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The pathogenic basis behind most neurodegenerative diseases is that the disruption of protein homeostasis (i.e. proteostasis) at any level will eventually lead to protein misfolding. Misfolded proteins often aggregate and accumulate to trigger neurotoxicity through cellular stress pathways and consequently cause neurodegenerative diseases. The manifestation of a disease is usually dependent on the specific brain region that the neurotoxicity affects. Neurodegenerative diseases are age-associated, and their incidence is expected to rise as humans continue to live longer and pursue a greater life expectancy. We presently review the sequelae of protein misfolding and aggregation, as well as the role of these phenomena in several neurodegenerative diseases including Alzheimer\u2019s disease, Huntington\u2019s disease, amyotrophic lateral sclerosis, Parkinson\u2019s disease, transmissible spongiform encephalopathies, and spinocerebellar ataxia. Strategies for treatment and therapy are also conferred with respect to impairing, inhibiting, or reversing protein misfolding.<\/jats:p>","DOI":"10.1515\/revneuro-2016-0035","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T04:20:42Z","timestamp":1549858842000},"page":"339-358","source":"Crossref","is-referenced-by-count":165,"title":["Protein misfolding and aggregation in neurodegenerative diseases: a review of pathogeneses, novel detection strategies, and potential therapeutics"],"prefix":"10.1515","volume":"30","author":[{"given":"Jason","family":"Gandhi","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics , Stony Brook University School of Medicine , 101 Nicolls Road, Health Sciences Center , Stony Brook, NY 11794-8434 , USA"},{"name":"Medical Student Research Institute , St. George\u2019s University School of Medicine , Grenada , West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C.","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Department of Pathology , Stony Brook University School of Medicine , 101 Nicolls Road, Health Sciences Center , Stony Brook, NY 11794-8434 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Afridi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics , Stony Brook University School of Medicine , 101 Nicolls Road, Health Sciences Center , Stony Brook, NY 11794-8434 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohrab","family":"Vatsia","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery , Lenox Hill Hospital , 130 East 77th Street , New York, NY 10075 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjan","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , Stony Brook Southampton Hospital , 240 Meeting House Lane , Southampton, NY 11968 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Romanov","sequence":"additional","affiliation":[{"name":"Department of Urology, Health Sciences Center T9-040 , Stony Brook University School of Medicine , 101 Nicolls Road , Stony Brook, NY 11794-8093 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian V.J.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience , St. George\u2019s University School of Medicine , Grenada , West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sardar Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics , Stony Brook University School of Medicine , 101 Nicolls Road, Health Sciences Center , Stony Brook, NY 11794-8434 , USA"},{"name":"Department of Urology, Health Sciences Center T9-040 , Stony Brook University School of Medicine , 101 Nicolls Road , Stony Brook, NY 11794-8093 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"2021021420290519193_j_revneuro-2016-0035_ref_001_w2aab3b7b2b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s, A. 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