{"key":"ref501","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1367\/1539-4409(2003)003<0018:NRCBSA>2.0.CO;2","article-title":"Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood","volume":"3","year":"2003","journal-title":"Ambul Pediatr"},{"key":"ref431","volume-title":"Environmental health criteria","year":"1976"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1289\/ehp.10383","article-title":"N-Acetylcysteine as a potential antidote and biomonitoring agent of methylmercury exposure","volume":"116","year":"2008","journal-title":"Environ Health Perspect"},{"key":"ref451","year":"2017","journal-title":"Mercury and health"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yrtph.2016.03.017","article-title":"The Tibetan medicine zuotai differs from HgCl2 and MeHg in producing liver injury in mice","volume":"78","year":"2016","journal-title":"Regul Toxicol Pharmacol"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s12640-020-00174-4","article-title":"Activation of Mip-2 and Mcp-5 expression in methylmercury-exposed mice and their suppression by N-Acetyl-L-Cysteine","volume":"37","year":"2020","journal-title":"Neurotox Res"},{"key":"ref711","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neulet.2007.01.076","article-title":"Methylmercury causes Glial Il-6 release","volume":"416","year":"2007","journal-title":"Neurosci Lett"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/jnr.22819","article-title":"N-Acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus","volume":"90","year":"2012","journal-title":"J Neurosci Res"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2131\/jts.36.389","article-title":"Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury","volume":"36","year":"2011","journal-title":"J Toxicol Sci"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1367\/1539-4409(2003)003<0018:NRCBSA>2.0.CO;2","article-title":"Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood","volume":"3","year":"2003","journal-title":"Ambul Pediatr"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neulet.2007.01.076","article-title":"Methylmercury causes Glial Il-6 release","volume":"416","year":"2007","journal-title":"Neurosci Lett"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1289\/ehp.10383","article-title":"N-Acetylcysteine as a potential antidote and biomonitoring agent of methylmercury exposure","volume":"116","year":"2008","journal-title":"Environ Health Perspect"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1016\/j.bbagen.2013.04.016","article-title":"The chemistry and biological activities of N-Acetylcysteine","volume":"1830","year":"2013","journal-title":"BBA \u2013 Gen Subjects"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.2337\/db06-0029","article-title":"The role of phosphoinositide 3-Kinase\/Akt signaling in low-dose mercury-induced mouse pancreatic beta-cell dysfunction in vitro and in vivo","volume":"55","year":"2006","journal-title":"Diabetes"},{"key":"ref701","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neulet.2011.04.004","article-title":"Methylmercury-induced Il-6 release requires phospholipase C activities","volume":"496","year":"2011","journal-title":"Neurosci Lett"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1124\/jpet.107.122812","article-title":"Accelerated urinary excretion of methylmercury following administration of its antidote N-Acetylcysteine requires Mrp2\/Abcc2, the apical multidrug resistance-associated protein","volume":"322","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuro.2011.10.003","article-title":"Effects of methylmercury on the secretion of pro-inflammatory cytokines from primary microglial cells and astrocytes","volume":"33","year":"2012","journal-title":"Neurotoxicology"},{"key":"ref421","volume-title":"Guidance for identifiying populations at risk from mercury exposure","year":"2008"},{"key":"ref01","year":"2019","journal-title":"Atsdr\u2019s substance priority list"},{"key":"ref731","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.molbrainres.2004.05.022","article-title":"Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury","volume":"128","year":"2004","journal-title":"Brain Res Mol Brain Res"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.molbrainres.2004.05.022","article-title":"Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury","volume":"128","year":"2004","journal-title":"Brain Res Mol Brain Res"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/jnr.22819","article-title":"N-Acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus","volume":"90","year":"2012","journal-title":"J Neurosci Res"},{"key":"ref631","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2210-4-6","article-title":"15-Deoxy-Delta 12, 14-prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress","volume":"4","year":"2004","journal-title":"BMC Pharmacol"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/toxsci\/kfr252","article-title":"The Chemokine CCl2 protects against methylmercury neurotoxicity","volume":"125","year":"2012","journal-title":"Toxicol Sci"},{"key":"ref21","volume-title":"Environmental health criteria","year":"1976"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/ajim.20476","article-title":"Mechanisms of mercury disposition in the body","volume":"50","year":"2007","journal-title":"Am J Ind Med"},{"key":"ref681","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s12640-020-00174-4","article-title":"Activation of Mip-2 and Mcp-5 expression in methylmercury-exposed mice and their suppression by N-Acetyl-L-Cysteine","volume":"37","year":"2020","journal-title":"Neurotox Res"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yrtph.2016.03.017","article-title":"The Tibetan medicine zuotai differs from HgCl2 and MeHg in producing liver injury in mice","volume":"78","year":"2016","journal-title":"Regul Toxicol Pharmacol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1476-069X-6-30","article-title":"Mercury in human brain, blood, muscle and toenails in relation to exposure: an autopsy study","volume":"6","year":"2007","journal-title":"Environ Health"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-069X-2-8","article-title":"Low level methylmercury exposure affects neuropsychological function in adults","volume":"2","year":"2003","journal-title":"Environ Health"},{"key":"ref641","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.taap.2011.05.001","article-title":"Oxidative stress in MeHg-induced neurotoxicity","volume":"256","year":"2011","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/jat.3411","article-title":"Activation of Interleukin-6 and -8 expressions by methylmercury in human U937 macrophages involves Rela and P50","volume":"37","year":"2017","journal-title":"J Appl Toxicol"}],"container-title":["Reviews on Environmental Health"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/reveh\/35\/3\/article-p233.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/reveh-2020-0026\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T03:45:27Z","timestamp":1619063127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/reveh-2020-0026\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":82,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1515\/reveh-2020-0026","relation":{},"ISSN":["2191-0308","0048-7554"],"issn-type":[{"value":"2191-0308","type":"electronic"},{"value":"0048-7554","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,25]]}}}