{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T18:00:09Z","timestamp":1771956009223,"version":"3.50.1"},"reference-count":206,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    With the rapid expansion of industrial scale, an increasing number of fine particulate matter (PM\n                    <jats:sub>2.5<\/jats:sub>\n                    ) has bringing health concerns. Although exposure to PM\n                    <jats:sub>2.5<\/jats:sub>\n                    has\u00a0been clearly associated with male reproductive toxicity, the exact mechanisms are still unclear. Recent studies demonstrated that exposure to PM\n                    <jats:sub>2.5<\/jats:sub>\n                    can disturb spermatogenesis through destroying the blood-testis barrier (BTB), consisting of different junction types, containing tight junctions (TJs), gap junctions (GJs), ectoplasmic specialization (ES) and desmosomes. The BTB is one of the tightest blood-tissue barriers among mammals, which isolating germ cells from hazardous substances and immune cell infiltration during spermatogenesis. Therefore, once the BTB is destroyed, hazardous substances and immune cells will enter seminiferous tubule and cause adversely reproductive effects. In addition, PM\n                    <jats:sub>2.5<\/jats:sub>\n                    also has shown to cause cells and tissues\u00a0injury via inducing autophagy, inflammation, sex hormones disorder, and oxidative stress. However, the exact mechanisms of the disruption of the BTB, induced by PM\n                    <jats:sub>2.5<\/jats:sub>\n                    , are still unclear. It is suggested that more research is required to identify the potential mechanisms. In this review, we aim to understand the adverse effects on the BTB after exposure to PM\n                    <jats:sub>2.5<\/jats:sub>\n                    and explore its potential mechanisms, which provides novel insight into accounting for PM\n                    <jats:sub>2.5<\/jats:sub>\n                    -induced BTB injury.\n                  <\/jats:p>","DOI":"10.1515\/reveh-2022-0204","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T19:21:32Z","timestamp":1677784892000},"page":"233-249","source":"Crossref","is-referenced-by-count":7,"title":["The effects of fine particulate matter on the blood-testis barrier and its potential mechanisms"],"prefix":"10.1515","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9145-9604","authenticated-orcid":false,"given":"Shaokai","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Public Health , Nantong University , Nantong , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianlian","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Public Health , Nantong University , Nantong , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianglin","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Public Health , Nantong University , Nantong , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"2026022417021689997_j_reveh-2022-0204_ref_001","doi-asserted-by":"crossref","unstructured":"Mukherjee, A, Agrawal, M. A global perspective of fine particulate matter pollution and its health effects. 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