{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:13:49Z","timestamp":1788171229789,"version":"build-2803163510"},"reference-count":95,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The gut microbiota plays a central role in maintaining gastrointestinal (GI) health through its metabolic, immune-modulating, and barrier-supporting functions. Diet is among the most influential modifiable determinants shaping microbial composition and activity, thereby influencing susceptibility to GI disorders, particularly irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). This review synthesizes current evidence on the interplay between dietary patterns, gut microbiota, and the pathogenesis and management of IBS and IBD. The Mediterranean diet and plant-based dietary patterns were consistently associated with enrichment of short-chain fatty acid (SCFA)-producing taxa, including\n                    <jats:italic>Faecalibacterium prausnitzii<\/jats:italic>\n                    ,\n                    <jats:italic>Roseburia<\/jats:italic>\n                    , and\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    species, alongside enhanced intestinal barrier integrity, reduced systemic inflammation, and improved clinical outcomes in both IBS and IBD. The Low FODMAP (fermentable oligo-, di-, monosaccharides, and polyols) diet provided effective symptom relief in IBS, although its impact on microbial composition was modest and inconsistent. In contrast, the Western diet, ultra-processed foods, and the ketogenic diet were linked to dysbiosis, depletion of beneficial taxa such as\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    , increased intestinal permeability, and pro-inflammatory cytokine profiles that contributed to IBS symptomatology and IBD pathogenesis. The gut\u2013brain axis emerged as a key mediator of bidirectional signaling between the microbiota and the central nervous system, with relevance to both gastrointestinal and psychological manifestations of IBS and IBD. In conclusion, dietary patterns substantially modulate gut microbial composition and gastrointestinal health, and the Mediterranean diet represents the most favorable pattern for both IBS and IBD. Integration of dietary counseling into clinical management, alongside long-term randomized controlled trials combining microbiome profiling with clinical endpoints, is recommended to advance personalized, microbiota-targeted nutritional strategies.\n                  <\/jats:p>","DOI":"10.1515\/reveh-2026-0041","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:56:31Z","timestamp":1784084191000},"page":"375-387","source":"Crossref","is-referenced-by-count":0,"title":["Dietary patterns, gut microbiota, and gastrointestinal disorders: mechanistic insights into irritable bowel syndrome and inflammatory bowel disease"],"prefix":"10.1515","volume":"41","author":[{"given":"Yasmen","family":"Khial","sequence":"first","affiliation":[{"name":"Department of Nutrition Sciences, College of Health Sciences , Qatar University , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalima","family":"Lathief","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences, College of Health Sciences , Qatar University , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama","family":"Aliwi","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences, College of Health Sciences , Qatar University , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahd","family":"Alqashouti","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences, College of Health Sciences , Qatar University , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hibaalrahman","family":"Mohamedahmed","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences, College of Health Sciences , Qatar University , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fida","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences, College of Health Sciences , Qatar University , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-0511","authenticated-orcid":false,"given":"Reema","family":"Tayyem","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences, College of Health Sciences , Qatar University , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"2026083109133845249_j_reveh-2026-0041_ref_001","doi-asserted-by":"crossref","unstructured":"Anwar, HAO, Iftikhar, A, Muzaffar, H, Almatroudi, AAO, Allemailem, KAO, Navaid, S, et al.. Biodiversity of gut microbiota: impact of various host and environmental factors. Biomed Res Int 2021;2021:5575245.","DOI":"10.1155\/2021\/5575245"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_002","unstructured":"Bull, MJ, Plummer, NT. Part 1: the human gut microbiome in health and disease. Integr Med (Encinitas) 2014;13:17\u201322."