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The main pathological process of osteoporosis is the dynamic imbalance between bone absorption and bone formation, which can be caused by various factors such as air pollution. Particulate matter (PM)\n                    <jats:sub>2.5<\/jats:sub>\n                    refers to the fine particles in the atmosphere, which are small in volume and large in specific surface area. These particles are prone to carrying toxic substances and have negative effects on several extrapulmonary organs, including bones. In this review, we present relevant data from studies, which show that PM\n                    <jats:sub>2.5<\/jats:sub>\n                    is associated with abnormal bone turnover and osteoporosis. PM\n                    <jats:sub>2.5<\/jats:sub>\n                    may cause or aggravate bone loss by stimulating an inflammatory response, inducing oxidative damage, reducing estrogen efficiency by competitive binding to estrogen receptors, or endocrine disorder mediated by binding with aromatic hydrocarbon receptors, and affecting the synthesis of vitamin D to reduce calcium absorption. The cellular and molecular mechanisms involved in these processes are also summarized in this review.\n                  <\/jats:p>","DOI":"10.1515\/reveh-2023-0024","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T17:40:27Z","timestamp":1690911627000},"page":"765-775","source":"Crossref","is-referenced-by-count":9,"title":["Impacts and mechanisms of PM\n                    <sub>2.5<\/sub>\n                    on bone"],"prefix":"10.1515","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6400-7629","authenticated-orcid":false,"given":"Yuqing","family":"Tian","sequence":"first","affiliation":[{"name":"School of Public Health , North China University of Science and Technology , Tangshan , Hebei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Public Health , North China University of Science and Technology , Tangshan , Hebei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Hou","sequence":"additional","affiliation":[{"name":"School of Public Health , North China University of Science and Technology , Tangshan , Hebei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faming","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Public Health , North China University of Science and Technology , Tangshan , Hebei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"2024112615253093685_j_reveh-2023-0024_ref_001","unstructured":"Organization WH. 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