{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:26:05Z","timestamp":1790079965564,"version":"4.0.1"},"reference-count":156,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several neurobiological factors are related to opiate-use disorder (OUD), and among them, neurotrophins have a relevant role. Brain-derived neurotrophic factor (BDNF) is a central neurotrophin involved in many neuronal processes, and it has been related to several psychiatric diseases and addictive disorders. BDNF can be measured in plasma and serum; its levels may reflect BDNF concentrations in the central nervous system (CNS) and, indirectly, CNS processes. Hence, peripheral BDNF could be a biomarker in clinical practice. This manuscript explores the findings about peripheral BDNF and OUD in humans. Opiates induce neurotoxicity in the CNS, which may be correlated with modifications in BDNF expression. Thus, basal levels of peripheral BDNF in OUD patients may be altered, which could be modified with abstinence. Also, opiates may modify epigenetic processes that may be associated with peripheral concentrations of BDNF, and in this line, withdrawal could reflect recovering processes in the CNS. Additionally, treatment modifies the peripheral concentrations of BDNF, but the clinical implications of those changes are yet not elucidated. No specific conclusion can be performed and more investigation in this area is necessary to elucidate the real potential of peripheral BDNF as a biomarker.<\/jats:p>","DOI":"10.1515\/revneuro-2016-0078","type":"journal-article","created":{"date-parts":[[2017,3,18]],"date-time":"2017-03-18T23:29:58Z","timestamp":1489879798000},"page":"499-508","source":"Crossref","is-referenced-by-count":21,"title":["Peripheral levels of BDNF and opiate-use disorder: literature review and update"],"prefix":"10.1515","volume":"28","author":[{"given":"Raul Felipe","family":"Palma-\u00c1lvarez","sequence":"first","affiliation":[{"name":"Addiction and Dual Diagnosis Unit, Vall d\u2019Hebron University Hospital, Vall d\u2019Hebron-Public Health Agency (ASPB), Passeig Vall d\u2019Hebron 119-129, E-08035 Barcelona, Spain"},{"name":"Psychiatry Service, Vall d\u2019Hebron University Hospital, E-08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ros-Cucurull","sequence":"additional","affiliation":[{"name":"Addiction and Dual Diagnosis Unit, Vall d\u2019Hebron University Hospital, Vall d\u2019Hebron-Public Health Agency (ASPB), Passeig Vall d\u2019Hebron 119-129, E-08035 Barcelona, Spain"},{"name":"Psychiatry Service, Vall d\u2019Hebron University Hospital, E-08035 Barcelona, Spain"},{"name":"Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Universidad Aut\u00f3noma de Barcelona, Campus de Bellaterra, E-08193 Cerda\u00f1ola del Vall\u00e9s, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher","family":"Amaro-Hosey","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, Vall d\u2019Hebron University Hospital, E-08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Rodriguez-Cintas","sequence":"additional","affiliation":[{"name":"Addiction and Dual Diagnosis Unit, Vall d\u2019Hebron University Hospital, Vall d\u2019Hebron-Public Health Agency (ASPB), Passeig Vall d\u2019Hebron 119-129, E-08035 Barcelona, Spain"},{"name":"Psychiatry Service, Vall d\u2019Hebron University Hospital, E-08035 Barcelona, Spain"},{"name":"Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Universidad Aut\u00f3noma de Barcelona, Campus de Bellaterra, E-08193 Cerda\u00f1ola del Vall\u00e9s, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Grau-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Addiction and Dual Diagnosis Unit, Vall d\u2019Hebron University Hospital, Vall d\u2019Hebron-Public Health Agency (ASPB), Passeig Vall d\u2019Hebron 119-129, E-08035 Barcelona, Spain"},{"name":"Psychiatry Service, Vall d\u2019Hebron University Hospital, E-08035 Barcelona, Spain"},{"name":"Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Universidad Aut\u00f3noma de Barcelona, Campus de Bellaterra, E-08193 Cerda\u00f1ola del Vall\u00e9s, Spain"},{"name":"Biomedical Network Research Centre on Mental Health (CIBERSAM), E-28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Corominas-Roso","sequence":"additional","affiliation":[{"name":"Psychiatry Service, Vall d\u2019Hebron University Hospital, E-08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"S\u00e1nchez-Mora","sequence":"additional","affiliation":[{"name":"Psychiatry Service, Vall d\u2019Hebron University Hospital, E-08035 Barcelona, Spain"},{"name":"Biomedical Network Research Centre on Mental Health (CIBERSAM), E-28029 Madrid, Spain"},{"name":"Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addictions, Vall d\u2019Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, E-08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Roncero","sequence":"additional","affiliation":[{"name":"Addiction and Dual Diagnosis Unit, Vall d\u2019Hebron University Hospital, Vall d\u2019Hebron-Public Health Agency (ASPB), Passeig Vall d\u2019Hebron 119-129, E-08035 Barcelona, Spain"},{"name":"Psychiatry Service, Vall d\u2019Hebron University Hospital, E-08035 Barcelona, Spain"},{"name":"Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Universidad Aut\u00f3noma de Barcelona, Campus de Bellaterra, E-08193 Cerda\u00f1ola del Vall\u00e9s, Spain"},{"name":"Biomedical Network Research Centre on Mental Health (CIBERSAM), E-28029 Madrid, 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