},{"key":"2026083109133845249_j_reveh-2026-0041_ref_003","doi-asserted-by":"crossref","unstructured":"Thursby, E, Juge, N. Introduction to the human gut microbiota. Biochem J 2017;474:1823\u201336.","DOI":"10.1042\/BCJ20160510"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_004","doi-asserted-by":"crossref","unstructured":"Arumugam, M, Raes, J, Pelletier, E, Le Paslier, D, Yamada, T, Mende, DR, et al.. Enterotypes of the human gut microbiome. Nature 2011;473:174\u201380.","DOI":"10.1038\/nature09944"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_005","doi-asserted-by":"crossref","unstructured":"Hooper, LV, Gordon, JI. Commensal host-bacterial relationships in the gut. Science 2001;292:1115\u20138.","DOI":"10.1126\/science.1058709"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_006","doi-asserted-by":"crossref","unstructured":"Emminger, A, Kahmann, E, Savage, DS. A novel class of antitumour agents. II. In vitro testing. Cancer Lett 1977;2:273\u20138.","DOI":"10.1016\/S0304-3835(77)80032-3"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_007","doi-asserted-by":"crossref","unstructured":"Gill, SR, Pop, M, Deboy, RT, Eckburg, PB, Turnbaugh, PJ, Samuel, BS, et al.. Metagenomic analysis of the human distal gut microbiome. Science 2006;312:1355\u20139.","DOI":"10.1126\/science.1124234"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_008","doi-asserted-by":"crossref","unstructured":"Ramadan, YN, Kamel, AM, Medhat, MA, Hetta, HF. MicroRNA signatures in the pathogenesis and therapy of inflammatory bowel disease. Clin Exp Med 2024;24:217. https:\/\/doi.org\/10.1007\/s10238-024-01476-z.","DOI":"10.1007\/s10238-024-01476-z"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_009","doi-asserted-by":"crossref","unstructured":"Ramos, GP, Papadakis, KA. Mechanisms of disease: inflammatory bowel diseases. Mayo Clin Proc 2019;94:155\u201365. https:\/\/doi.org\/10.1016\/j.mayocp.2018.09.013.","DOI":"10.1016\/j.mayocp.2018.09.013"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_010","doi-asserted-by":"crossref","unstructured":"Spiller, AL, Costa, BG, Yoshihara, RNY, Nogueira, EJZ, Castelhano, NS, Santos, A, et al.. Ultra-processed foods, gut microbiota, and inflammatory bowel disease: a critical review of emerging evidence. Nutrients 2025;17:2677. https:\/\/doi.org\/10.3390\/nu17162677.","DOI":"10.3390\/nu17162677"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_011","doi-asserted-by":"crossref","unstructured":"Dale, HF, Kolby, M, Valeur, J. 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The efficacy of dietary therapies in modulating inflammatory biomarkers, clinical remission and quality of life in patients with inflammatory bowel disease: a network meta-analysis of 15 interventions. Front Nutr 2025;12:1668590. https:\/\/doi.org\/10.3389\/fnut.2025.1668590.","DOI":"10.3389\/fnut.2025.1668590"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_017","doi-asserted-by":"crossref","unstructured":"Dekaboruah, E, Suryavanshi, MV, Chettri, D, Verma, AK. Human microbiome: an academic update on human body site specific\u00a0surveillance and its possible role. Arch Microbiol 2020;202:2147\u201367. https:\/\/doi.org\/10.1007\/s00203-020-01931-x.","DOI":"10.1007\/s00203-020-01931-x"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_018","doi-asserted-by":"crossref","unstructured":"Rinninella, E, Raoul, P, Cintoni, M, Franceschi, F, Miggiano, GAD, Gasbarrini, A, et al.. What is the healthy gut microbiota composition? 