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Furthermore, recently, genome-wide association studies (GWAS) identified 10 novel risk genes: <jats:italic>ABCA7<\/jats:italic>, <jats:italic>APOE<\/jats:italic>, <jats:italic>BIN1<\/jats:italic>, <jats:italic>CD2AP<\/jats:italic>, <jats:italic>CD33<\/jats:italic>, <jats:italic>CLU<\/jats:italic>, <jats:italic>CR1<\/jats:italic>, <jats:italic>MS4A6A<\/jats:italic>, <jats:italic>MS4A4E<\/jats:italic>, and <jats:italic>PICALM<\/jats:italic>, which play an important role for LOAD. In this review, the therapeutic approaches of AD by epigenetic modifications have been discussed. Nowadays, HDAC inhibitors have clinically proven its activity for epigenetic modifications. Furthermore, we try to establish the relationship between HDAC inhibitors and above mentioned LOAD risk genes. Finally, we are hoping that this review may open new area of research for AD treatment.<\/jats:p>","DOI":"10.1515\/revneuro-2017-0049","type":"journal-article","created":{"date-parts":[[2018,2,4]],"date-time":"2018-02-04T11:09:08Z","timestamp":1517742548000},"page":"241-260","source":"Crossref","is-referenced-by-count":37,"title":["Recent studies on cellular and molecular mechanisms in Alzheimer\u2019s disease: focus on epigenetic factors and histone deacetylase"],"prefix":"10.1515","volume":"29","author":[{"given":"Harikesh","family":"Dubey","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Vallabhbhai Patel Chest Institute, Faculty of Medicine , University of Delhi , Delhi 110007 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vallabhbhai Patel Chest Institute, Faculty of Medicine , University of Delhi , Delhi 110007 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunabha","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vallabhbhai Patel Chest Institute, Faculty of Medicine , University of Delhi , Delhi 110007 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"2024080906403077185_j_revneuro-2017-0049_ref_001_w2aab3b7b5b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Alarcon, J.M., Malleret, G., Touzani, K., Vronskaya, S., Ishii S., Kandel, E.R., and Barco, A. 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