{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T08:35:55Z","timestamp":1793522155838,"version":"4.5.0"},"reference-count":75,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bisphenol-A (BPA) is a synthetic organic compound considered an endocrine disruptor. Childhood exposure to BPA has been linked to impaired memory and learning, as well as Attention Deficit Hyperactivity Disorder. The aim of this study was to review the available literature on prenatal exposure to BPA and its relationship to the neurocognitive development of children aged 2\u20135 years. This systematic review (CRD42023494940 registration PROSPERO) was conducted between December 2023 and May 2024, following the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines. The Web of Science, Embase, and PubMed databases were used for the search, with no publication date limit. The following terms, with the respective Boolean operators, were searched: ((bisphenol A) OR (BPA)) AND ((pregnancy) OR (pregnant woman)). Twenty-one longitudinal studies were selected for this review. Most studies have demonstrated negative effects of prenatal BPA exposure on the neurocognitive development of children aged 2\u20135 years. These results differed between the sexes, with females having lower emotional control, reduced language dominance and problem solving, and males having lower psychomotor development and higher prosocial behavior, among other differences. Overall, BPA exposure during pregnancy has been associated with hyperactivity, aggression, anxiety, depression, inattention, and sleep problems. It is concluded that maternal exposure to BPA during pregnancy results in adverse health effects in children aged 2\u20135 years, with impairments in their neurocognitive development.<\/jats:p>","DOI":"10.1515\/reveh-2024-0161","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:55:41Z","timestamp":1754373341000},"page":"820-833","source":"Crossref","is-referenced-by-count":6,"title":["Prenatal exposure to bisphenol-A and neurocognitive changes in children aged 2 to 5 years: a systematic review"],"prefix":"10.1515","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8111-0568","authenticated-orcid":false,"given":"Isabella","family":"Vian Matias de Oliveira","sequence":"first","affiliation":[{"name":"Faculdade de Nutri\u00e7\u00e3o , Universidade Federal de Mato Grosso , Cuiab\u00e1 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-5232","authenticated-orcid":false,"given":"Fernanda","family":"Martins de Albuquerque","sequence":"additional","affiliation":[{"name":"28130 Programa de P\u00f3s-gradua\u00e7\u00e3o em Alimenta\u00e7\u00e3o, Nutri\u00e7\u00e3o e Sa\u00fade, Universidade do Estado do Rio de Janeiro , Rio de Janeiro , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4478-3505","authenticated-orcid":false,"given":"Amanda","family":"de Jesus Fernandes","sequence":"additional","affiliation":[{"name":"Faculdade de Nutri\u00e7\u00e3o , Universidade Federal de Mato Grosso , Cuiab\u00e1 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7748-9460","authenticated-orcid":false,"given":"Priscila","family":"Berti Zanella","sequence":"additional","affiliation":[{"name":"Faculdade de Nutri\u00e7\u00e3o , Universidade Federal de Mato Grosso , Cuiab\u00e1 , Brasil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Educa\u00e7\u00e3o F\u00edsica, Universidade Federal de Mato Grosso , Cuiab\u00e1 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6518-6534","authenticated-orcid":false,"given":"Mariane","family":"Alves Silva","sequence":"additional","affiliation":[{"name":"Faculdade de Nutri\u00e7\u00e3o , Universidade Federal de Mato Grosso , Cuiab\u00e1 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"2025121816180794875_j_reveh-2024-0161_ref_001","doi-asserted-by":"crossref","unstructured":"Campanale, C, Massarelli, C, Savino, I, Locaputo, V, Uricchio, VF. 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Molecular mechanisms of action of BPA. Dose Response 2015;13. https:\/\/doi.org\/10.1177\/1559325815610582.","DOI":"10.1177\/1559325815610582"},{"key":"2025121816180794875_j_reveh-2024-0161_ref_015","doi-asserted-by":"crossref","unstructured":"Boudalia, S, Oudir, M. Bisphenol-A: legislation in industrials countries and in Algeria. Res J Environ Toxicol 2016;10:189\u201392. https:\/\/doi.org\/10.3923\/rjet.2016.189.192.","DOI":"10.3923\/rjet.2016.189.192"},{"key":"2025121816180794875_j_reveh-2024-0161_ref_016","doi-asserted-by":"crossref","unstructured":"Banerjee, O, Singh, S, Saha, I, Pal, S, Banerjee, M, Kundu, S, et al.. Molecular dissection of cellular response of pancreatic islet cells to Bisphenol-A (BPA): a comprehensive review. 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Eur J Pediatr 2021;180:3111\u201327. https:\/\/doi.org\/10.1007\/s00431-021-04085-0.","DOI":"10.1007\/s00431-021-04085-0"},{"key":"2025121816180794875_j_reveh-2024-0161_ref_068","doi-asserted-by":"crossref","unstructured":"Patisaul, HB. Achieving CLARITY on bisphenol A, brain and behaviour. J Neuroendocrinol 2020;32. https:\/\/doi.org\/10.1111\/jne.12730.","DOI":"10.1111\/jne.12730"},{"key":"2025121816180794875_j_reveh-2024-0161_ref_069","doi-asserted-by":"crossref","unstructured":"Sharma, A, Couture, J. A review of the pathophysiology, etiology, and treatment of attention-deficit hyperactivity disorder (ADHD). Ann Pharmacother 2014;48:209\u201325. https:\/\/doi.org\/10.1177\/1060028013510699.","DOI":"10.1177\/1060028013510699"},{"key":"2025121816180794875_j_reveh-2024-0161_ref_070","doi-asserted-by":"crossref","unstructured":"Schug, TT, Blawas, AM, Gray, K, Heindel, JJ, Lawler, CP. Elucidating the links between endocrine disruptors and neurodevelopment. 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