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Inflamm Bowel Dis 2021;27:1\u20139. https:\/\/doi.org\/10.1093\/ibd\/izaa097.","DOI":"10.1093\/ibd\/izaa097"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_036","doi-asserted-by":"crossref","unstructured":"Garicano Vilar, E, Lopez Oliva, S, Penades, BF, Sanchez Nino, GM, Terren Lora, A, Sanz Rojo, S, et al.. Mediterranean diet effect on the intestinal microbiota, symptoms, and markers in patients with functional gastrointestinal disorders. Microorganisms 2024;12. https:\/\/doi.org\/10.3390\/microorganisms12101969.","DOI":"10.3390\/microorganisms12101969"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_037","doi-asserted-by":"crossref","unstructured":"Roses, C, Cuevas-Sierra, A, Quintana, S, Riezu-Boj, JI, Martinez, JA, Milagro, FI, et al.. Gut microbiota bacterial species associated with Mediterranean diet-related food groups in a northern Spanish population. Nutrients 2021;13. https:\/\/doi.org\/10.3390\/nu13020636.","DOI":"10.3390\/nu13020636"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_038","doi-asserted-by":"crossref","unstructured":"Wang, DD, Nguyen, LH, Li, Y, Yan, Y, Ma, W, Rinott, E, et al.. The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk. Nat Med 2021;27:333\u201343. https:\/\/doi.org\/10.1038\/s41591-020-01223-3.","DOI":"10.1038\/s41591-020-01223-3"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_039","doi-asserted-by":"crossref","unstructured":"Hargreaves, SM, Rosenfeld, DL, Moreira, AVB, Zandonadi, RP. Plant-based and vegetarian diets: an overview and definition of these dietary patterns. Eur J Nutr 2023;62:1109\u201321. https:\/\/doi.org\/10.1007\/s00394-023-03086-z.","DOI":"10.1007\/s00394-023-03086-z"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_040","doi-asserted-by":"crossref","unstructured":"Storz, MA. What makes a plant-based diet? A review of current concepts and proposal for a standardized plant-based dietary intervention checklist. Eur J Clin Nutr 2022;76:789\u2013800. https:\/\/doi.org\/10.1038\/s41430-021-01023-z.","DOI":"10.1038\/s41430-021-01023-z"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_041","doi-asserted-by":"crossref","unstructured":"Jin, Z, Zhou, T, Ye, K, Jiang, W, Liu, Z, Luo, L, et al.. Healthy plant-based diet is associated with a reduced risk of inflammatory bowel disease: a large-scale prospective analysis. Mol Nutr Food Res 2025;69:e70151. https:\/\/doi.org\/10.1002\/mnfr.70151.","DOI":"10.1002\/mnfr.70151"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_042","doi-asserted-by":"crossref","unstructured":"Limketkai, BN, Hamideh, M, Shah, R, Sauk, JS, Jaffe, N. Dietary patterns and their association with symptoms activity in inflammatory bowel diseases. Inflamm Bowel Dis 2022;28:1627\u201336. https:\/\/doi.org\/10.1093\/ibd\/izab335.","DOI":"10.1093\/ibd\/izab335"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_043","doi-asserted-by":"crossref","unstructured":"Limketkai, BN, Godoy-Brewer, G, Shah, ND, Maas, L, White, J, Parian, AM, et al.. Prebiotics for induction and maintenance of remission in inflammatory bowel disease: systematic review and meta-analysis. Inflamm Bowel Dis 2025;31:1220\u201330. https:\/\/doi.org\/10.1093\/ibd\/izae115.","DOI":"10.1093\/ibd\/izae115"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_044","doi-asserted-by":"crossref","unstructured":"Manandhar, A, Sabir, G, Abdelhady, HA, Oumar Abakar, A, Gangavarapu, RR, Mahmud, SA, et al.. Probiotic potential in irritable bowel syndrome and inflammatory bowel disease: a comprehensive systematic review. Cureus 2024;16:e72089. https:\/\/doi.org\/10.7759\/cureus.72089.","DOI":"10.7759\/cureus.72089"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_045","doi-asserted-by":"crossref","unstructured":"Hagan, M, Hayee, BH, Rodriguez-Mateos, A. (Poly)phenols in inflammatory bowel disease and irritable bowel syndrome: a review. Molecules 2021;26. https:\/\/doi.org\/10.3390\/molecules26071843.","DOI":"10.3390\/molecules26071843"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_046","doi-asserted-by":"crossref","unstructured":"Shen, X, Tilves, C, Kim, H, Tanaka, T, Spira, AP, Chia, CW, et al.. Plant-based diets and the gut microbiome: findings from the Baltimore longitudinal study of aging. Am J Clin Nutr 