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This review proposes an innovative point of view to understand that mood disorders and dementia have a common etiology in a stressful environment. We propose that distress produces sensory deprivation, and this interferes with the connection between the brain and the environment in which the subject lives. The auditory system can serve as an example to understand this idea. In this sense, distress impairs the auditory system and induces hearing loss or presbycusis at an early age; this can increase the cognitive load in stressed people, which can stimulate the development of dementia in them. On the other hand, distress impairs the auditory system and increases the excitability of the amygdala, a limbic structure involved in the emotional processing of sounds. A consequence of these alterations could be the increase in the persistence of auditory fear memory, which could increase the development of mood disorders. Finally, it is important to emphasize that stress is an evolutionary issue that is necessary to understand the mental health of humans in these modern times. This article is a contribution to this discussion and will provide insights into the origin of stress-related neuropsychiatric disorders.<\/jats:p>","DOI":"10.1515\/revneuro-2018-0018","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T09:01:44Z","timestamp":1536224504000},"page":"317-324","source":"Crossref","is-referenced-by-count":16,"title":["Effects of stress on the auditory system: an approach to study a common origin for mood disorders and dementia"],"prefix":"10.1515","volume":"30","author":[{"given":"Catherine","family":"P\u00e9rez-Valenzuela","sequence":"first","affiliation":[{"name":"Laboratory of Stress Neurobiology , Institute of Physiology, Faculty of Sciences, Universidad de Valpara\u00edso, Gran Breta\u00f1a 1111 , Playa Ancha, Valpara\u00edso , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Terreros","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias de la Salud, Universidad de O\u2019Higgins , Rancagua , Chile"},{"name":"Auditory and Cognition Center (AUCO) , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexies","family":"Dagnino-Subiabre","sequence":"additional","affiliation":[{"name":"Laboratory of Stress Neurobiology , Institute of Physiology, Faculty of Sciences, Universidad de Valpara\u00edso, Gran Breta\u00f1a 1111 , Playa Ancha, Valpara\u00edso , Chile"},{"name":"Auditory and Cognition Center (AUCO) , Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"2023040103032568830_j_revneuro-2018-0018_ref_009_w2aab3b7b5b1b6b1ab1b4b1Aa","doi-asserted-by":"crossref","unstructured":"Baglietto-Vargas, D., Chen, Y., Suh, D., Ager R.R., Rodriguez-Ortiz, C.J., Medeiros, R., Myczek, K., Green, K.N., Baram, T.Z., and LaFerla, F.M. 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