{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:31:05Z","timestamp":1792729865416,"version":"4.5.0"},"reference-count":56,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inorganic arsenic (iAs) is a toxic environmental pollutant linked to serious health risks, prompting global regulatory efforts. This study identifies major health conditions associated with iAs exposure using text network analysis, and assesses health risk assessments through an umbrella review and dose\u2013response analysis. It synthesizes previous systematic reviews to offer a broader perspective on iAs-related health effects. An optimized text network analysis-based search strategy was applied across multiple databases to identify relevant systematic reviews. An umbrella review framework was employed to synthesize and reinterpret findings across systematic reviews. The methodological quality of included systematic reviews was assessed using the A MeaSurement Tool to Assess systematic Reviews 2 tool. Extracted data on study characteristics, exposure levels, and risk estimates were analyzed to evaluate the dose-response relationship between iAs exposure and health outcomes. From 922 systematic reviews, 36 were included and categorized into 10 health condition groups. For example, seven SRs found a significant dose-response relationship between iAs and bladder cancer, with one systematic review reporting relative risks of 2.70, 4.20, and 5.80 at 10, 50, and 150\u202f\u00b5g\/L, respectively. Individual study analysis further showed that each 10\u202f\u00b5g\/L increase in iAs raised bladder cancer risk by 3.11\u202f% (p=0.003). iAs exposure is associated with hypertension, diabetes, cardiovascular disease, and adverse fetal outcomes. Dose-dependent increases in bladder cancer, lung cancer, and hypertension risks were observed. These findings support more precise health risk assessments and regulatory strategies.<\/jats:p>","DOI":"10.1515\/reveh-2025-0124","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:56:17Z","timestamp":1784872577000},"page":"433-446","source":"Crossref","is-referenced-by-count":1,"title":["Health risk assessment of inorganic arsenic: an umbrella review"],"prefix":"10.1515","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6478-0902","authenticated-orcid":false,"given":"Subeen","family":"Leem","sequence":"first","affiliation":[{"name":"Konyang Medical data Research group-KYMERA, Konyang University Hospital , Daejeon , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6192-2610","authenticated-orcid":false,"given":"Jieun","family":"Shin","sequence":"additional","affiliation":[{"name":"Konyang Medical data Research group-KYMERA, Konyang University Hospital , Daejeon , South Korea"},{"name":"Department of Biomedical Informatics , Konyang University College of Medicine , Daejeon , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3542-9403","authenticated-orcid":false,"given":"Ji-Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Konyang Medical data Research group-KYMERA, Konyang University Hospital , Daejeon , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-3081","authenticated-orcid":false,"given":"Min-Kyoung","family":"Seo","sequence":"additional","affiliation":[{"name":"Ministry of Food and Drug Safety , Osong-eup , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8261-1644","authenticated-orcid":false,"given":"Seonggeun","family":"Zee","sequence":"additional","affiliation":[{"name":"Ministry of Food and Drug Safety , Osong-eup , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8854-4058","authenticated-orcid":false,"given":"Seulki","family":"Lee","sequence":"additional","affiliation":[{"name":"Ministry of Food and Drug Safety , Osong-eup , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1230-9307","authenticated-orcid":false,"given":"Jong-Yeup","family":"Kim","sequence":"additional","affiliation":[{"name":"Konyang Medical data Research group-KYMERA, Konyang University Hospital , Daejeon , South Korea"},{"name":"Department of Biomedical Informatics , Konyang University College of Medicine , Daejeon , South Korea"},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Konyang University College of Medicine , Daejeon , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-7244","authenticated-orcid":false,"given":"Ju Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nursing, Kyung Hee University College of Nursing Science , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4961-3361","authenticated-orcid":false,"given":"Taeho Greg","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine , New Haven , CT , United States"},{"name":"Department of Public Health Sciences, University of Connecticut School of Medicine , Farmington , CT , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4143-7383","authenticated-orcid":false,"given":"Sung Ryul","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics , Konyang University College of Medicine , Daejeon , South Korea"},{"name":"Evidence Based Research Center , Konyang University Hospital , Daejeon , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"2026083109133850050_j_reveh-2025-0124_ref_001","doi-asserted-by":"crossref","unstructured":"Oremland, RS, Stolz, JF. 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