2024;119:628\u201338. https:\/\/doi.org\/10.1016\/j.ajcnut.2024.01.006.","DOI":"10.1016\/j.ajcnut.2024.01.006"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_047","doi-asserted-by":"crossref","unstructured":"Kahleova, H, Rembert, E, Alwarith, J, Yonas, WN, Tura, A, Holubkov, R, et al.. Effects of a low-fat vegan diet on gut microbiota in overweight individuals and relationships with body weight, body composition, and insulin sensitivity. A randomized clinical trial. Nutrients 2020;12. https:\/\/doi.org\/10.3390\/nu12102917.","DOI":"10.3390\/nu12102917"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_048","doi-asserted-by":"crossref","unstructured":"Djekic, D, Shi, L, Brolin, H, Carlsson, F, Sarnqvist, C, Savolainen, O, et al.. Effects of a vegetarian diet on cardiometabolic risk factors, gut microbiota, and plasma metabolome in subjects with ischemic heart disease: a randomized, crossover study. J\u00a0Am Heart Assoc 2020;9:e016518. https:\/\/doi.org\/10.1161\/jaha.120.016518.","DOI":"10.1161\/JAHA.120.016518"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_049","doi-asserted-by":"crossref","unstructured":"Ahrens, AP, Culpepper, T, Saldivar, B, Anton, S, Stoll, S, Handberg, EM, et al.. A six-day, lifestyle-based immersion program mitigates cardiovascular risk factors and induces shifts in gut microbiota, specifically lachnospiraceae, ruminococcaceae, faecalibacterium prausnitzii: a pilot study. Nutrients 2021;13. https:\/\/doi.org\/10.3390\/nu13103459.","DOI":"10.3390\/nu13103459"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_050","doi-asserted-by":"crossref","unstructured":"Kohnert, E, Kreutz, C, Binder, N, Hannibal, L, Gorkiewicz, G, Muller, A, et al.. Changes in gut microbiota after a four-week intervention with vegan vs. meat-rich diets in healthy participants: a randomized controlled trial. Microorganisms 2021;9. https:\/\/doi.org\/10.3390\/microorganisms9040727.","DOI":"10.3390\/microorganisms9040727"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_051","doi-asserted-by":"crossref","unstructured":"Toribio-Mateas, MA, Bester, A, Klimenko, N. Impact of plant-based meat alternatives on the gut microbiota of consumers: a real-world study. 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Multivariate modelling of faecal bacterial profiles of patients with IBS predicts responsiveness to a diet low in FODMAPs. Gut 2018;67:872\u201381. https:\/\/doi.org\/10.1136\/gutjnl-2016-313128.","DOI":"10.1136\/gutjnl-2016-313128"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_058","doi-asserted-by":"crossref","unstructured":"Clemente-Su\u00e1rez, VJ, Beltr\u00e1n-Velasco, AI, Redondo-Fl\u00f3rez, L, Mart\u00edn-Rodr\u00edguez, A, Tornero-Aguilera, JF. Global impacts of Western diet and its effects on metabolism and health: a narrative review. Nutrients 2023;15. https:\/\/doi.org\/10.3390\/nu15122749.","DOI":"10.3390\/nu15122749"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_059","doi-asserted-by":"crossref","unstructured":"Severino, A, Tohumcu, E, Tamai, L, Dargenio, P, Porcari, S, Rondinella, D, et al.. The microbiome-driven impact of Western diet in the development of noncommunicable chronic disorders. 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Gut microbiota in patients with irritable bowel Syndrome-A systematic review. Gastroenterology 2019;157:97\u2013108. https:\/\/doi.org\/10.1053\/j.gastro.2019.03.049.","DOI":"10.1053\/j.gastro.2019.03.049"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_093","doi-asserted-by":"crossref","unstructured":"Masanetz, RK, Winkler, J, Winner, B, G\u00fcnther, C, S\u00fc\u00df, P. The gut-immune-brain axis: an important route for neuropsychiatric morbidity in inflammatory bowel disease. Int J Mol Sci 2022;23. https:\/\/doi.org\/10.3390\/ijms231911111.","DOI":"10.3390\/ijms231911111"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_094","doi-asserted-by":"crossref","unstructured":"De Palma, GBP. Gut microbiome and its role in the pathophysiology of irritable bowel syndrome. Acerca Acta Gastroenterol Latinoam 2021;51:378\u201384.","DOI":"10.52787\/DXFC9250"},{"key":"2026083109133845249_j_reveh-2026-0041_ref_095","doi-asserted-by":"crossref","unstructured":"Liu, RT, Walsh, RFL, Sheehan, AE. 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